The global market for protein kinase c beta (PKC-Beta) Inhibitors is increasing significantly. This increase in the market is majorly due to high efficacy of treatment for diabetes, cardiac disorder, cancer, and others has increased the scope for protein kinase c beta inhibitors. The advantage of long acting, specific and effective treatment of the diseases has increased the preference for protein kinase c beta inhibitors market.
The protein kinase c beta molecules are serine/threonine protein kinases, that perform a significant function in numerous cellular functions such as gene expression, hormone secretion, and cell growth and differentiation. The protein kinase - C (PKC) molecules are integrated into several important signal transduction pathways stimulated by a wide range of growth factors like GPCRs. These PKC enzyme are calcium and lipid sensitive. The phospholipase C enzymes hydrolyze phosphatidylinositol 4, 5-bisphosphate (PIP2) to produce membrane bound Di-acyl glycerol (DAG), which in turn activates inositol trisphosphate (IP3) and protein kinase c (PKC), which leads to mobilization of intracellular calcium. Protein kinase c (PKC) is expressed in most of the tissues and various protein kinase c (PKC) sub-families are expressed in the single cell.
The protein kinase c (PKC) beta inhibitors are available in two conventional isoforms, PKC-beta I and PKC-beta II with C1 domain. PKCβ1 (PRKCB) situated on chromosome 16p11.2. It comprises 17 exons. The PKCβ1 isoform is comparatively short amongst the two isoforms. It included two alternatively spliced mRNAs and it results from use of an alternating splice site at the 5'-end of the terminal exon. Both the PKCβ1 and PKCβ2 isoform has different C-terminus. It includes 671 amino acid proteins and is involved in B cell activation, endothelial cell proliferation, and endothelial cell proliferation. It also includes intestinal carbohydrate absorption, immediate stress. The protein kinase c PKCβ2/ PRKCB are situated on chromosome 16p11.2 which is composed of 17 exons, 673 amino acid proteins and with two alternatively spliced mRNAs. The PKCβ2 isoform is comparatively the longer isoform.
The Protein Kinase C Beta (PKC-Beta) Inhibitors market can be segmented into by therapy, by route of administration, by drug class and by geography. In the terms of therapy, the Protein Kinase C Beta (PKC-Beta) Inhibitors is classified into monotherapy and combination therapy. The combination therapy offers a wide therapeutic range, thus the segment is showing high acceptance. Several protein kinase C beta (PKC-Beta) inhibitors are still in drug pipeline. However, few drugs in phase 3 clinical trials has shown a promising results against the diabetes indication.
Based on specificity and selectivity of drug action, the protein kinase C beta (PKC-Beta) inhibitors are classified. According to drug class, protein kinase C beta (PKC-Beta) inhibitors can be classified as Phorbol esters, Indolocarbazole, Macrocyclic lactones, Nonsteroidal anti-oestrogen and others.
Based on the route of administration, several protein kinase C beta (PKC-Beta) inhibitors market is classified into intravenous, oral and others. Due to high safety, oral administration has been the preferred choice of option for the patient.
Geographically, North America occupies the largest market share followed by other developed region like Europe. United States have been the major market across the world. High and advanced drug research and development activities has boosted the North America market for protein kinase C beta (PKC-Beta) inhibitors. Moreover, Asia Pacific protein kinase C beta (PKC-Beta) inhibitors market is expected to have a significant growth due to factors such as rising population, and increasing disposable income. Due to these factors, the Asia Pacific market is observing high number of new entrants compared to those in developed regions.
The major players having presence in the global market include Boehringer Ingelheim, Eli Lilly., Novartis, Takeda Pharmaceutical Company Limited, Novartis AG, Keryx Biopharmaceuticals, Pfizer, Inc., Amgen Inc. amongst others.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.