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Vitreous Tamponades Market

Vitreous Tamponades Market (Product Type - Gaseous Tamponades and Liquid Tamponades (Silicone Oil and Perfluorocarbons); End User - Hospitals and Ophthalmology Clinics) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025

Global Vitreous Tamponades Market: Snapshot

A highly fragmented global vitreous tamponades market is distinctive in terms of dominance of a select number of players in each region. Keen players in the market have given thrust to research and development to introduce newer products to serve the demand for case-specific products for specialty medical procedures.

The global market for vitreous tamponades is primarily driven by the increasing incidence of retinal detachment, diabetic retinopathy, macular pucker, and other retinal disorders. As per statistics of the International Diabetes Federation, around 300 million diabetes cases were reported in 2010 globally and it is estimated to reach 438 million by 2030. The rising incidence of diabetes that is related to be a major cause of diabetic retinopathy and other retinal disorders is stoking the demand for tamponades to prevent impaired vision and even blindness.

Besides this, the growing geriatric population that is more susceptible to retinal breaks is also a key factor boosting the growth of vitreous tamponades market.

A report by Transparency Market Research (TMR) estimates the global vitreous tamponades market to attract a revenue of US$89.9 mn by the end of 2025 from US$69.3 mn in 2016 at a CAGR of 3.0% for the forecast period between 2017 and 2025.

global vitreous tamponades market

Gaseous Tamponades Gaining Traction due to Ease of Use, Low Cost

The report studies the global vitreous tamponades market on the basis of product type, end-user, and geography. Based on product type, the global vitreous tamponades market is divided into gaseous tamponades and liquid tamponades. Vis-à-vis revenue, of the two, liquid tamponades segment led the global vitreous tamponades market in 2016 accounting for 53.9% market share. The supremacy of the segment is due to the extensive use of liquid tamponades in European and Asian region for the treatment of retinal detachments, giant tears, proliferative diabetic retinopathy, and proliferative vitreoretinopathy. The segment of liquid tamponades has been further sub-segmented into silicone oil and perflurocarbon liquid. Of the two, silicone oil is anticipated to surpass in terms of growth rate during the 2017-2025 forecast period. On the other hand, the perflurocarbons liquid segment is likely to witness constant growth over the 2017-2025 forecast period as they are primarily used for the reattachment of giant retinal tears.

Gaseous tamponades, on the other hand, is expected to display the leading growth rate in the upcoming years. This is mainly because of low risk of emulsification, low cost, and ease of use. SF6, C2F8, and perfluropropane are the most common types of gaseous tamponades used in vitreoretinal surgeries worldwide. These gases offer advantages of being expansive that allows the retina and eyeball to gradually adjust to the occupying volume of the eye for better healing.

Based on end-user, the global vitreous tamponades market has been segmented into hospitals and ophthalmology clinics. Of the two, ophthalmology clinics held the leading share of the market in terms of revenue in 2016.

North America Leads Market due to High Incidence of Retinal Detachment

In terms of geography, the global vitreous tamponades market has been segmented into four major regions: North America, Asia Pacific, Europe, and Rest of the World. Powered by the U.S., North America held supremacy in terms of revenue over other key regions in the overall market in 2016. In the U.S., retinal detachment accounts as a major cause for morbidity with an incidence of 10.1 to 17.9 per 100,000 individuals.

Asia Pacific, on the other hand, is anticipated to emerge as a promising region and display increased market share over the forecast period from 2017 to 2025.

Leading players in the global vitreous tamponades market include Novartis AG, Valeant Pharmaceuticals, Dutch Ophthalmic Research Center B.V., AL. CHI. MI.A srl, Fluron GmbH, and Carl Zeiss Meditech AG.

Vitreous Tamponades Market to Gain Notable Revenues Owing to Increasing Demand from Developing Nations

The worldwide market for vitreous tamponades is fundamentally determined by the expanding frequency of retinal separation, diabetic retinopathy, macular pucker, and other retinal problems. The rising occurrence of diabetes that is identified with be a significant reason for diabetic retinopathy and other retinal problems is stirring up the interest for tamponades to forestall disabled vision and even visual deficiency. Other than this, the developing geriatric populace that is more vulnerable to retinal breaks is likewise a key factor boosting the development of vitreous tamponades market.

Based on categorization by end user, the global vitreous tamponades market is bifurcated into ophthalmology clinics, and hospitals. Among these, the market is dominated by the ophthalmology clinics segment on account of their rising popularity. Geographically, the market is dominated by North America with the United States generating the major revenue. Asia Pacific on the other side, the market is likely to witness lucrative growth opportunities in the coming years on account of the rising number of new entrants into the market.

The rising occurrence of retinal separation and other vitreoretinal messes that can be remedied with vitrectomy is decidedly affecting the vitreous tamponades market. Vitrectomy includes careful expulsion of the glassy humor to be supplanted with engineered substitutes known as glassy tamponades. In the natural eye, glassy humor is a crucial segment that goes about as nourishment and as a refractive medium. In case of injury or after maturing, the glassy humor breaks down prompting tearing or separation of the exceptionally delicate retina.

Additionally, developing old populace around the world is likewise considered as one of the key variables boosting the development of vitreous tamponades market. This is on the grounds that the matured populace has a high danger of retinal breaks that requires viable treatment.

Global vitreous tamponades market is segmented as follows:

by Product Type

  • Gaseous Tamponades
  • Liquid Tamponades
    • Silicone Oil
    • Perfluorocarbon Liquids

by End-user

  • Hospitals
  • Ophthalmology Clinics

by Geography

  • North America
    • US
    • Canada
  • Europe
    • UK
    • Germany
    • France
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Rest of Asia Pacific
  • Rest of the World

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Section 1 Preface 
1.1 Report Scope and Market Segmentation 
1.2 Research Highlights

Section 2 Assumptions and Research Methodology 
2.1 Assumptions
2.2 Research Methodology

Section 3 Executive Summary
3.1 Global Vitreous Tamponades Market Snapshot, 2016
3.2 Global Vitreous Tamponades Market: Opportunity Map

Section 4 Market Overview
4.1 Overview
4.2 Global Vitreous Tamponades Market Size (US$ Mn) Forecast, 2015–2025
4.3 Global Vitreous Tamponades Market Outlook
4.5 Global Vitreous Tamponades Market: Porter's Analysis
4.6 Global Vitreous Tamponades Market: Value Chain Analysis

Section 5 Market Dynamic
5.1 Drivers
      5.1.1 Rise in incidence of vitreoretinal disorders 
      5.1.2 Increase in geriatric population
      5.1.3 Rise in health care infrastructure
5.2 Restraints
      5.2.1 Complications associated with tamponades
      5.2.2 Price competitiveness
5.3 Opportunities
      5.3.1 Strong Research and Development Activities to Develop Novel Vitreous Tamponades
      5.3.2 Expansion in Emerging Geographies by Key Players
5.4 Key Trends 
      5.4.1 Investigational Novel Technologies & Products
      5.4.2 Use of Combinations as Intraocular Tamponades

Section 6 Global Vitreous Tamponades Market Analysis, by Product
6.1 Introduction
6.2 Global Vitreous Tamponades Market Value Share Analysis, by Product
6.3 Global Vitreous Tamponades Market Value and Volume Forecast By Product
      6.3.1 Gaseous Tamponades
      6.3.2 Liquid Tamponades
              6.3.2.1 Silicone Oil
              6.3.2.2 Perfluorocarbon Liquids (PFCL)
6.4 Global Vitreous Tamponades Market Attractiveness Analysis, by Product 

Section 7 Global Vitreous Tamponades Market Analysis, by End-user
7.1 Introduction
7.2 Global Vitreous Tamponades Market Value Share Analysis, by End-user
7.3 Global Vitreous Tamponades Market Analysis, by End-user 
      7.3.1 Hospitals
      7.3.2 Ophthalmology Clinics
7.4 Global Vitreous Tamponades Market Attractiveness Analysis, by End-user

Section 8 Global Vitreous Tamponades Market Analysis, by Region
8.1 Global Vitreous Tamponades Market Snapshot, by Country
8.2 Global Vitreous Tamponades Market Value Share Analysis, by Region
8.3 Global Vitreous Tamponades Market Forecast, by Region
8.4 Global Vitreous Tamponades Market Attractiveness Analysis, by Region
8.5 Global Vitreous Tamponades Market: Regional Trends

Section 9 North America Vitreous Tamponades Market Analysis
9.1 Key Findings
9.2 North America Vitreous Tamponades Market Overview
9.3 North America Market Value Share Analysis, by Product
9.4 North America Market Forecast, by Product
      9.4.1 Gaseous Tamponades
      9.4.2 Liquid Tamponades
              9.4.2.1 Silicone Oil
              9.4.2.2 Perfluorocarbon Liquids (PFCL)
9.5 North America Market Value Share Analysis, by End-user
9.6 North America Market Forecast, by End-user
      9.6.1 Hospitals
      9.6.2 Ophthalmology Clinics
9.7 Market Analysis, by Country
9.8 Market Value Share Analysis, by Country
9.9 Market Size (US$ Mn) Forecast, by Country/Sub-region, 2017–2025
      9.9.1 U.S.
      9.9.2 Canada
9.1 Market Attractiveness Analysis
      9.10.1 By Product
      9.10.2 By End-user
      9.10.3 By Country

Section 10 Europe Vitreous Tamponades Market Analysis
10.1 Key Findings
10.2 Europe Vitreous Tamponades Market Overview
10.3 Europe Market Value Share Analysis, by Product
10.4 Europe Market Forecast, by Product
      10.4.1 Gaseous Tamponades
      10.4.2 Liquid Tamponades
              10.4.2.1 Silicone Oil
              10.4.2.2 Perfluorocarbon Liquids (PFCL)
10.5 Europe Market Value Share Analysis, by End-user
10.6 Europe Market Forecast, by End-user
      10.6.1 Hospitals
      10.6.2 Ophthalmology Clinics
10.7 Market Analysis, by Country/Sub-region
10.8 Market Value Share Analysis, by Country/Sub-region
10.9 Market Size (US$ Mn) Forecast, by Country/Sub-region, 2017–2025
      10.9.1 Germany
      10.9.2 France      
      10.9.3 U.K.
      10.9.4 Rest of Europe
10.10 Market Attractiveness Analysis
      10.10.1 By Product
      10.10.2 By End-user
      10.10.3 By Country/Sub-region

Section 11 Asia Pacific Vitreous Tamponades Market Analysis
11.1 Key Findings
11.2 Asia Pacific Vitreous Tamponades Market Overview
11.3 Asia Pacific Market Value Share Analysis, by Product
11.4 Asia Pacific Market Forecast, by Product
      11.4.1 Gaseous Tamponades
      11.4.2 Liquid Tamponades
              11.4.2.1 Silicone Oil
              11.4.2.2 Perfluorocarbon Liquids (PFCL)
11.5 Asia Pacific Market Value Share Analysis, by End-user
11.6 Asia Pacific Market Forecast, by End-user
      11.6.1 Hospitals
      11.6.2 Ophthalmology Clinics
11.7 Market Analysis, by Country/Sub-region
11.8 Market Value Share Analysis, by Country/Sub-region
11.9 Market Size (US$ Mn) Forecast, by Country/Sub-region, 2017–2025
      11.9.1 Japan
      11.9.2 China
      11.9.3 India
      11.9.4 Rest of Asia Pacific
11.10 Market Attractiveness Analysis
      11.10.1 By Product
      11.10.2 By End-user
      11.10.3 By Country/Sub-region

Section 12 Rest of the World Vitreous Tamponades Market Analysis
12.1 Key Findings
12.2 Rest of the World Vitreous Tamponades Market Overview
12.3 Rest of the World Market Value Share Analysis, by Product
12.4 Rest of the World Market Forecast, by Product
      12.4.1 Gaseous Tamponades
      12.4.2 Liquid Tamponades
              12.4.2.1 Silicone Oil
              12.4.2.2 Perfluorocarbon Liquids (PFCL)
12.5 Rest of the World Market Value Share Analysis, by End-user
12.6 Rest of the World Market Forecast, by End-user
      12.6.1 Hospitals
      12.6.2 Ophthalmology Clinics
12.7 Market Attractiveness Analysis
      12.7.1 By Product
      12.7.2 By End-user

Section 13 Company Profiles
13.1 Global Vitreous Tamponades Market: Heat Map Analysis
13.2 Competition Matrix
13.3 Company Profiles
      13.3.1 Fluoron GmbH
              13.3.1.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.1.2. Product Portfolio
              13.3.1.3. SWOT Analysis
              13.3.1.4. Strategic Overview
      13.3.2 Carl Zeiss Meditec AG
              13.3.2.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.2.2. Financial Overview
              13.3.2.3. Product Portfolio
              13.3.2.4. SWOT Analysis
              13.3.2.5. Strategic Overview
      13.3.3 Dutch Ophthalmic Research Center (International) B.V. 
              13.3.3.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.3.2. Product Portfolio
              13.3.3.3. SWOT Analysis
              13.3.3.4. Strategic Overview
      13.3.4 AL.CHI.MI.A Srl 
              13.3.4.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.4.2. Product Portfolio
              13.3.4.3. SWOT Analysis
              13.3.4.4. Strategic Overview
      13.3.5 Arcadophta
              13.3.5.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.5.2. Product Portfolio
              13.3.5.3. SWOT Analysis
              13.3.5.4. Strategic Overview
      13.3.6 Valeant Pharmaceuticals International, Inc.
              13.3.6.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.6.2. Financial Overview
              13.3.6.3. Product Portfolio
              13.3.6.4. SWOT Analysis
              13.3.6.5. Strategic Overview
      13.3.7 Novartis AG
              13.3.7.1. Company Overview (HQ, Business Segments, Employee Strength)
              13.3.7.2. Financial Overview
              13.3.7.3. Product Portfolio
              13.3.7.4. SWOT Analysis
              13.3.7.5. Strategic Overview

List of Tables

Table 01: Global Vitreous Tamponades Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 02: Global Vitreous Tamponades Market Size (US$ Mn) Forecast, by Liquid Tamponades, 2015–2025
Table 03: Global Vitreous Tamponades Market Volume Forecast, by Product, 2015–2025 (No. of Units)
Table 04: Global Vitreous Tamponades Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 05: Global Vitreous Tamponades Market Size (US$ Mn) Forecast, by Region, 2015–2025
Table 06: North America Vitreous Tamponades Market Size (US$ Mn) Forecast, by Country, 2015–2025
Table 07: North America Vitreous Tamponades Market Size (US$ Mn) Forecast, by Product Type, 2015–2025
Table 08: North America Vitreous Tamponades Market Size (US$ Mn) Forecast, by Liquid Tamponades, 2015–2025
Table 09: North America Vitreous Tamponades Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 10: Europe Vitreous Tamponades Market Size (US$ Mn) Forecast, by Country/Sub-region, 2015–2025
Table 11: Europe Vitreous Tamponades Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 12: Europe Vitreous Tamponades Market Size (US$ Mn) Forecast, by Liquid Tamponades, 2015–2025
Table 13: Europe Vitreous Tamponades Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 14: Asia Pacific Vitreous Tamponades Market Size (US$ Mn) Forecast, by Country/Sub -region, 2015–2025
Table 15: Asia Pacific Vitreous Tamponades Market Size (US$ Mn) Forecast, by Product Type, 2015–2025
Table 16: Asia Pacific Vitreous Tamponades Market Size (US$ Mn) Forecast, by Liquid Tamponades, 2015–2025
Table 17: Asia Pacific Vitreous Tamponades Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 18: Rest of the World Vitreous Tamponades Market Size (US$ Mn) Forecast, by Product Type, 2015–2025
Table 19: Rest of the World Vitreous Tamponades Market Size (US$ Mn) Forecast, by Liquid Tamponades, 2015–2025
Table 20: Rest of the World Vitreous Tamponades Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 21: Business Segment: Fluoron GmbH 
Table 22: Business Segment: Carl Zeiss Meditec AG 
Table 23: Business Segment: Dutch Ophthalmic Research Center (International) B.V. 
Table 24: Business Segment: AL.CHI.MI.A Srl 
Table 25: Business Segment: Arcadophta
Table 26: Business Segment: Valeant Pharmaceuticals International, Inc.
Table 27: Business Segment: Novartis AG
List of Figures

Figure 01: Global Vitreous Tamponades Market Taxonomy
Figure 02: Global Vitreous Tamponades Market Size, by Product Type (US$ Mn), 2016
Figure 03: Global Vitreous Tamponades Market -Segments with Leading Market Share, 2016
Figure 04: Global Vitreous Tamponades Market Snapshot, By Region, 2016
Figure 05: Global Vitreous Tamponades Market -End-user Revenue (US$ Mn), 2016
Figure 06: Global Vitreous Tamponades Market -Product Type Revenue (US$ Mn), 2016
Figure 07: Global Vitreous Tamponades Market Size (US$ Mn) and Y-o-Y Growth (%) Projection, 2015–2025
Figure 08: Global Vitreous Tamponades Market Value Share, by Product type (2016)
Figure 09: Global Vitreous Tamponades Market Value Share, by End-user (2016)
Figure 10: Global Vitreous Tamponades Market Value Share, by Region (2016)
Figure 11: Global Vitreous Tamponades Market- Porter’s Analysis
Figure 12: Global Vitreous Tamponades Market- Value Chain Analysis
Figure 13: Global Vitreous Tamponades Market- Drivers and Restraints Snapshot Analysis
Figure 14: Global Vitreous Tamponades Market, Snapshot by Product
Figure 15: Global Vitreous Tamponades Market Value Share, by Product, 2017 and 2025
Figure 16: Global Liquid Tamponades Market Value Share, 2017 and 2025
Figure 17: Global Liquid Tamponades Market Attractiveness, 2017–2025
Figure 18: Global Vitreous Tamponades Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Gaseous Tamponades, 2015–2025
Figure 19: Global Vitreous Tamponades Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Liquid Tamponades, 2015–2025
Figure 20: Global Liquid Tamponades Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, Silicone Oil, 2015–2025
Figure 21: Global Liquid Tamponades Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, Perfluorocarbon Liquids, 2015–2025
Figure 22: Global Vitreous Tamponades Market Attractiveness, by Product, 2017–2025
Figure 23: Global Vitreous Tamponades Market, Snapshot by End-user
Figure 24: Global Vitreous Tamponades Market Value Share, by End-user, 2017 and 2025
Figure 25: Global Vitreous Tamponades Market Attractiveness Analysis, by End-user, 2017–2025
Figure 26: Global Vitreous Tamponades Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Hospitals, 2015–2025
Figure 27: Global Vitreous Tamponades Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Ophthalmology Clinics, 2015–2025
Figure 28: Global Vitreous Tamponades Market Snapshot, by Country 
Figure 29: Global Vitreous Tamponades Market Value Share, by Region, 2017 and 2025
Figure 30: Global Vitreous Tamponades Market Attractiveness Analysis, by Region, 2017–2025
Figure 31: Vitreous Tamponades Market: Regional Trends Snapshot
Figure 32: North America Vitreous Tamponades Market Size (US$ Mn) Forecast and Y-o-Y Growth Projection (%), 2015–2025
Figure 33: North America Vitreous Tamponades Market Value Share, by Country, 2017 and 2025
Figure 34: North America Vitreous Tamponades Market Attractiveness, by Country, 2017–2025
Figure 35: North America Vitreous Tamponades Market Value Share, by Product Type, 2017 and 2025
Figure 36: North America Vitreous Tamponades Market Attractiveness, by Product Type, 2017–2025
Figure 37: North America Liquid Tamponades Market Value Share, 2017 and 2025
Figure 38: North America Liquid Tamponades Market Attractiveness, 2017–2025
Figure 39: North America Vitreous Tamponades Market Value Share, by End-user, 2017 and 2025
Figure 40: North America Vitreous Tamponades Market Attractiveness Analysis, by End-user, 2017–2025
Figure 41: Europe Vitreous Tamponades Market Size (US$ Mn) Forecast and Y-o-Y Growth Projection (%), 2015–2025
Figure 42: Europe Vitreous Tamponades Market Value Share, by Country/Sub-region, 2017 and 2025
Figure 43: Europe Vitreous Tamponades Market Attractiveness, by Country/Sub-region, 2017–2025
Figure 44: Europe Vitreous Tamponades Market Value Share, by Product, 2017 and 2025
Figure 45: Europe Vitreous Tamponades Market Attractiveness, by Product, 2017–2025
Figure 46: Europe Liquid Tamponades Market Value Share, 2017 and 2025
Figure 47: Europe Liquid Tamponades Market Attractiveness, 2017–2025
Figure 48: Europe Vitreous Tamponades Market Value Share, by End-user, 2017 and 2025
Figure 49: Europe Vitreous Tamponades Market Attractiveness, by End-user, 2017–2025
Figure 50: Asia Pacific Vitreous Tamponades Market Size (US$ Mn) Forecast and Y-o-Y Growth Projection (%), 2015–2025
Figure 51: Asia Pacific Vitreous Tamponades Market Value Share, by Country/Sub -region, 2017 and 2025
Figure 52: Asia Pacific Vitreous Tamponades Market Attractiveness, by Country/Sub -region, 2017–2025
Figure 53: Asia Pacific Vitreous Tamponades Market Value Share, by Product Type, 2017 and 2025
Figure 54: Asia Pacific Vitreous Tamponades Market Attractiveness, by Product Type, 2017–2025
Figure 55: Asia Pacific Liquid Tamponades Market Value Share, 2017 and 2025
Figure 56: Asia Pacific Liquid Tamponades Market Attractiveness, 2017–2025
Figure 57: Asia Pacific Vitreous Tamponades Market Value Share, by End-user, 2017 and 2025
Figure 58: Asia Pacific Vitreous Tamponades Market Attractiveness Analysis, by End-user, 2017–2025
Figure 59: Rest of the World Vitreous Tamponades Market Size (US$ Mn) Forecast and Y-o-Y Growth Projection (%), 2015–2025
Figure 60: Rest of the World Vitreous Tamponades Market Value Share, by Product Type, 2017 and 2025
Figure 61: Rest of the World Vitreous Tamponades Market Attractiveness, by Product Type, 2017–2025
Figure 62: Rest of the World Liquid Tamponades Market Value Share, 2017 and 2025
Figure 63: Rest of the World Liquid Tamponades Market Attractiveness, 2017–2025
Figure 64: Rest of the World Vitreous Tamponades Market Value Share, by End-user, 2017 and 2025
Figure 65: Rest of the World Vitreous Tamponades Market Attractiveness Analysis, by End-user, 2017–2025
Figure 66: Heat Map Analysis for Vitreous Tamponades Market by Key Market Players
Figure 67: Vitreous Tamponades Market: Competition Matrix
Figure 68: Revenue (US$ Mn) and Y-o-Y Growth (%), 2013–2016 -Carl Zeiss Meditec AG 
Figure 69: Breakdown of Net Sales, by Region, 2016-Carl Zeiss Meditec AG 
Figure 70: Revenue (US$ Mn) and Y-o-Y Growth (%), 2013–2016 - Valeant Pharmaceuticals International Inc. 
Figure 71: Breakdown of Net Sales, by Business Segment, 2016 -Valeant Pharmaceuticals International Inc. 
Figure 72: Revenue (US$ Bn) and Y-o-Y Growth (%), 2014–2016 -Novartis AG 
Figure 73: Breakdown of Net Sales, by Business Segment, 2016 -Novartis AG 
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