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Thrombin Market

Thrombin Market (Product - Bovine Thrombin, Human Thrombin, and Recombinant Thrombin; Dosage Form - Powder Form and Solution Form; End User - Hospitals, Diagnostics Centers & Clinics, and Academics & Research Institutes) - Global Industry Analysis, Size, Share, Growth, Trends, & Forecast 2017 - 2025

Global Thrombin Market: Snapshot

Thrombin is serine protease blood plasma protein which converts fibrinogen into soluble fibrin to catalyze blood coagulation process. Globally commercially available therapeutic thrombin products are derived from bovine source, human plasma and genetic recombination (recombinant). Thrombin JMI, Evithrom, Recothrom, Thrombin Mochida, etc. are few approved hemostatic products in the USA and Japan. Thrombin is used in several medical surgeries in management of uncontrolled bleeding. Thrombin is also used in diagnostic centers and clinics in various applications such as clotting factor tests, coagulation assays, and defibrination of blood or plasma. R&D applications of thrombin includes in several research activities such as in vitro study, coagulation research, protein-structure analysis, medical research and biochemical research. Bovine thrombin is referred as thrombin fractionated from bovine blood. Thrombostat was the first bovine blood-based thrombin product approved by the U.S. FDA in 1943. Currently, there are few bovine thrombin brands available in market such as Thrombin JMI, Thrombi-Pad, and BioTrombina. Generally, bovine-based thrombin products have a black box warning due to the risk of abnormal hemostasis.

global thrombin market

Demand for Bovine Thrombin to Rise at Considerably High Pace

Among the key product types, the bovine thrombin segment recorded surging demand and emerged as a key revenue contributor to the global thrombin market in 2016. TMR expects the global thrombin market to set sail on a growth path in response to the rising availability of bovine-based hemostatic brands such as Thrombin JMI. Besides this, the market will benefit from the rising adoption of bovine-based products in various research and diagnostic applications. Experts have also observed a spike in the recombinant thrombin uptake, which is attributed to lesser post-operative complications and safer hemostatic se in comparison to human and bovine thrombin.

In terms of end user, the hospital segment held the dominant share of 56.2% in the global market in 2016. The rising hemostatic use of thrombin-based products during surgeries has fuelled the demand for thrombin in the hospitals segment. In addition, the market is likely to witness lucrative growth prospects in the diagnostic centers and clinics segment, which held a considerable share in the global market in 2016.

North America and Asia Pacific Emerge as Lucrative Markets for Thrombin

Geographically, thrombin market has been segmented into major four regions: North America, Europe, Asia Pacific, and Rest of World. In 2016, North America and Asia Pacific accounted for the largest share of the thrombin market followed by Europe. The United States held a significant share of the thrombin market in North America, accounting for 94.2% share in 2016. Japan dominated the market in Asia Pacific in 2016 due to adoption of new thrombin therapies led by high awareness, significant health care spending in overall national budgets, early availability of advanced technologies, and extensive research activities in these countries. However, Europe is growing steadily while Asia Pacific is anticipated to grow faster during the forecast period due to major contribution from countries like Japan, India and China.

The global thrombin market is fragmented in nature with a dispersed presence of few players in various countries. Market players with high revenue base such as Pfizer Inc., Johnson & Johnson Services Inc., and Mallinckrodt Pharmaceuticals dominate the global thrombin market. Shanghai RAAS blood products co., Ltd., Japan Blood Products Organization, and Mochida Pharmaceutical Co., Ltd. are few key players operating in Asia Pacific region.

Rising Number of Road Accidents and an Increase in the Blood Clotting Disorders to Bring Good Growth Opportunities for the Thrombin Market

The thrombin market is expected to gain good growth opportunities across the forecast period of 2017-2025 on the back of factors such as rising obesity levels and expanding cases of blood clotting disorders. The increasing number of road accidents will also play a major role in the increase in the incidence of trauma and surgery numbers. All these factors bode well for the growth of the thrombin market.

  • Thrombin is a serine protease blood plasma protein that converts fibrinogen into soluble fibrin for catalyzing the blood coagulation process. The growing awareness about the benefits of using thrombin in treating blood clotting disorders will bring promising growth for the thrombin market.
  • Beneficial government initiatives regarding quick hospitalization measures after accidents and an increase in the number of research collaborations will prove to be extensive growth factors that will have a profound impact on the thrombin market. Road accidents take place frequently in areas having remote access to transport and hence countries like India and China having more remote areas will boost the growth prospects of the thrombin market.
  • Research and development activities play a crucial role in the growth of the thrombin market. The players in the thrombin market indulge in these activities for discovering new formulations. These formulations are advantageous for increasing the revenues of the players in the thrombin market. Strategic collaborations are also crucial for increasing the growth rate of the thrombin market. The players are involved in these collaborations for expanding their footprint across the thrombin market.
  • The COVID-19 pandemic has not affected the thrombin market to a substantial extent. As medical services were permitted to function during the lockdown period, the thrombin market was not much impacted. However, minimal disturbances were observed which were cleared after the relaxations regarding lockdown were announced by many countries.

The global thrombin market is segmented as follows:

Product
  • Bovine Thrombin
  • Human Thrombin
  • Recombinant Thrombin

Dosage Form

 
  • Powder Form
  • Solution Form
  • Others

End User
  • Hospitals
  • Diagnostics Centers & Clinics
  • Academics and Research Institutes

Geography
  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • U.K.
    • France
    • Italy
    • Spain
    • Rest of the Europe
  • Asia Pacific
    • Japan
    • China
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Rest of World

    1. Preface
         1.1 Report Scope
         1.2 Market Segmentation 
         1.3 Research Highlights

    2. Assumptions and Research Methodology
         2.1 Assumptions
         2.2 Acronyms Used
         2.3 Research Methodology

    3. Executive Summary

    4. Market Overview
         4.1 Product Overview
         4.2 Key Industry Developments
         4.3 Global Thrombin Market Size (US$ Mn) Forecast
         4.4 Market Opportunity Map
         4.5 Market Indicators
         4.6 Porter’s Analysis 
         4.7 Global Thrombin Market Outlook

    5. Market Dynamics
         5.1 Drivers and Restraints Snapshot Analysis
         5.2 Drivers
         5.3 Restraints
         5.4 Opportunities
         5.5 Features of Ideal Hemostat at a glance
         5.6 Key Brand Analysis
         5.7 Regulatory Scenario 

    6. Global Thrombin Market Analysis, by Product
         6.1 Key Findings
         6.2 Introduction
         6.3 Global Thrombin Market Value Share Analysis, by Product
         6.4 Global Thrombin Market Forecast, by Product
               6.4.1. Bovine Thrombin
               6.4.2. Human Thrombin
               6.4.3. Recombinant Thrombin
         6.5 Global Thrombin Market Analysis, by Product 
         6.6 Global Thrombin Market Attractiveness Analysis, by Product

    7. Global Thrombin Market Analysis, by Dosage Form
         7.1 Key Findings
         7.2 Introduction
         7.3 Global Thrombin Market Value Share Analysis, by Dosage Form
         7.4 Global Thrombin Market Forecast, by Dosage Form
               7.4.1. Powder Forms
               7.4.2. Solution Forms
               7.4.3. Others
         7.5 Global Thrombin Market Analysis, by Dosage Form
         7.6 Global Thrombin Market Attractiveness Analysis, by Dosage Form

    8. Global Thrombin Market Analysis, by End-user
         8.1 Key Findings
         8.2 Introduction
         8.3 Global Thrombin Market Value Share Analysis, by End-user
         8.4 Global Thrombin Market Forecast, by End-user
               8.4.1. Hospitals
               8.4.2. Diagnostics Centers & Clinics
               8.4.3. Academics and Research Institutes
         8.5 Global Thrombin Market Analysis, by End-user
         8.6 Global Thrombin Market Attractiveness Analysis, by End-user

    9. Thrombin Market Analysis, by Region
         9.1 Global Thrombin Market Scenario
         9.2 Introduction
         9.3 Global Thrombin Market Value Share Analysis, by Region
               9.3.1 North America
               9.3.2 Europe
               9.3.3 Asia Pacific
               9.3.4 Rest of the World  
         9.4 Global Thrombin Market Forecast, by Region
         9.5 Global Thrombin Market Attractiveness Analysis, by Region

    10. North America Thrombin Market Analysis
         10.1 Key Findings
         10.2 North America Thrombin Market Overview
         10.3 North America Thrombin Market Value Share Analysis, by Country
         10.4 North America Thrombin Market Forecast, by Country
               10.4.1. U.S.
               10.4.2. Canada
         10.5 North America Thrombin Market Value Share Analysis, by Product
         10.6 North America Thrombin Market Forecast, by Product
         10.7 North America Thrombin Market Value Share Analysis, by Dosage Form
         10.8 North America Thrombin Market Forecast, by Dosage Form
         10.9 North America Thrombin Market Value Share Analysis, by End-user
         10.10 North America Thrombin Market Forecast, by End-user
         10.11 North America Thrombin Market Attractiveness Analysis

    11. Europe Thrombin Market Analysis
         11.1 Key Findings
         11.2 Europe Thrombin Market Overview
         11.3 Europe Thrombin Market Value Share Analysis, by Country
         11.4 Europe Thrombin Market Forecast, by Country
               11.4.1 Germany 
               11.4.2 U.K.
               11.4.3 France
               11.4.4 Italy
               11.4.5 Spain
               11.4.6 Rest of the Europe
         11.5 Europe Thrombin Market Value Share Analysis, by Product
         11.6 Europe Thrombin Market Forecast, by Product
         11.7 Europe Thrombin Market Value Share Analysis, by Dosage Form
         11.8 Europe Thrombin Market Forecast, by Dosage Form
         11.9 Europe Thrombin Market Value Share Analysis, by End-user
         11.10 Europe Thrombin Market Forecast, by End-user
         11.11 Europe Thrombin Market Attractiveness Analysis

    12. Asia Pacific Thrombin Market Analysis
         12.1 Key Findings
         12.2 Asia Pacific Thrombin Market Overview
         12.3 Asia Pacific Thrombin Market Value Share Analysis, by Country
         12.4 Asia Pacific Thrombin Market Forecast, by Country
               12.4.1 Japan
               12.4.2 China 
               12.4.3 Australia & New Zealand
               12.4.4 Rest of Asia Pacific
         12.5 Asia Pacific Thrombin Market Value Share Analysis, by Product
         12.6 Asia Pacific Thrombin Market Forecast, by Product
         12.7 Asia Pacific Thrombin Market Value Share Analysis, by Dosage Form
         12.8 Asia Pacific Thrombin Market Forecast, by Dosage Form
         12.9 Asia Pacific Thrombin Market Value Share Analysis, by End-user
         12.10 Asia Pacific Thrombin Market Forecast, by End-user
         12.11 Asia Pacific Thrombin Market Attractiveness Analysis

    13. Rest of the World Thrombin Market Analysis
         13.1 Key Findings
         13.2 Rest of the World Thrombin Market Overview
         13.3 Rest of the World Thrombin Market Value Share Analysis, by Country
         13.5 Rest of the World Thrombin Market Value Share Analysis, by Product
         13.6 Rest of the World Thrombin Market Forecast, by Product
         13.7 Rest of the World Thrombin Market Value Share Analysis, by Dosage Form
         13.8 Rest of the World Thrombin Market Forecast, by Dosage Form
         13.9 Rest of the World Thrombin Market Value Share Analysis, by End-user
         13.10 Rest of the World Thrombin Market Forecast, by End-user
         13.11 Rest of the World Thrombin Market Attractiveness Analysis

    14. Competition Landscape
         14.1 Competition Matrix 
         14.2 Thrombin Market: Heat Map Analysis by Company
         14.3 Company Profiles
               14.3.1 Johnson & Johnson Services, Inc.
                        14.3.1.1Company Details
                        14.3.1.1 Business Overview
                        14.3.1.2 Financial Overview
                        14.3.1.3 Strategic Overview
                        14.3.1.4 SWOT Analysis
               14.3.2 Pfizer, Inc.
                        14.3.2.1 Company Details
                        14.3.2.2 Business Overview
                        14.3.2.3 Financial Overview
                        14.3.2.4 Strategic Overview
                        14.3.2.5 SWOT Analysis
               14.3.3  Mallinckrodt Pharmaceuticals
                        14.3.3.1 Company Details
                        14.3.3.2 Business Overview
                        14.3.3.3 Financial Overview
                        14.3.3.4 Strategic Overview
                        14.3.3.5 SWOT Analysis
               14.3.4 Shanghai RAAS blood products co., Ltd.
                        14.3.4.1 Company Details
                        14.3.4.2 Business Overview
                        14.3.4.3 Financial Overview
                        14.3.4.4 Strategic Overview
                        14.3.4.5 SWOT Analysis
               14.3.5 Japan Blood Products Organization
                        14.3.5.1 Company Details
                        14.3.5.2 Business Overview
                        14.3.5.3 Strategic Overview
                        14.3.5.4 SWOT Analysis
               14.3.6 Mochida Pharmaceutical Co., Ltd. 
                        14.3.6.1 Company Details
                        14.3.6.2 Business Overview
                        14.3.6.3 Financial Overview
                        14.3.6.4 Strategic Overview
                        14.3.6.5 SWOT Analysis
               14.3.7 BIOFAC A/S
                        14.3.7.1 Company Details
                        14.3.7.2 Business Overview
                        14.3.7.3 Strategic Overview
                        14.3.7.4 SWOT Analysis
               14.3.8 Biomed-Lublin S.A.
                        14.3.8.1 Company Details
                        14.3.8.2 Business Overview
                        14.3.8.3 Financial Overview
                        14.3.8.4 Strategic Overview
                        14.3.8.5 SWOT Analysis
               14.3.9 Hualan Biological Engineering, Inc.
                        14.3.9.1 Company Details
                        14.3.9.2 Business Overview
                        14.3.9.3 Strategic Overview
                        14.3.9.4 SWOT Analysis

    List of Tables

    Table 01: Global Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
    Table 02: Global Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
    Table 02: Global Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
    Table 03: Global Thrombin Market Size (US$ Mn) Forecast, by Region, 2015–2025
    Table 04: North America Thrombin Market Size (US$ Mn) Forecast, by Country, 2015–2025
    Table 05: North America Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
    Table 06: North America Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
    Table 07: North America Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
    Table 08: Europe Thrombin Market Size (US$ Mn) Forecast, by Country/Sub-region, 2015–2025
    Table 09: Europe Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
    Table 10: Europe Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
    Table 11: Europe Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
    Table 12: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by Country/Sub-region, 2015–2025
    Table 13: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
    Table 14: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
    Table 15: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
    Table 16: Rest of the World Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
    Table 17: Rest of the World Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
    Table 18: Rest of the World Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
    Table 19: Johnson & Johnson Services, Inc.  Products & Services Offered
    Table 20: Pfizer, Inc.  Business Overview
    Table 21: Mallinckrodt Pharmaceuticals Business Overview
    Table 22: Shanghai RAAS blood products co., Ltd. Business Overview
    Table 23: Japan Blood Products Organization Business Overview
    Table 24: Mochida Pharmaceutical Co., Ltd. Business Overview
    Table 25: BIOFAC A/S Business Overview
    Table 26: Biomed-Lublin S.A. Business Overview
    Table 27: Hualan Biological Engineering, Inc. Business Overview

    List of Figures

    Figure 01: Global Thrombin Market Size (US$ Mn) Forecast, 2015–2025
    Figure 02: Market Value Share, by Region (2016)
    Figure 03: Market Value Share, by Product (2016)
    Figure 04: Market Value Share, by Dosage Form (2016)
    Figure 05: Market Value Share, by End User (2016)
    Figure 06: Global Thrombin Market Value Share Analysis, by Product, 2016 and 2025
    Figure 07: Global Thrombin Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, by Bovine Thrombin, 2015–2025
    Figure 08: Global Thrombin Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, by Human Thrombin, 2015–2025
    Figure 09: Global Thrombin Market Revenue (US$ Mn) and
    Figure 10: Global Thrombin Market Attractiveness Analysis, by Product, 2017–2025
    Figure 11: Global Thrombin Market Value Share, by Dosage Form, 2016 and 2025
    Figure 12: Global Thrombin Market Revenue (US$ Mn), by Powder Form, 2015–2025
    Figure 13: Global Thrombin Market Revenue (US$ Mn), by Solution Form, 2015–2025
    Figure 14: Global Thrombin Market Revenue (US$ Mn), by Others, 2015–2025
    Figure 15: Global Thrombin Market Attractiveness, by Dosage Form, 2015–2025
    Figure 16: Global Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
    Figure 17: Global Thrombin Market Revenue (US$ Mn), by Human Source, 2015–2025
    Figure 18: Global Thrombin Market Revenue (US$ Mn), by Diagnostic Centers & Clinics Source, 2015–2025
    Figure 19: Global Thrombin Market Revenue (US$ Mn), by Academic and Research Institutes, 2015–2025
    Figure 20: Global Thrombin Market Attractiveness Analysis, by End-user, 2015–2025
    Figure 21: Global Thrombin Market Value Share Analysis, by Region, 2016 and 2025
    Figure 22: Global Thrombin Market Attractiveness Analysis, by Region, 2015–2025 
    Figure 23: North America Thrombin Market Size (US$ Mn) and Y-o-Y Growth (%) Forecast, 2015–2025
    Figure 24: North America Thrombin Market Attractiveness Analysis, by Country, 2017–2025
    Figure 25: North America Thrombin Market Value Share Analysis, by Country, 2016 and 2025
    Figure 26: North America Thrombin Market Value Share Analysis, by Product, 2016 and 2025
    Figure 27: North America Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
    Figure 28: North America Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
    Figure 29: North America Thrombin Market Attractiveness Analysis, by Product,
    Figure 30: North America Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
    Figure 31: North America Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
    Figure 32: Europe Thrombin Market Size (US$ Mn) and Y-o-Y Growth (%) Forecast, 2015–2025
    Figure 33: Europe Thrombin Market Attractiveness Analysis, by Country/Sub-region, 2017–2025
    Figure 34: Europe Thrombin Market Value Share Analysis, by Country/Sub-region, 2016 and 2025
    Figure 35: Europe Thrombin Market Value Share Analysis, by Product, 2016 and 2025
    Figure 36: Europe Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
    Figure 37: Europe Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
    Figure 38: Europe Thrombin Market Attractiveness Analysis, by Product,
    Figure 39: Europe Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
    Figure 40: Europe Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
    Figure 41: Asia Pacific Thrombin Market Size (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, 2015–2025
    Figure 42: Asia Pacific Thrombin Market Attractiveness Analysis, by Country/Sub-region, 2017–2025
    Figure 43: Asia Pacific Thrombin Market Value Share Analysis, by Country/Sub-region, 2016 and 2025
    Figure 44: Asia Pacific Thrombin Market Value Share Analysis, by Product, 2016 and 2025
    Figure 45: Asia Pacific Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
    Figure 46: Asia Pacific Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
    Figure 47: Asia Pacific Thrombin Market Attractiveness Analysis, by Product,
    Figure 48: Asia Pacific Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
    Figure 49: Asia Pacific Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
    Figure 50: Rest of the World Thrombin Market Size (US$ Mn) and Y-o-Y Growth (%) Forecast, 2015–2025
    Figure 51: Rest of the World Thrombin Market Value Share Analysis, by Product, 2016 and 2025
    Figure 52: Rest of the World Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
    Figure 53: Rest of the World Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
    Figure 54: Rest of the World Thrombin Market Attractiveness Analysis, by Product,
    Figure 55: Rest of the World Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
    Figure 56: Rest of the World Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
    Figure 57: Thrombin Market: Heat Map Analysis by Company
    Figure 58: Johnson & Johnson Services, Inc. Breakdown of Net Sales (US$ Mn)
    Figure 59: Johnson & Johnson Services, Inc. R&D Intensity and Sales & Marketing Intensity (US$ Mn) - Company Level or Segment Level, 2015–2016
    Figure 60: Johnson & Johnson Services, Inc. Breakdown of Net Sales, by Region, 2017
    Figure 61: Johnson & Johnson Services, Inc. Breakdown of Net Sales, by Business Segment, 2017
    Figure 62: Pfizer Inc. revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2016
    Figure 63: Pfizer, Inc. R&D Intensity and Sales & Marketing Intensity (US$ Mn) - Company Level or Segment Level, 2015–2016
    Figure 64: Pfizer, Inc. Breakdown of Net Sales (2016), by Region
    Figure 65: Pfizer, Inc. Number of Discovery Projects till February 2016
    Figure 66: Mallinckrodt Pharmaceuticals Breakdown of Net Sales, by Business Segment, 2016
    Figure 67: Mallinckrodt Pharmaceuticals Revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2016
    Figure 68: Shanghai RAAS blood products co., Ltd. revenue (US$ Mn) and Y-o-Y Growth (%), 2013–2015
    Figure 69: Mochida Pharmaceutical Co., Ltd. revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2016
    Figure 70: Biomed-Lublin S.A. revenue (US$ Mn) and Y-o-Y Growth (%), 2015–2016
    Figure 71: Global Thrombin Market Revenue Split, By Product (2016)
    Figure 72: Global Thrombin Market Revenue Split, By Dosage Form (2016)
    Figure 73: Global Thrombin Market Revenue Split, By Region (2016)

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