Global Thrombin Market: Snapshot
Thrombin is serine protease blood plasma protein which converts fibrinogen into soluble fibrin to catalyze blood coagulation process. Globally commercially available therapeutic thrombin products are derived from bovine source, human plasma and genetic recombination (recombinant). Thrombin JMI, Evithrom, Recothrom, Thrombin Mochida, etc. are few approved hemostatic products in the USA and Japan. Thrombin is used in several medical surgeries in management of uncontrolled bleeding. Thrombin is also used in diagnostic centers and clinics in various applications such as clotting factor tests, coagulation assays, and defibrination of blood or plasma. R&D applications of thrombin includes in several research activities such as in vitro study, coagulation research, protein-structure analysis, medical research and biochemical research. Bovine thrombin is referred as thrombin fractionated from bovine blood. Thrombostat was the first bovine blood-based thrombin product approved by the U.S. FDA in 1943. Currently, there are few bovine thrombin brands available in market such as Thrombin JMI, Thrombi-Pad, and BioTrombina. Generally, bovine-based thrombin products have a black box warning due to the risk of abnormal hemostasis.
Demand for Bovine Thrombin to Rise at Considerably High Pace
Among the key product types, the bovine thrombin segment recorded surging demand and emerged as a key revenue contributor to the global thrombin market in 2016. TMR expects the global thrombin market to set sail on a growth path in response to the rising availability of bovine-based hemostatic brands such as Thrombin JMI. Besides this, the market will benefit from the rising adoption of bovine-based products in various research and diagnostic applications. Experts have also observed a spike in the recombinant thrombin uptake, which is attributed to lesser post-operative complications and safer hemostatic se in comparison to human and bovine thrombin.
In terms of end user, the hospital segment held the dominant share of 56.2% in the global market in 2016. The rising hemostatic use of thrombin-based products during surgeries has fuelled the demand for thrombin in the hospitals segment. In addition, the market is likely to witness lucrative growth prospects in the diagnostic centers and clinics segment, which held a considerable share in the global market in 2016.
North America and Asia Pacific Emerge as Lucrative Markets for Thrombin
Geographically, thrombin market has been segmented into major four regions: North America, Europe, Asia Pacific, and Rest of World. In 2016, North America and Asia Pacific accounted for the largest share of the thrombin market followed by Europe. The United States held a significant share of the thrombin market in North America, accounting for 94.2% share in 2016. Japan dominated the market in Asia Pacific in 2016 due to adoption of new thrombin therapies led by high awareness, significant health care spending in overall national budgets, early availability of advanced technologies, and extensive research activities in these countries. However, Europe is growing steadily while Asia Pacific is anticipated to grow faster during the forecast period due to major contribution from countries like Japan, India and China.
The global thrombin market is fragmented in nature with a dispersed presence of few players in various countries. Market players with high revenue base such as Pfizer Inc., Johnson & Johnson Services Inc., and Mallinckrodt Pharmaceuticals dominate the global thrombin market. Shanghai RAAS blood products co., Ltd., Japan Blood Products Organization, and Mochida Pharmaceutical Co., Ltd. are few key players operating in Asia Pacific region.
Rising Number of Road Accidents and an Increase in the Blood Clotting Disorders to Bring Good Growth Opportunities for the Thrombin Market
The thrombin market is expected to gain good growth opportunities across the forecast period of 2017-2025 on the back of factors such as rising obesity levels and expanding cases of blood clotting disorders. The increasing number of road accidents will also play a major role in the increase in the incidence of trauma and surgery numbers. All these factors bode well for the growth of the thrombin market.
The global thrombin market is segmented as follows:
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1. Preface
1.1 Report Scope
1.2 Market Segmentation
1.3 Research Highlights
2. Assumptions and Research Methodology
2.1 Assumptions
2.2 Acronyms Used
2.3 Research Methodology
3. Executive Summary
4. Market Overview
4.1 Product Overview
4.2 Key Industry Developments
4.3 Global Thrombin Market Size (US$ Mn) Forecast
4.4 Market Opportunity Map
4.5 Market Indicators
4.6 Porter’s Analysis
4.7 Global Thrombin Market Outlook
5. Market Dynamics
5.1 Drivers and Restraints Snapshot Analysis
5.2 Drivers
5.3 Restraints
5.4 Opportunities
5.5 Features of Ideal Hemostat at a glance
5.6 Key Brand Analysis
5.7 Regulatory Scenario
6. Global Thrombin Market Analysis, by Product
6.1 Key Findings
6.2 Introduction
6.3 Global Thrombin Market Value Share Analysis, by Product
6.4 Global Thrombin Market Forecast, by Product
6.4.1. Bovine Thrombin
6.4.2. Human Thrombin
6.4.3. Recombinant Thrombin
6.5 Global Thrombin Market Analysis, by Product
6.6 Global Thrombin Market Attractiveness Analysis, by Product
7. Global Thrombin Market Analysis, by Dosage Form
7.1 Key Findings
7.2 Introduction
7.3 Global Thrombin Market Value Share Analysis, by Dosage Form
7.4 Global Thrombin Market Forecast, by Dosage Form
7.4.1. Powder Forms
7.4.2. Solution Forms
7.4.3. Others
7.5 Global Thrombin Market Analysis, by Dosage Form
7.6 Global Thrombin Market Attractiveness Analysis, by Dosage Form
8. Global Thrombin Market Analysis, by End-user
8.1 Key Findings
8.2 Introduction
8.3 Global Thrombin Market Value Share Analysis, by End-user
8.4 Global Thrombin Market Forecast, by End-user
8.4.1. Hospitals
8.4.2. Diagnostics Centers & Clinics
8.4.3. Academics and Research Institutes
8.5 Global Thrombin Market Analysis, by End-user
8.6 Global Thrombin Market Attractiveness Analysis, by End-user
9. Thrombin Market Analysis, by Region
9.1 Global Thrombin Market Scenario
9.2 Introduction
9.3 Global Thrombin Market Value Share Analysis, by Region
9.3.1 North America
9.3.2 Europe
9.3.3 Asia Pacific
9.3.4 Rest of the World
9.4 Global Thrombin Market Forecast, by Region
9.5 Global Thrombin Market Attractiveness Analysis, by Region
10. North America Thrombin Market Analysis
10.1 Key Findings
10.2 North America Thrombin Market Overview
10.3 North America Thrombin Market Value Share Analysis, by Country
10.4 North America Thrombin Market Forecast, by Country
10.4.1. U.S.
10.4.2. Canada
10.5 North America Thrombin Market Value Share Analysis, by Product
10.6 North America Thrombin Market Forecast, by Product
10.7 North America Thrombin Market Value Share Analysis, by Dosage Form
10.8 North America Thrombin Market Forecast, by Dosage Form
10.9 North America Thrombin Market Value Share Analysis, by End-user
10.10 North America Thrombin Market Forecast, by End-user
10.11 North America Thrombin Market Attractiveness Analysis
11. Europe Thrombin Market Analysis
11.1 Key Findings
11.2 Europe Thrombin Market Overview
11.3 Europe Thrombin Market Value Share Analysis, by Country
11.4 Europe Thrombin Market Forecast, by Country
11.4.1 Germany
11.4.2 U.K.
11.4.3 France
11.4.4 Italy
11.4.5 Spain
11.4.6 Rest of the Europe
11.5 Europe Thrombin Market Value Share Analysis, by Product
11.6 Europe Thrombin Market Forecast, by Product
11.7 Europe Thrombin Market Value Share Analysis, by Dosage Form
11.8 Europe Thrombin Market Forecast, by Dosage Form
11.9 Europe Thrombin Market Value Share Analysis, by End-user
11.10 Europe Thrombin Market Forecast, by End-user
11.11 Europe Thrombin Market Attractiveness Analysis
12. Asia Pacific Thrombin Market Analysis
12.1 Key Findings
12.2 Asia Pacific Thrombin Market Overview
12.3 Asia Pacific Thrombin Market Value Share Analysis, by Country
12.4 Asia Pacific Thrombin Market Forecast, by Country
12.4.1 Japan
12.4.2 China
12.4.3 Australia & New Zealand
12.4.4 Rest of Asia Pacific
12.5 Asia Pacific Thrombin Market Value Share Analysis, by Product
12.6 Asia Pacific Thrombin Market Forecast, by Product
12.7 Asia Pacific Thrombin Market Value Share Analysis, by Dosage Form
12.8 Asia Pacific Thrombin Market Forecast, by Dosage Form
12.9 Asia Pacific Thrombin Market Value Share Analysis, by End-user
12.10 Asia Pacific Thrombin Market Forecast, by End-user
12.11 Asia Pacific Thrombin Market Attractiveness Analysis
13. Rest of the World Thrombin Market Analysis
13.1 Key Findings
13.2 Rest of the World Thrombin Market Overview
13.3 Rest of the World Thrombin Market Value Share Analysis, by Country
13.5 Rest of the World Thrombin Market Value Share Analysis, by Product
13.6 Rest of the World Thrombin Market Forecast, by Product
13.7 Rest of the World Thrombin Market Value Share Analysis, by Dosage Form
13.8 Rest of the World Thrombin Market Forecast, by Dosage Form
13.9 Rest of the World Thrombin Market Value Share Analysis, by End-user
13.10 Rest of the World Thrombin Market Forecast, by End-user
13.11 Rest of the World Thrombin Market Attractiveness Analysis
14. Competition Landscape
14.1 Competition Matrix
14.2 Thrombin Market: Heat Map Analysis by Company
14.3 Company Profiles
14.3.1 Johnson & Johnson Services, Inc.
14.3.1.1Company Details
14.3.1.1 Business Overview
14.3.1.2 Financial Overview
14.3.1.3 Strategic Overview
14.3.1.4 SWOT Analysis
14.3.2 Pfizer, Inc.
14.3.2.1 Company Details
14.3.2.2 Business Overview
14.3.2.3 Financial Overview
14.3.2.4 Strategic Overview
14.3.2.5 SWOT Analysis
14.3.3 Mallinckrodt Pharmaceuticals
14.3.3.1 Company Details
14.3.3.2 Business Overview
14.3.3.3 Financial Overview
14.3.3.4 Strategic Overview
14.3.3.5 SWOT Analysis
14.3.4 Shanghai RAAS blood products co., Ltd.
14.3.4.1 Company Details
14.3.4.2 Business Overview
14.3.4.3 Financial Overview
14.3.4.4 Strategic Overview
14.3.4.5 SWOT Analysis
14.3.5 Japan Blood Products Organization
14.3.5.1 Company Details
14.3.5.2 Business Overview
14.3.5.3 Strategic Overview
14.3.5.4 SWOT Analysis
14.3.6 Mochida Pharmaceutical Co., Ltd.
14.3.6.1 Company Details
14.3.6.2 Business Overview
14.3.6.3 Financial Overview
14.3.6.4 Strategic Overview
14.3.6.5 SWOT Analysis
14.3.7 BIOFAC A/S
14.3.7.1 Company Details
14.3.7.2 Business Overview
14.3.7.3 Strategic Overview
14.3.7.4 SWOT Analysis
14.3.8 Biomed-Lublin S.A.
14.3.8.1 Company Details
14.3.8.2 Business Overview
14.3.8.3 Financial Overview
14.3.8.4 Strategic Overview
14.3.8.5 SWOT Analysis
14.3.9 Hualan Biological Engineering, Inc.
14.3.9.1 Company Details
14.3.9.2 Business Overview
14.3.9.3 Strategic Overview
14.3.9.4 SWOT Analysis
List of Tables
Table 01: Global Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 02: Global Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
Table 02: Global Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 03: Global Thrombin Market Size (US$ Mn) Forecast, by Region, 2015–2025
Table 04: North America Thrombin Market Size (US$ Mn) Forecast, by Country, 2015–2025
Table 05: North America Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 06: North America Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
Table 07: North America Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 08: Europe Thrombin Market Size (US$ Mn) Forecast, by Country/Sub-region, 2015–2025
Table 09: Europe Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 10: Europe Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
Table 11: Europe Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 12: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by Country/Sub-region, 2015–2025
Table 13: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 14: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
Table 15: Asia Pacific Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 16: Rest of the World Thrombin Market Size (US$ Mn) Forecast, by Product, 2015–2025
Table 17: Rest of the World Thrombin Market Size (US$ Mn) Forecast, by Dosage Form, 2015–2025
Table 18: Rest of the World Thrombin Market Size (US$ Mn) Forecast, by End-user, 2015–2025
Table 19: Johnson & Johnson Services, Inc. Products & Services Offered
Table 20: Pfizer, Inc. Business Overview
Table 21: Mallinckrodt Pharmaceuticals Business Overview
Table 22: Shanghai RAAS blood products co., Ltd. Business Overview
Table 23: Japan Blood Products Organization Business Overview
Table 24: Mochida Pharmaceutical Co., Ltd. Business Overview
Table 25: BIOFAC A/S Business Overview
Table 26: Biomed-Lublin S.A. Business Overview
Table 27: Hualan Biological Engineering, Inc. Business Overview
List of Figures
Figure 01: Global Thrombin Market Size (US$ Mn) Forecast, 2015–2025
Figure 02: Market Value Share, by Region (2016)
Figure 03: Market Value Share, by Product (2016)
Figure 04: Market Value Share, by Dosage Form (2016)
Figure 05: Market Value Share, by End User (2016)
Figure 06: Global Thrombin Market Value Share Analysis, by Product, 2016 and 2025
Figure 07: Global Thrombin Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, by Bovine Thrombin, 2015–2025
Figure 08: Global Thrombin Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, by Human Thrombin, 2015–2025
Figure 09: Global Thrombin Market Revenue (US$ Mn) and
Figure 10: Global Thrombin Market Attractiveness Analysis, by Product, 2017–2025
Figure 11: Global Thrombin Market Value Share, by Dosage Form, 2016 and 2025
Figure 12: Global Thrombin Market Revenue (US$ Mn), by Powder Form, 2015–2025
Figure 13: Global Thrombin Market Revenue (US$ Mn), by Solution Form, 2015–2025
Figure 14: Global Thrombin Market Revenue (US$ Mn), by Others, 2015–2025
Figure 15: Global Thrombin Market Attractiveness, by Dosage Form, 2015–2025
Figure 16: Global Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
Figure 17: Global Thrombin Market Revenue (US$ Mn), by Human Source, 2015–2025
Figure 18: Global Thrombin Market Revenue (US$ Mn), by Diagnostic Centers & Clinics Source, 2015–2025
Figure 19: Global Thrombin Market Revenue (US$ Mn), by Academic and Research Institutes, 2015–2025
Figure 20: Global Thrombin Market Attractiveness Analysis, by End-user, 2015–2025
Figure 21: Global Thrombin Market Value Share Analysis, by Region, 2016 and 2025
Figure 22: Global Thrombin Market Attractiveness Analysis, by Region, 2015–2025
Figure 23: North America Thrombin Market Size (US$ Mn) and Y-o-Y Growth (%) Forecast, 2015–2025
Figure 24: North America Thrombin Market Attractiveness Analysis, by Country, 2017–2025
Figure 25: North America Thrombin Market Value Share Analysis, by Country, 2016 and 2025
Figure 26: North America Thrombin Market Value Share Analysis, by Product, 2016 and 2025
Figure 27: North America Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
Figure 28: North America Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
Figure 29: North America Thrombin Market Attractiveness Analysis, by Product,
Figure 30: North America Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
Figure 31: North America Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
Figure 32: Europe Thrombin Market Size (US$ Mn) and Y-o-Y Growth (%) Forecast, 2015–2025
Figure 33: Europe Thrombin Market Attractiveness Analysis, by Country/Sub-region, 2017–2025
Figure 34: Europe Thrombin Market Value Share Analysis, by Country/Sub-region, 2016 and 2025
Figure 35: Europe Thrombin Market Value Share Analysis, by Product, 2016 and 2025
Figure 36: Europe Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
Figure 37: Europe Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
Figure 38: Europe Thrombin Market Attractiveness Analysis, by Product,
Figure 39: Europe Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
Figure 40: Europe Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
Figure 41: Asia Pacific Thrombin Market Size (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, 2015–2025
Figure 42: Asia Pacific Thrombin Market Attractiveness Analysis, by Country/Sub-region, 2017–2025
Figure 43: Asia Pacific Thrombin Market Value Share Analysis, by Country/Sub-region, 2016 and 2025
Figure 44: Asia Pacific Thrombin Market Value Share Analysis, by Product, 2016 and 2025
Figure 45: Asia Pacific Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
Figure 46: Asia Pacific Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
Figure 47: Asia Pacific Thrombin Market Attractiveness Analysis, by Product,
Figure 48: Asia Pacific Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
Figure 49: Asia Pacific Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
Figure 50: Rest of the World Thrombin Market Size (US$ Mn) and Y-o-Y Growth (%) Forecast, 2015–2025
Figure 51: Rest of the World Thrombin Market Value Share Analysis, by Product, 2016 and 2025
Figure 52: Rest of the World Thrombin Market Value Share Analysis, by Dosage Form, 2016 and 2025
Figure 53: Rest of the World Thrombin Market Value Share Analysis, by End-user, 2016 and 2025
Figure 54: Rest of the World Thrombin Market Attractiveness Analysis, by Product,
Figure 55: Rest of the World Thrombin Market Attractiveness Analysis, by Dosage Form, 2017–2025
Figure 56: Rest of the World Thrombin Market Attractiveness Analysis, by End-user, 2017–2025
Figure 57: Thrombin Market: Heat Map Analysis by Company
Figure 58: Johnson & Johnson Services, Inc. Breakdown of Net Sales (US$ Mn)
Figure 59: Johnson & Johnson Services, Inc. R&D Intensity and Sales & Marketing Intensity (US$ Mn) - Company Level or Segment Level, 2015–2016
Figure 60: Johnson & Johnson Services, Inc. Breakdown of Net Sales, by Region, 2017
Figure 61: Johnson & Johnson Services, Inc. Breakdown of Net Sales, by Business Segment, 2017
Figure 62: Pfizer Inc. revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2016
Figure 63: Pfizer, Inc. R&D Intensity and Sales & Marketing Intensity (US$ Mn) - Company Level or Segment Level, 2015–2016
Figure 64: Pfizer, Inc. Breakdown of Net Sales (2016), by Region
Figure 65: Pfizer, Inc. Number of Discovery Projects till February 2016
Figure 66: Mallinckrodt Pharmaceuticals Breakdown of Net Sales, by Business Segment, 2016
Figure 67: Mallinckrodt Pharmaceuticals Revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2016
Figure 68: Shanghai RAAS blood products co., Ltd. revenue (US$ Mn) and Y-o-Y Growth (%), 2013–2015
Figure 69: Mochida Pharmaceutical Co., Ltd. revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2016
Figure 70: Biomed-Lublin S.A. revenue (US$ Mn) and Y-o-Y Growth (%), 2015–2016
Figure 71: Global Thrombin Market Revenue Split, By Product (2016)
Figure 72: Global Thrombin Market Revenue Split, By Dosage Form (2016)
Figure 73: Global Thrombin Market Revenue Split, By Region (2016)