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Altering Chemical Structure of Aptamers to Create New Opportunities for Manufacturers, says TMR

Posted on Sep 02, 2016

The global aptamers market is oligopolistic in nature, with a few key players, states a new report by Transparency Market Research (TMR). The top three players accounted for 57.8% of the market in 2012. Leading layers in the market have increased their R&D efforts in order to develop novel aptamers for therapeutics and diagnostics. For instance, companies such as NOXXON Pharma AG and Ophthotech Corporation are engaged in the development of novel aptamer products, which are in pipeline. The commercial availability of these products is expected to boost the market in the coming years. Key players in the market are Somalogic, Inc., Aptagen, Inc., Aptamer Sciences, Inc., Neo Ventures Biotechnology, Inc., and AM Biotechnologies, LLC.

According to the report, the global aptamers market is expected to be worth US$4,333.0 mn by 2019. On the basis of geography, North America not only led in the past, but is also expected to lead over the next few years, says TMR. North America is expected to account for 46.83% of the market by 2019, followed by Europe. An increase in the scientific research and development and the introduction of advanced SELEX processes for selection of novel aptamers are expected to be behind North America’s growth in the market.

Nucleic Acid Aptamers Segment to Lead owing to High Specificity

On the basis of type, the nucleic acid aptamers segment is expected to lead and be worth US$3,391.0 mn by 2019 owing to their distinct ability to selectively inhibit protein targets more specifically. Additionally, nucleic acid aptamers offer potential antagonist actions against various disease-associated proteins, are low in toxicity, and also provide high affinity ligands. By application, the therapeutics development segment is expected to lead by 2019. The characteristics of aptamers such as low toxicity and high stability and safety are increasingly drawing the attention of many biotechnology and pharmaceutical companies. Thus, the therapeutics development segment is expected to surge in the coming years.

Advancements in Technologies for Selection of Aptamers Drive Demand

Aptamers are special class of molecules with the benefit of having low molecular weight and are attractive solutions to research applications owing to their unique production methodology, thus driving their demand. Advancements in technologies for selection of aptamers are further expected to accelerate the growth of the market. A case in point would be Ellington Lab and Somalogic, Inc. These two companies have automated the process of in vitro aptamer selection and have developed a novel aptamer selection process that reduces the duration of aptamer selection experiment. Such developments are driving the global aptamers market.

Lack of Regulatory Guidelines Hinders Growth of Market

There is no regulatory guideline at the global level that specifically addresses the quality expected from aptamers. The regulatory expectation of aptamer-based drugs is still evolving. Thus, the development of regulatory guidelines, which satisfactorily address the quality and safety requirements for diverse class of molecules with a varied mechanism of action, is the need of the hour. Limited knowledge and technical expertise to understand and eliminate the unfavorable characteristics of aptamers is also affecting the growth of the market adversely.

Modification in Aptamer Chemistry to Boost Acceptance Levels

Aptamers can be modified to boost their therapeutic abilities and also to increase their life. The modification of the chemical structure of aptamers can also improve their nuclease resistance. Manufacturers can optimize the pharmacodynamics and pharmacokinetic properties of aptamers for better in vivo applications. Thus, focusing on altering the structure of aptamers will create new opportunities for manufacturers and help them earn more revenues.

This information is based on the findings of a report published by Transparency Market Research titled “Aptamers Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2013 - 2019.”

The global aptamers market is segmented as follows:

  • Types
    • Nucleic Acid Aptamers
    • Peptide Aptamers
  • Applications
    • Therapeutics Development
    • Diagnostics
    • Research and Development Application
    • Others
  • Geography
    • North America
    • Europe
    • Asia-Pacific
    • Rest of World (RoW)

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