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Increased Prevalence of the Disease Boosts Glioblastoma Multiforme Treatment Market

Glioblastoma multiforme refers to those malignant tumors that affect the spine or brain. This type of tumors grows and expands at a very rapid pace and it often creates extreme pressure. Glioblastoma multiforme is one of the most malignant and common type of the glial tumors. This type of tumor develops from star-shaped glial cells (oligodendrocytes and astrocytes), which encourages the overall health of the nerve cells inside the brain. Global glioblastoma multiforme treatment market is likely to gather momentum from the rising incidences of the disease across the globe.

In accordance with the U.S. National Cancer Institute, glioblastoma multiforme is one of the most aggressive types of cancer in the brain and it represents nearly 60% to 75% of all astrocytoma and 15.4% of all the primary brain tumors. This type of tumors exhibits rapid spread of benign cells within the organ.

Inability of Treatment Methods to Prolong Life Span of Patients to Spell Market Growth

The global glioblastoma multiforme treatment market is likely to observe substantial growth over the tenure of assessment due to expanding base of geriatric population and increased prevalence of oncology diseases.

Symptoms of glioblastoma multiforme comprise the following

  • Headache
  • Nausea
  • Drowsiness
  • Blurred vision
  • Personality changes
  • Seizures

Treatments of glioblastoma multiforme comprise surgery, chemotherapy, and radiation. However, the presence of treatment options fails to expand the overall survival rate of glioblastoma multiforme-stricken patients. Despite radiotherapy and chemotherapy, the survival rate of the patients does not increase. This factor is expected to encourage growth of the global glioblastoma multiforme treatment in the years to come.

In addition to that, glioma stem cells are capable of resisting the usual methods of treatments, which further drives the growth of the global glioblastoma multiforme treatment market over the assessment. Increased research and development in molecular biotechnology and gene therapy is further expected propel growth of the global glioblastoma multiforme treatment market.

Glioblastoma multiforme (GBM) is a high-grade gliomas and the most malignant astrocytic tumor, composed of complexly differentiated neoplastic astrocytes, a subtype of central nervous system (CNS). Glioblastoma is clinically classified as grade IV astrocytoma and differs from anaplastic astrocytoma (grade III) due to the presence of necrotic tissue and hyperplastic blood vessels. The diagnosis of GBM is carried out with imaging modules such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). In case of GBM treatment, there are many restraints and challenges such as its resistance against DNA-modifying agents, migration of malignant cells into adjacent brain tissues increases the complexity of the surgery, and current FDA approved treatments may cause neurotoxicity in patients. Thus, as available treatment options lack in efficiency, the mortality rate of glioblastoma is characterized by rapid progression and poor survival rate with only 8.7% of the patients surviving more than two years post diagnosis. According to Centers for Disease Control and Prevention (CDC), in 2011, approximately 22,000 adults in the U.S. were diagnosed with primary malignant tumors of the brain and spinal cord out of which gliomas accounted for the highest rate of incidence.
Although, the rising mortality rate of GBM has made it one of the lethal type of cancers; the pipeline of GBM is well equipped with various types of novel therapies including immunotherapy, biologics, small molecules and other drugs. The pipeline of GBM is currently rich in number of various therapeutic drugs and devices that are expected to receive FDA approvals for conducting the clinical trials. The FDA approved drugs currently present in market are temozolomide (Temodar, Temodal and Temcad), bevacizumab (Avastin) and carmustine wafers (BiCNU). The geographical segmentation of GBM market comprises North America, Europe, Asia Pacific and Rest of the World. Bevacizumab (Avastin) is the latest addition to this artillery, while temozolomide was leading the GBM market in 2013 due to it’s effectiveness when combined with surgery. Bevacizumab is the first monoclonal antibody drug approved for GBM treatment which is more efficient than temozolomide and is expected to surpass its revenue by 2016. Temozolomide market was drastically affected in 2013 as it has lost the market exclusivity in 2012 and generics manufactured by Teva Pharmaceutical Industries Ltd, and Sun Pharmaceutical Industries Ltd. entered the market. Geographically, in 2013 North America was observed as the most leading GBM market due to increasing support from government and non-government organizations to raise public awareness by and advanced healthcare infrastructure to boost the pipeline research in this market. Asia Pacific is the fastest growing market, rising awareness against GBM is boosting the diagnostic rate in this region and developing healthcare infrastructure is also assisting the market growth.
The pipeline analysis of GBM treatment include biologics, small molecules, devices, surgeries, and immunotherapy. In the current scenario, the pipeline review of glioblastoma seems to be strong as more than 50 molecules are in phase I and phase II clinical trials. The most promising drugs in phase III trials are Rindopepimut or CDX-110 (Celldex Therapeutics) and DCVax-L (Northwest Biotherapeutics). These molecules have performed well in phase II of the clinical trials in terms of exceeding the overall survival rate. 
The key players involved in the GBM market are Abbvie, Inc., Celldex Therapeutics, Inc., Exellixis, Inc., Brostol-Myers Squibb Co. and F. Hoffman La Roche. In 2013, F. Hoffman La Roche was observed to be the most promising and efficient source of GBM treatment due to its novel drug delivery system known as “brain shuttle.

Glioblastoma multiforme (GBM) is the most frequent and lethal primary brain tumor in adults. The current treatment modalities available in the market are surgical resection followed by chemotherapy and radiotherapy, that unable to increase the overall survival of patient. The main reason behind inability of these treatments are frequent recurrence, invasiveness of GBM and resistance of glioma stem cells to conventional treatments. Therefore, novel alternative treatment strategies are desperately needed and pipeline of GBM already involves a mix of biological, immunotherapy, small molecules and other types of therapeutics. Recent advancements in molecular biology and gene technology have provided attractive novel treatment possibilities for the patients diagnosed with GBM.

This research report on the glioblastoma treatment market explains various advancements in this market and analyzes the global glioblastoma treatment market based on drugs (commercially available and pipeline) and geographic regions. The report comprises an elaborate executive summary, which includes a market snapshot that provides market dynamics of various segments and sub-segments dominating the market and expected to grow at the highest growth rate during the forecast period are included in the report in a precise manner.
A detailed qualitative analysis of the factors responsible for driving and restraining the growth of the global glioblastoma treatment market and future opportunities has been provided in the market overview section. This section of the report also provides market attractiveness analysis and Porter’s Five Forces analysis and key players’ market share analysis in 2013 in the glioblastoma treatment market. The research report also provides event impact analysis and various drug delivery methods such as nucleic acid delivery method and biomedical delivery method for the treatment of glioblastoma. 
Based on drugs, the global glioblastoma treatment market has been segmented into Bevacizumab (Avastin), Temozolomide (Temodar and Temodal and Temcad) and Carmustine (BiCNU). The market for these drugs has been extensively analyzed based on consistency, effectiveness, and sales revenue of the drugs developed by the manufacturers. The market size and forecast in terms of USD million for each drug has been provided for the period from 2012 to 2022. The report on glioblastoma market also provides % compound annual growth rate (CAGR) for each of the market segments mentioned above for the forecast period from 2014 to 2022, considering 2013 as the base year. 
Based on pipeline review, the global glioblastoma treatment market has been segmented into late stage (phase III) and early stage (Phase I&II).  Drugs available in phase I and II are shown in a tabular format (significance, indication and intervention etc.). Likewise, the market size and forecast in terms of USD million for phase III candidate has been forecasted from 2014 to 2022. The report on the glioblastoma treatment market also provides % compound annual growth rate (CAGR) for each of the phase III molecules individually for the forecast period from 2014 to 2022. 
Geographically, the glioblastoma treatment market has been categorized into North America, Europe, Asia-Pacific and Rest of the World. The market size and forecast for each of these regions have been provided for the period from 2012 to 2022 along with CAGR (%) for the forecast period from 2014 to 2022. 
A list of recommendations has been provided for new entrants to help establish a strong presence and for existing market players to increase their market shares. The report concludes with the profiles of major players in the glioblastoma treatment market based on various attributes such as company overview, financial overview, business strategies, product portfolio and recent developments. Major players profiled in this report include AbbVie, Inc., Activartis Biotech GmbH, Bristol-Myers Squibb Co., Merrimack Pharmaceuticals, Inc., F. Hoffman La Roche, and Tau Therapeutics.   
The pipeline review of glioblastoma treatment market has been segmented as below:
  • Global Glioblastoma Treatment Market Revenue and Forecast, by Drugs
    • Bevacizumab (Avastin)
    • Temozolomide (Temodar and Temodal and Temcad)
    • Carmustine (BiCNU)
  • Global Glioblastoma Treatment Market Revenue and Forecast, by Geography
    • North America
    • Europe
    • Asia Pacific
    • Rest of the World
  • Global Pipeline Review of Glioblastoma Treatment
    • Overview
    • Late Stage (Phase III)
      • DCVax
      • Rindopepimut (CDX-110)
      • Others
    • Early Stage (Phase I, II and Pre clinical)
      • ABT-414
      • MM-398
      • ARC-100
      • AV0113
      • Cotara
      • Crenolanib
      • SGT-53
      • Endostatin
      • ANG1005
    • Others

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Pipeline Review Of Glioblastoma Treatment Market

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