Nonalcoholic Steatohepatitis Therapeutics Market: Overview
The nonalcoholic fatty liver diseases (NAFLD) at times may lead to nonalcoholic steatohepatitis (NASH), which is a chronic condition that may be as severe to be fatal as well. To avoid these conditions, there is an urgent demand of nonalcoholic steatohepatitis therapeutics in the global market. Another reason for the rise in demand for nonalcoholic steatohepatitis therapeutics is the increase in the number of people suffering from obesity and diabetes, which damages the liver. The disease is more prevalent in western nations. Although the symptoms of is found almost in all the regions and other demographics, the disease still prevails in younger children. The initial stage of cirrhosis can be cured with proper treatments and medications, for which the healthcare centers and physicians need proper therapeutics. This boosts the market growth significantly for nonalcoholic steatohepatitis (NASH) therapeutics in the market.
The several factors affecting the market demand is also contributing in the global expansion in coming years with a significant CAGR of 10.7% during the forecast period from 2015 to 2025. The market value is also estimated to be worth US$ 20.27 bn by the end of predicted time frame 2025. The rise in over-weight people and the cases of diabetes in the US people are prevailing steadily boosting the market demand for nonalcoholic steatohepatitis therapeutics.
Increased cases of Diabetes and Obesity Stirs up the Market Demand
The rise in number of cases suffering from NAFLD and NASH are quite common all over the globe. However, the number increases in developed economies such as North America. This gives a perfect scope to the firms and research centers looking to invest in the market. Not just that, the population of children suffering from obesity has increased almost thrice in number in past few years that calls for the urgent treatment methods to keep a check and cure the disease in its initial stages. People in America also suffer commonly from high cholesterol levels in their body. Although, there is no exact cure for the disease, the treatment are still being developed and worked upon. Moreover, the advancement in technology and the continuous effort by the research firms to find out a more effective treatment methods drives the market growth of nonalcoholic steatohepatitis therapeutics.
Developed Economies Serve as a Fertile Ground for Growth in Nonalcoholic Steatohepatitis Therapeutics
Based on the type of drug, the global market is segmented into potential phase III candidates for example Obeticholic acid (OCA), Saroglitazar, Elafibranor, and Aramchol. Elafibranor demonstrate the highest growth rate, accounting to maximum shares in the market. The drug is favored widely as it is the most advanced drug discovered till now that helps in reducing the effects of the disease. Obeticholic acid (OCA) follows Elafibranor in terms of most used drug and market revenue. There are other drugs as well in phase I and phase II trials.
On the basis of geographical regions, the market is segmented into North America, Middle East and Africa, Latin America, Europe, and Asia Pacific. Europe and North America regiona re the major regions being affected by NASH due to increase in population suffering from diabetes and obesity. Moreover, prevailing cases of high cholesterol, change in lifestyle, also makes North America a fertile ground for the future scope of development and market growth. In Europe region, countries such as Italy, Spain, Germany, the UK and France are the major areas where the disease is prevalent. They serve as high growth areas for of nonalcoholic steatohepatitis therapeutics market.
Intercept Pharmaceuticals Inc., GENFIT SA, Zydus Cadila, Conatus Pharmaceuticals, and Tobira Therapeutics, Inc., Astazeneca Plc., Galmed Pharmaceuticals Ltd., Gilead Sciences, Inc., and Immuron Ltd. are some of the major companies leading the nonalcoholic steatohepatitis therapeutics market. All of them and even new entrants are striving to develop more effective treatment for NASH disease.
Nonalcoholic fatty liver disease (NAFLD) is a disorder categorized by excess fat in the liver of people who drink little to no alcohol. No direct cause has yet been identified, however obesity and insulin resistance are believed to have major roles. Most often, NAFLD goes relatively undetected, as a liver can remain fatty without obstructing its function. Though, NAFLD can progress into a far more severe condition known as nonalcoholic steatohepatitis (NASH), a disease characterized by inflammation and irreversible cell death. NASH is a disease that advances over time. Over a period of ten years up to 20% of patients with NASH develop cirrhosis of the liver, and 10% die from the disease. At present, NASH is one of the leading causes of liver transplants in the U.S., with a considerable proportion of the general population currently suffering from the disease. NAFLD and NASH are both closely related to diabetes and obesity, and together are now considered as the leading cause of liver disease in Western countries. Thus, there is an urgent need for effective treatment options for these diseases. The need for treatment is expected to propel the growth of NASH therapeutics in coming years.
The NASH market is segmented based on drug type which includes potential phase III candidates such as Obeticholic acid (OCA), Aramchol, Saroglitazar and Elafibranor. Moreover, the report provides a list of the candidates in Phase I and Phase II clinical trials. Based on the drug type, Elafibranor is expected to account for a major share of this market followed by Obeticholic Acid (OCA) market and the market for Elafibranor is expected to grow at the highest CAGR.
The market overview section of the report demonstrates major market dynamics such as drivers, restraints, and opportunities that influence the current and future status of the industry. The market overview section includes epidemiology of Nonalcoholic steatohepatitis (NASH) by region, to provide a thorough analysis of the overall addressable global market for the NASH therapeutics. Moreover, the report provides qualitative information about diagnosis and treatment of NASH.
The report also provides important recommendations for market players and new entrants. These recommendations would enable existing market players to expand their market shares and help new companies to establish their presence in the NASH market across different regions worldwide. The report concludes with the company profiles section, which includes key information about major players in the market such as financial overview, business strategies, and recent developments.
Major players in this market are Astazeneca Plc (U.K.), Intercept Pharmaceuticals Inc. (U.S.), Galmed Pharmaceuticals Ltd. (Israel), GENFIT SA (France), Gilead Sciences, Inc. (U.S.), Zydus Cadila (India), Immuron Ltd. (Australia), Conatus Pharmaceuticals (U.S.), and Tobira Therapeutics, Inc. (U.S.).
The Nonalcoholic Steatohepatitis (NASH) Therapeutics market has been segmented as follows:
- Global Nonalcoholic Steatohepatitis (NASH) Therapeutics Market, By Drug Type
- Potential Drug Candidates in Phase III
- Obeticholic Acid (OCA)
- Aramchol (arachidyl amido cholanoic acid)