Protein tyrosine kinases (PTKs) are phosphotransferase enzymes that have the ability to transfer a phosphate group from adenosine triphosphate (ATP) to tyrosine amino acid residue which creates ADP (adenosine diphosphate) and phosphotyrosine. Phosphorylation of proteins triggers modifications in their enzymatic activity which can cause precise chemical responses. There are two classes of PTKs: cytoplasmic non-receptor PTKs (NRTKs) and transmembrane receptor PTKs. These non-receptor tyrosine kinases are non-specific, protein tyrosine kinases (PTKs) which are generally found in all metazoans. Hence, NRTKs are vital components of signaling pathways which have the ability to regulate important cellular functions such as apoptosis, survival, proliferation, and cell differentiation. Non-receptor tyrosine kinase inhibitors are small molecules, generally aromatic. These are appropriate drug targets for inflammatory, proliferative, neurodegenerative, and metabolic diseases. These non-receptor tyrosine kinase inhibitors bind to catalytic site of a non-receptor tyrosine kinase which prevents phosphorylation and helps to regulate cytostatic activity. The major classes of tyrosine kinases include Abelson murine leukemia (Abl) and Janus kinases (JAKs) & Src. The phosphorylation activity of non-receptor tyrosine kinase inhibitors is reversible, hence it is commonly used to regulate intracellular signals.
The simple difference between the non-receptor tyrosine kinase and receptor tyrosine kinase is the location. Non-receptor tyrosine kinase exist in cytoplasm of the cell, while receptor tyrosine kinase exist on the surface of cells, particularly cell membrane. In the past few years, non-receptor tyrosine kinase inhibitors (NRTKs) have emerged as one of the most encouraging therapeutics in different types of cancers. The advancements in the technical and theoretical knowledge of mechanism & functions of cell cycle, its enzymes helps to understand pathways for normal & tumorous cells growth, has led to substantial developments inhibitors which has the ability to stop or prevent cancerous cells growth in effected cells.
Non-receptor tyrosine kinase inhibitors (NRTKs) are considered capable and highly effective targeted therapy which aim to target malignant growth at its root and proliferative level. Additionally, these have created large opportunities for the pharma industry to research on variations seen in non-receptor tyrosine kinase inhibitor mechanisms and their precise role for the different types of metabolic and neurodegenerative disorders.
A robust clinical pipeline offers a promising situation in terms of future of precise therapeutic response from NRTKs. Increase in investments in research & development in the pharma & biotech sector has led to development of new innovative compounds, which are showing positive results in clinical trials. Some of the inhibitors are projected to be blockbuster drugs once launched in the market. The global non-receptor tyrosine kinase inhibitors market has significant growth potential. Moreover, the market is unexploited, particularly in developing countries such as India, Brazil, and Singapore. These countries are likely to witness high demand for effective drugs for inflammatory, proliferative, neurodegenerative, and metabolic diseases.
Geographically, the global non-receptor tyrosine kinase inhibitors market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the global market due to robust health care infrastructure, favorable reimbursement policies, presence of key players, and high acceptance of new techniques. Europe and Asia Pacific are the other major markets for non-receptor tyrosine kinase inhibitors. The market in Europe is anticipated to grow at a rapid pace due to brand loyalty, high investments in research and development by pharma companies, and existence of key players with differential offerings in the region. Developing countries such as India and Brazil have regulatory hurdles such as approvals for oncology trial procedures. Additionally, spending on coverage of medicines for cancer treatments and health insurance policies restrict usage of new technology in disease treatment.
Key players operating in the global non-receptor tyrosine kinase inhibitors market are Array Pharmaceuticals, AstraZeneca, Bristol-Myer Squibb, Novartis, Merck, and Pfizer, among others.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.