MEK Inhibitors Market to Create Opportunities in the Field of Oncology

  • Development of MEK inhibitors can serve as a new therapy to treat various malignancies. MEK inhibitors is a small molecule that inhibits mitogen-activated extracellular signal-regulated kinase. MEK inhibitors decrease the growth of tumor in people with metastatic melanoma by hindering the activity of MEK and BRAF kinases.
  • MEK inhibitors is a selective inhibitor of the MAPK pathways. It targets a non-ATP site of the Mitogen-activated protein kinases (MAP kinases). MAP kinases is a Serine/Threonine phosphorylating enzymes. MAP kinases is also known as Extracellular signal-regulated kinases (ERKs). Aberrant signaling through the MAPK pathway can cause cancer.

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Key Drivers and Restraints of Global MEK Inhibitors Market

  • Continuous clinical trials and studies on MEK inhibitors as a new treatment option in the field of oncology is expected to propel the MEK inhibitors market during the forecast period. Due to promising results of MEK inhibitors in skin cancer, researchers are actively involved in R&D on MEK inhibitors to expand its application to other invasive cancer indications, such as colorectal cancer. MEK inhibitors is under phase 3 study for the treatment of patients suffering from the metastatic colorectal cancer.
  • Rise in awareness about new treatment options and increase in incidences of melanoma across the globe are contributing to the growth of the global MEK inhibitors market. According to the American Institute for Cancer Research, in 2018, 300,000 new cases of skin cancer were reported.
  • High target affinity and specificity is another factor, which is expected to propel the MEK inhibitors market during the forecast period. Furthermore, product approval is a major driver for the global MEK inhibitors market.
  • In January 2019, ONO PHARMACEUTICAL CO., LTD. received manufacturing and marketing approval for MEKTOVI MEK inhibitors in Japan for the treatment of metastatic melanoma with BRAFV600 mutations
  • Stringent regulations on new therapeutics development and adverse effects of MEK inhibitors, such as rash, diarrhea, peripheral edema, fatigue, and dermatitis acneiform are likely to restrict the global MEK inhibitors market in the next few years

MEKINIST to Witness High Demand

  • On the basis of product, the global MEK inhibitors market can be divided into MEKINIST, COTELLIC, and MEKTOVI. The global MEL inhibitors market is driven by demand of MEKINIST. Combination therapy offers potent anti-tumor effects. Combination therapy helps to inhibit the BRAF kinase activity and the MEK1/MEK2 activity simultaneously.
  • Combination therapy has been approved for the treatment of adults suffering from metastatic melanoma with a BRAFv600 mutation

 Retail Pharmacies Segment has Significant Growth Potential

  • In terms of distribution channel, the global MEK inhibitors market can be divided into hospital pharmacies, retail pharmacies, and online pharmacies
  • Growth of the retail pharmacies segment can be attributed to the increase in the number of retail pharmacies across the globe and easy availability of small molecule MEK inhibitors at these stores
  • Moreover, availability of MEK inhibitors at specialty pharmacy stores in the U.S. and anticipated launch of new MEK inhibitors during the forecast period are likely to propel the growth of the retail pharmacies segment during the forecast period

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North America to Lead Global MEK Inhibitors Market

  • In terms of region, the global MEK inhibitors market can be divided into: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa
  • North America is leading the MEK inhibitors market due to factors such as increase in prevalence of NSCLC and melanomas and rise in sales of approved MEK inhibitors
  • In May 2017, ONO PHARMACEUTICAL CO., LTD.  and Array BioPharma Inc. signed a license agreement to develop and commercialize MEKTOVI in the U.S. and Canada
  • Asia Pacific is likely to witness maximum demand for MEK inhibitors from 2019 to 2027. Major manufacturers of MEK inhibitors have been investing increasingly in China and India due to a large patient base.
  • MEKTOVI application is submitted in The Swiss Medicines Agency (Swissmedic) and The Australian Therapeutics Goods Administration (TGA)  for marketing authorization of MEKTOVI
  • Survey of Ministry of Health, Labor and Welfare of Japan reported that around 4,000 patients are suffering from melanoma while about 700 deaths occur per year in Japan due to melanoma.
  • Leading manufacturers of MEK inhibitors have extensive distribution networks, along with deep product penetration. The manufacturers of MEK inhibitors are actively participating in trade fairs and international conferences to promote their products and develop potential R&D collaborations and distribution partnerships.

Key Manufacturers Operating in Global Market

The global MEK inhibitors market was highly consolidated in 2018. Key manufacturers operating in the global market are:

  • ONO PHARMACEUTICAL CO., LTD.
  • AstraZeneca
  • F. Hoffmann-La Roche Ltd
  • Novartis AG
  • Pfizer Inc.

Global MEK Inhibitors Market: Research Scope

Global MEK Inhibitors Market, by Product

  • MEKINIST (Trametinib)
  • COTELLIC (Cobimetinib)
  • MEKTOVI (Binimetinib)
  • Others

Global MEK Inhibitors Market, by Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

Global MEK Inhibitors Market, by Region

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • U.K.
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC
    • South Africa
    • Rest of Middle East & Africa

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The study is a source of reliable data on:

  • Market segments and sub-segments
  • Market trends and dynamics
  • Supply and demand
  • Market size
  • Current trends/opportunities/challenges
  • Competitive landscape
  • Technological breakthroughs
  • Value chain and stakeholder analysis

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

  • A complete backdrop analysis, which includes an assessment of the parent market
  • Important changes in market dynamics
  • Market segmentation up to the second or third level
  • Historical, current, and projected size of the market from the standpoint of both value and volume
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Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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