Melanoma is a form of skin cancer. Some of the major risk factors for melanoma are high levels of exposure to ultraviolet (UV) light leading to blistering sunburns, especially among population groups who are either in countries, which are in proximity to the equator or at very high altitudes.
According to the American Academy of Dermatology, the prevalence of melanoma is gradually increasing and rapidly spreads to other parts of the body. However, if melanoma is detected at an early stage i.e. in situ or stage 0. In this stage, the cure rate with surgical removal is nearly 100i% without any delays in seeking treatment; the survival rates from the disease are nearly 100 percent. When melanoma has spread to other body parts or has penetrated deeper into the skin or spreads, the treatment often becomes more complex. Hence, the systemic drug therapy for melanoma largely depends on the properties and stage at which melanoma is detected.
Since, 2011 various drugs have received FDA approval for treatment of melanoma. The melanoma drugs market has been segmented based on type of drug therapy into chemotherapy, immunotherapy and, targeted therapy. Immunotherapy works on the mechanism of stimulating persons own immune system response to distinguish cancer cells from normal cells more efficiently. A number of types of immunotherapy treatments can be used to treat melanoma. During the past few years, many new immunotherapy drugs for melanoma have entered the market. Immunotherapy drugs for melanoma include Keytruda(pembrolizumab) and Opdivo (nivolumab) which got FDA approval in 2014. Above mentioned drugs target PD-1, a protein on immune system cells called T cells. By blocking PD-1 protein, these drugs increase the immune response of the body against melanoma cells. Recently, the FDA approval of Yervoy (ipilimumab) in October 2015 has opened new market opportunities for market expansion of immunotherapy drugs in melanoma drugs market. Ipilimumab (Yervoy) is also another type of drug that upsurges immune response. However, it blocks CTLA-4, another protein on T cells.
These drugs are given as an intravenous (IV) infusion every 2 or 3 weeks. This results in shrinking of tumor. This treatment can help number of people with stage IV melanoma to live longer. However, it’s not yet clear if these drugs can completely cure melanoma.
These drugs act as checkpoint inhibitors to fight against melanoma cancer. In addition, there is a strong pipeline for melanoma treatment drugs under development by major key players and other new entrants in this market. Thus, taking into consideration the strategic new product launches after FDA approval the melanoma drugs market is expected to grow exponentially.
Similarly the Cytokines are proteins in the body that increase the immune system. Artificial cytokines, such as interferon-alfa and interleukin-2 (IL-2), are occasionally used in patients with melanoma.
When chemotherapy drugs fail to deliver positive results in melanoma patients, targeted therapy drugs are administered to them. The targeted therapy drugs include BRAF inhibitors such as Zelboraf (vemurafenib) and Tafinlar (dabrafenib). The BRAF drugs work on the mechanism of shrinking tumors among those metastatic melanoma patients who have undergone genetic mutation. They are found to increase the progression free survival rate of patients. The MEK inhibitors such as trametinib (Mekinist) and cobimetinib (Cotellic) block the MEK proteins. In November 2015, Cotellic (cobimetinib) of Genentech Inc. received approval from FDA for the treatment of BRAF V600E or V600K melanoma. Generally Cotellic is used in combination with vemurafenib, a BRAF inhibitor, to treat melanoma.
On October 27th 2015, Amgen Inc.’s Oncolytic virus therapy for a deadly form of skin cancer/ melanoma was approved by U.S. FDA. The drug is known as talimogene laherparepvec, or T-vec, was cleared as a treatment for melanoma lesions in the skin and lymph nodes that can’t be removed completely by surgery. According to FDA brand-name of the drug is Imlygic. It uses adapted version of the herpes simplex virus to attack cancerous cells. After being injected into the tumor, the virus replicates until it causes the cells to breach and it results in provoking an immune system response that communicates the body to recognize the cancer.
Targeted therapy drugs have lower severity of side effects compared to other melanoma cancer drugs. However, despite of the new market opportunities created as a result of recent FDA approvals, some of the major restraints in the market are attributed to the lack of innovative and successful therapies in the market to reduce the risk of mortality of advanced metastatic melanoma patients. Thus, targeted therapy and their combinations could lead the melanoma drugs market and play a potential role in driving in melanoma drug market.
Some of the major players in this market include Amgen, Inc., Bristol-Myers Squibb, Eisai Co. Ltd., F. Hoffmann-La Roche Ltd., Genentech Inc. Janssen Biotech, Inc., and Novartis International AG. Pfizer, Vical and ZIOPHARM.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.