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Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder, a common ailment that affects the colon. Some of the effects of IBS are gas, bloating, pain, constipation, and diarrhea. Long term management is required for IBS as it is a chronic condition. The symptoms of IBS can be controlled by bringing about changes in lifestyle and daily diet and by tackling stress if any. Severe signs and symptoms of IBS can be observed in very small groups of people who need treatment and counseling.

One among every five Americans have signs and symptoms of irritable bowel syndrome and very few seek medical assistance. Although classified as non-threatening, with an approximately 11% prevalence rate, irritable bowel syndrome is one of the most common GI disorders. IBS mostly occurs in people below the age of 45 and is twice more prevalent in women compared to men. Serious symptoms of IBS include rectal bleeding, weight loss, and severe abdominal pain in the night.

Based on the predominant symptoms, IBS can be classified into 3 types – IBS-D where diarrhea is the predominant symptom, IBD-C where constipation is the predominant symptom, and IBS-M with mixed symptoms. Common triggers for irritable bowel syndrome include food, hormones, stress, and other illness such as gastroenteritis and over growth of intestinal bacteria.

As the cause of irritable bowel syndrome is not clear, treatment is mainly focused on relieving the symptoms of IBS so that patients can live a normal life. Mild irritable bowel syndrome can be managed by changes in lifestyle and diet, whereas moderate to severe IBS requires medication. First line treatment for all types of IBS include dietary modification, exercise, counselling, and avoiding the triggers. If these treatment options do not help, anti-diarrheal drugs for IBS-D, and laxatives and fiber supplements for IBS-C are used. Antispasmodic are used to reduce the pain associated with IBS. However, overall relief provided by the mentioned treatments are not satisfactory and usually lead to adverse effects.

A number of new promising therapies that provide overall relief for IBS are being launched. Lotronex, a 5-HT3 antagonist launched in February 2000 by GlaxoSmithKline is effective in treating all the symptoms of IBS-D but was withdrawn from the market due to adverse reactions. It was subsequently reintroduced into the market in July 2002 to treat severe IBS only in women when all other therapies fail.

Some of the major drivers of the IBS drugs market are the rise in disease prevalence of IBS, increase in stress levels and lifestyle changes, favorable healthcare reimbursement policies, rise in healthcare investment, and rich late phase products pipeline. Restraints of the IBS drugs market include unsatisfactory effectiveness of the drugs, improper disease awareness, and low diagnosis of IBS.

On the basis of medication, the IBS drugs market is mainly divided into three types - drugs for the treatment of IBS-D such as Opioid µ-Receptor agonists, smooth-muscle relaxants, tricyclic antidepressants, and selective 5-HT3 receptor antagonists. Drugs for the treatment of IBS-C include bulking agents, osmotic laxatives, and drugs used to relieve pain such as smooth-muscle relaxants and tricyclic antidepressants. Currently, Lotronex and Amitiza are the only products available in the market approved by the U.S. FDA. With constant developments in understanding the pathophysiology of the disease, newer drugs with combined 5-HT3 antagonist and 5-HT4 agonist actions are under clinical advancement. Future therapies include Alizyme, Ramosetron, Dynogen etc. Better understanding of the pathophysiology of IBS has created opportunity for newer drugs in the market. Thus, it is more likely to foresee arrival of first class drug therapies in the near future, leading to fierce competition in the market.

On the basis of geography the IBS drugs market is divided into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America. North America is the pre-dominant market for IBS drugs due to ample opportunities with favorable reimbursement policies. However, Asia Pacific is the fastest growing market for IBS drugs with Japan developing as the major market for IBD drugs, awaiting drug approvals. Linzess launched in 2013 is the only product available for IBD-C in Germany and the U.K. In Italy, anti-depressants and Xifaxan are used off-label in IBS patients for the management of the disease, indicating the need for first line therapies in the European market.

Some of the key players in the irritable bowel syndrome market are Allergan Plc., Sucampo Pharmaceuticals, Lexicon Pharmaceuticals, Inc., Pfizer Inc. Astellas Pharma Inc., Ironwood Pharmaceuticals, Inc., Novartis, Ono Pharmaceutical Co., Ltd., Synergy Pharmaceuticals, Takeda Pharmaceutical Company Ltd, and Abbot Laboratories.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

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The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Irritable Bowel Syndrome Drugs Market

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