Liver is a vital organ that performs several important bodily functions including bile production for digestion, protein production, synthesis of blood clotting factors, storage of glucose (sugar) in the form glycogen, and detoxification. Also, the liver cells have a remarkable ability to regenerate themselves after any damage. Due to this unique capability, the liver tissues have fascinated the researchers. True understanding of molecular and cellular connectivity and functions of the liver tissues in an in-vivo as well as in-vitro setting is very important from the viewpoint of discovery science and clinical application. Development of liver models that can provide a virtual ecosystem that mimics the molecular processes of a liver factory can help understand molecular interactions to network dynamics and whole organ functions. These advanced liver models are mini-organs or organoids that are expected to replicate human liver physiology, anatomy, and functions from molecular layer upward. The formation of these living models is a fairly new area of science that has the potential to replace animal models. The human liver models offer several advantages over animal models that are not always accurate and pose ethical issues. The human liver models or organoids have been used to screen new drugs for liver toxicity. These models are also being deeply studied to build a functional model of human liver development. The process of making a human liver model starts with a fetal liver progenitor cell, an immature cell that transforms into a specialized liver cell. The fetal liver progenitor cell is allowed to self-assemble in a small disc. These discs are composed of ferret liver cells that are pre-processed to remove all cells of the ferret. The resultant mini-organ models the actual human liver development. These models have been observed to generate hepatocytes, the basic functional cells of the liver, which is expected to produce the functional bioengineered liver tissues for transplantation into patients in the near future.
The global human liver models market can be segmented based on platform type and region. In terms of platform type, the market can segmented into liver organoids, animal models, 2D models, liver-on-a-chip, and 3D bio-printed models. As animal models are crucial for studying the disease progression in humans, the demand for animal models is expected to increase during the forecast period. However, liver-on-a-chip offers a simpler and inexpensive alternative for animal model and it is expected to be a rapidly expanding segment during the forecast period. Rising demand for developing substitutes for animal testing models, increasing prevalence of fatty liver disease, growing funding for research and development, and surging necessity for early detection of drug toxicity to minimize late-stage drug failure are some of the factors anticipated to drive the global human liver models market during the forecast period. Based on region, the global human liver models market can be divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America and Europe are projected to account for a prominent share of the market from 2018 to 2026, due to high expenditure on health care R&D, high adoption of innovative potential therapies, and introduction of technologically advanced products in these regions. The human liver models market in Asia Pacific is expected to expand at a significant rate during the forecast period, owing to increase in R&D funding in developing countries in the region. Key factors driving the global human liver models market are rapid development of health care infrastructure and high focus on research and development in the health care sector.
Some of the key players operating in the global human liver models market are Mimetas, InSphero, Organovo Holdings Inc., Ascendance Biotechnology, Emulate, Inc., CN Bio, and Cyfuse Biomedical.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.