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Advanced Methods of Cryopreservation Show Potential in Avoiding Passage of COVID-19

The onset of the COVID-19 pandemic has altered business processes in the global centrifugation-free sperm separation systems market. The risk of cross-contamination in cryobanks and IVF (In Vitro Fertilization) centers has surged due to the ongoing pandemic. As such, there is lack of any reported cases that suggest the production of a disease or the novel infection in a patient or a recipient of donor reproductive tissue.

Companies in the centrifugation-free sperm separation systems market are increasing awareness about their advanced methods for IVF and cryopreservation, which have the potential to avoid the passage of COVID-19 via fertility treatment. There is a growing awareness about the fact that ova and embryos are poor vectors for diseases. Moreover, liquid nitrogen sterilization methods hold promising potentials for minimizing viral exposure risks during cryostorage.

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Continuous R&D Necessary to Improve Microfluidics for Sperm Sorting

Microfluidic systems are playing an important role in the democratization of sperm sorting technologies, whilst improving the results of current sorting techniques. However, there is a lack of study and evidence that shows better outcome of IVF with sperm cells selected with a microfluidic sperm sorter. This explains why the centrifugation-free sperm separation systems market is slated to register a modest CAGR of ~4% during the assessment period. The ongoing research by companies is paving the way for paradigm shifts in sperm sorting technologies.

Active and passive selection methods are growing popular in microfluidic sperm sorters (MFSSs). This technique is increasingly replacing current technologies that are time consuming and help to meet growing demand for assisted reproductive technologies (ARTs).

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PMMA-based Microdevices Help in High-quality Sperm Selection

The selection of high-quality sperm is essential for successful IVF. This has led to the popularity of polymethyl methacrylate (PMMA)-based microdevice, which is being designed and fabricated for efficient sperm evaluation & screening. As human cervical mucus has high viscosity, but without enough swimming persistence, the human sperm clouds cannot arrive at the ampulla to fertilize the egg. Hence, companies in the centrifugation-free sperm separation systems market are increasing their focus in PMMA-based microdevices that help to evaluate the swimming capability of human sperm clouds and analyze their persistence in a viscous environment. Companies in the centrifugation-free sperm separation systems market are suggesting this device can achieve a one-stop procedure for high-quality sperm selection.

MS-based Sperm Processing Associated with Improved Motility in Sperm Fraction

The migration sedimentation (MS) of spermatozoa is expected to avoid the deleterious effects of centrifugation. Since MS is associated with improved motility in sperm fraction, companies in the centrifugation-free sperm separation systems market are taking cues from devices such as the one developed by Menicon Life Science, Japan. Companies are gaining a strong research base in devices made of transparent bio-compatible Cyclo olefin polymer made by the company.

Companies in the centrifugation-free sperm separation systems market are increasing the availability for MS-based sperm processing, which offers an alternative to traditional sperm selection techniques. This involves isolating enriched fraction of spermatozoa from an unprocessed ejaculate.

Isolation of Non-motile Sperm from Background Cell Contaminants Gains Importance

The rising trend of infertility worldwide is creating research opportunities for companies in the centrifugation-free sperm separation systems market. This is resulting in the demand for microfluidic technologies that show promising opportunities for male infertility treatment and growing demand for ARTs. Medical conditions such as obstructive azoospermia (OA) and non-obstructive azoospermia (NOA) are acting as key drivers for the expansion of the centrifugation-free sperm separation systems market.

Companies are developing motility-based sperm selection devices to enable laminar flow boundaries, chemotaxis, and rheotaxis in order to achieve effective sperm selection. As such, there is a growing need for methods and devices that focus on the isolation of non-motile sperm from background cell contaminants.

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Analysts’ Viewpoint

The MS is gaining popularity in assisted fertilization programs. However, its benefits to apply in assisted fertilization are not established with the adequate fundamental scientific evidence. Hence, companies are increasing their R&D efforts to develop disposable devices that are relatively inexpensive and intended to use without the need for special technical skills or equipment.

For men who undergo testicular surgery due to azoospermia, companies in the centrifugation-free sperm separation systems market are developing a microfluidic, 3D (3 dimensional) printed sperm separation device. This technology is gaining increased attention, since it allows technicians to recover sperm from biopsied tissue suspensions within few minutes. This helps to eliminate the hassles of human error associated with extended sample microscopy.

Centrifugation-free Sperm Separation Systems Market: Overview

  • Centrifugation-free sperm separation system is a simple, centrifugation-free, sperm-sorting device, which eliminates the risk of centrifugation in the swim-up method, while maintaining functional competence and DNA integrity of selected spermatozoa
  • Centrifugation-free sperm separation systems help to prevent centrifugation-induced damage to sperm. Based on motility and with the help of gravity, sperm cells can sediment at the bottom of a tube without centrifugation. Different types of technique used for centrifugation-free sperm separation are migration-sedimentation (MS), microfluidic sperm sorters (MFSSs), and others.
  • Increase in incidence of infertility in men and women, and rise in in-vitro fertilization procedures are projected to drive the global centrifugation-free sperm separation systems market
  • Incidence of infertility in men and women is gradually increasing across the globe. Several factors are responsible for infertility, including high alcohol consumption, smoking cigarettes, hormone imbalance, chronic diseases such as diabetes, lupus, arthritis, hypertension, and asthma; genetic problems, and others. Infertility affects millions of people of reproductive age globally and has an impact on their families and communities. According to the WHO, 90 million couples and 186 million individuals live with infertility globally.
  • Increase in in-vitro fertilization procedures drives the demand for centrifugation-free sperm separation systems. Rise in number of men and women with infertility increases the number of in-vitro fertilization procedures. Surge in demand for good quality sperm for in vitro fertilization procedures is likely to boost the growth of the market. According to the WHO, over 8 million children have been born through IVF globally, and around 2.5 million cycles are being performed every year, resulting in over 500,000 deliveries annually.

Market Segmentation: Centrifugation-free Sperm Separation Systems Market

  • In terms of technique, the global centrifugation-free sperm separation systems market has been classified into migration-sedimentation (MS), microfluidic sperm sorters (MFSSs), and others
  • Based on end user, the global centrifugation-free sperm separation systems market has been divided into hospitals & clinics, cryobanks, IVF centers, and others
  • Each of the segments has been analyzed in detail for centrifugation-free sperm separation systems trends, recent trends & developments, drivers, restraints, opportunities, and useful insights. The centrifugation-free sperm separation systems market report provides current and future revenue (US$ Mn) for each of these segments for the period from 2017 to 2031, considering 2019 as the base year. The compound annual growth rate (% CAGR) has been provided for each segment and market from 2021 to 2031 along with market size estimations.

Regional Overview: Centrifugation-free Sperm Separation Systems Market

  • In terms of region, the global centrifugation-free sperm separation systems market has been divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. The regions have been divided into major countries and sub-regions.
  • North America accounted for the largest share of the global centrifugation-free sperm separation systems market in 2019. The trend is expected to continue during the forecast period. Growth of the centrifugation-free sperm separation systems market in North America can be primarily ascribed to presence of major players, significant healthcare expenditure, early availability of new techniques, and increase in research activities across the country.
  • Asia Pacific is projected to gain market share during the forecast period. Product launches, acquisitions, distribution agreements, alliances, and geographical expansion by local players, especially in China and India, are expected to propel the centrifugation-free sperm separation systems market in the region. High infertility rate in countries such as India and China and rise in demand for centrifugation-free sperm separation systems drive the market in the region.
  • The current and future market sizes in terms of value (US$ Mn) of these regional markets and major countries have been provided in the report for the period from 2017 to 2031, along with CAGRs for the period from 2021 to 2031
  • The study also offers a list of recommendations, highlights, and useful insights of the market, which are estimated to help new companies willing to enter the market and existing companies to increase market share and in the decision-making process

Centrifugation-free Sperm Separation Systems Market Players

  • The report concludes with the company profiles section that includes key information about the major players in the global centrifugation-free sperm separation systems market
  • Leading players analyzed in the report are
    • CooperSurgical, Inc.
    • Koek Biotechnology Bioengineering and Medical Services Industry & Trade, Inc.
    • Memphasys Ltd.
    • DxNow
    • SAR Healthline Pvt. Ltd.
    • Lotus Bio
    • other prominent players
  • Each of these players has been profiled in the report based on parameters such as company overview, financial overview, business strategies, product portfolio, business segments, and recent developments

Centrifugation-free Sperm Separation Systems Market – Scope of the Report

TMR’s report on the global centrifugation-free sperm separation systems market studies the past as well as the current growth trends and opportunities to gain valuable insights of the indicators of the market during the forecast period from 2021 to 2031. The report provides revenue of the global centrifugation-free sperm separation systems market for the period of 2017–2031, considering 2019 as the base year and 2031 as the forecast year. The report also provides the compound annual growth rate (CAGR %) of the global centrifugation-free sperm separation systems market from 2021 to 2031.

The report has been prepared after an extensive research. Primary research involved bulk of the research efforts, wherein analysts carried out interviews with key opinion leaders, industry leaders, and opinion makers. Secondary research involved referring to key players’ product literature, annual reports, press releases, and relevant documents to understand the centrifugation-free sperm separation systems market.

Secondary research also included Internet sources, statistical data from government agencies, websites, and trade associations. Analysts employed a combination of top-down and bottom-up approaches to study various attributes of the global centrifugation-free sperm separation systems market.

The report includes an elaborate executive summary, along with a snapshot of the growth behavior of various segments included in the scope of the study. Moreover, the report sheds light on the changing competitive dynamics in the global centrifugation-free sperm separation systems market. These serve as valuable tools for existing market players as well as for entities interested in participating in the global centrifugation-free sperm separation systems market.

The report delves into the competition landscape of the global centrifugation-free sperm separation systems market. Key players operating in the global centrifugation-free sperm separation systems market are identified and each one of these is profiled in terms of various attributes. Company overview, financial standings, recent developments, and SWOT are the attributes of players in the global centrifugation-free sperm separation systems market profiled in this report.

Key Questions Answered in Centrifugation-free Sperm Separation Systems Market Report

  • What is the sales/revenue generated by centrifugation-free sperm separation systems across all regions during the forecast period?
  • What are the opportunities in the global centrifugation-free sperm separation systems market?
  • What are the major drivers, restraints, opportunities, and threats in the market?
  • Which regional market is set to expand at the fastest CAGR during the forecast period?
  • Which technique is expected to generate the highest revenue globally in 2031? Which segment is projected to expand at the highest CAGR during the forecast period?
  • What is the market position of different companies operating in the global market?

Centrifugation-free Sperm Separation Systems Market – Research Objectives and Research Approach

The comprehensive report on the global centrifugation-free sperm separation systems market begins with an overview, followed by the scope and objectives of the study. The report provides detailed explanation of the objectives behind this study and key vendors and distributors operating in the market and regulatory scenario for approval of products.

For reading comprehensibility, the report has been compiled in a chapter-wise layout, with each section divided into smaller ones. The report comprises an exhaustive collection of graphs and tables that are appropriately interspersed. Pictorial representation of actual and projected values of key segments is visually appealing to readers. This also allows comparison of the market shares of key segments in the past and at the end of the forecast period.

The report analyzes the global centrifugation-free sperm separation systems market in terms of technique, end user, and region. Key segments under each criteria are studied at length, and the market share for each of these at the end of 2031 has been provided. Such valuable insights enable market stakeholders in making informed business decisions for investment in the global centrifugation-free sperm separation systems market.

Centrifugation-free Sperm Separation Systems Market – Segmentation

TMR’s study on the global centrifugation-free sperm separation systems market includes information divided into three segments: technique, end user, and region. Changing industry trends and other crucial market dynamics associated with these segments of the global centrifugation-free sperm separation systems market are discussed in detail.

Technique
  • Migration-sedimentation (MS)
  • Microfluidic Sperm Sorters (MFSSs)
  • Others
End User
  • Hospitals & Clinics
  • Cryobanks
  • IVF Centers
  • Others
Region
  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

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