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Vascular Disrupting Agents Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025

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The process of formation of new blood vessels is called angiogenesis. Angiogenesis is essential for growth and multiplication of solid tumors. If size of the tumor is less than 2 mm3, growth factors and nutrients are supplied by diffusion. However, if the tumor size is larger, blood supply to the tumor needs to be established. Dependence of tumor cells on newly formed blood vessels for their growth and metastasis has resulted in focusing on ‘angiogenesis’ as a novel target for cancer treatment. Vascular disrupting agents is a new and promising class of targeted anticancer agents having antiangiogenic effect. These agents primarily act by disrupting the formed abnormal solid tumor vasculature by targeting the immature dysmorphic endothelial cells. They exert their anticancer effect by targeting new tumor blood vessels that are formed by angiogenesis, blocking the supply of blood to the formed tumor. This makes the tumor deprived of essential nutrients and oxygen, leading to tumor cell death. Vascular disrupting agents are primarily used in the treatment of different types of cancer such as ovarian cancer, thyroid cancer, liver cancer, colorectal cancer, glioblastoma, and renal cell carcinoma.

Vascular disrupting agents are of two types: small-molecule and ligand-directed vascular disrupting agents. Small-molecule vascular disrupting agents have been further classified into tubulin-binding agents and flavonoids. Tubulin binding agents act by selectively binding to the β-tubulin colchicine binding site, which weakens microtubules and leads to change in the 3-dimensional shape of endothelial cells. Endothelial cells interrupt the tumor blood vessel, thereby leading to necrosis of cancer cells within the tumor. Examples of tubulin-binding agents include combretastatin, crolibulin, verubulin, and fosbretabulin. The other type of small-molecule vascular disrupting agents are flavonoids, which promote localized release of the tumor necrosis factor TNFα from nearby activated macrophage cells. Examples of flavonoids include 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and icaritin/pexastimogene devacirepvec. Ligand-directed vascular disrupting agents primarily act by delivering toxic effects to tumor endothelium. The small-molecule vascular disrupting agents segment is expected to expand significantly during the forecast period, as a majority of molecules in the pipeline are small molecules. Additionally, high incidence and prevalence rate of cancer, increase in the demand for newer treatment options, and the large number of ongoing clinical trials boost the vascular disrupting agents market. However, unsatisfactory results of clinical trials and low availability of safety data restrain the vascular disrupting agents market.

In terms of geography, the global vascular disrupting agents market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America leads the global market, followed by Europe. Growth of the market in North America is attributable to high incidence and prevalence rate of cancer, rise in the geriatric population, and increase in the demand for advance treatment options in the region. Asia Pacific is an emerging market for vascular disrupting agents, due to developing health care infrastructure, increasing patient awareness, and rising government expenditure on health care in the region. However, low awareness among patients, high cost of therapy, and lack of availability of treatment options are factors restraining the vascular disrupting agents market in regions such as Middle East & Africa and Latin America.

Major players operating in the global vascular disrupting agents market include Mateon Therapeutics, Immune Pharmaceuticals, Nereus Pharmaceuticals, Madrigal Pharmaceuticals, Inc., Celgene Corporation, Bionomics Ltd., and Lees Pharmaceutical Holdings.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The study is a source of reliable data on:

  • Market segments and sub-segments
  • Market trends and dynamics
  • Supply and demand
  • Market size
  • Current trends/opportunities/challenges
  • Competitive landscape
  • Technological breakthroughs
  • Value chain and stakeholder analysis

The regional analysis covers:

  • North America (U.S. and Canada)
  • Latin America (Mexico, Brazil, Peru, Chile, and others)
  • Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
  • Eastern Europe (Poland and Russia)
  • Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
  • Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

  • A complete backdrop analysis, which includes an assessment of the parent market
  • Important changes in market dynamics
  • Market segmentation up to the second or third level
  • Historical, current, and projected size of the market from the standpoint of both value and volume
  • Reporting and evaluation of recent industry developments
  • Market shares and strategies of key players
  • Emerging niche segments and regional markets
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