Migraine is a commonly occurring disease across the globe. Triptans are a leading class of drugs prescribed in the treatment of migraine alone or as a combination therapy. These are the first line products for migraine for patients aged above 12 years. Various trials have proven the efficacy of triptans in the cure of the symptoms of migraine. Triptans are selective 5-hydroxytryptamine (5-HT) receptor agonists with high affinity for 5-HT1B and 5-HT1D receptors. The mechanisms of action of triptans are reduction of inflammation, vasoconstriction, and modeling of the second-order receptors. A range of triptan formulations is available for patients with slight variations in efficacy. The global triptans market is projected to grow at a rapid pace due to increase in global population, especially female population that is more prone to migraines. Innovations in drug delivery systems such as development of transdermal patches of triptan drugs which are proven to increase the efficacy of the drug are likely to present opportunities for players seeking to establish themselves in the global triptans market.
The global triptans market has a considerable room for growth in the absence of a permanent cure for the condition and growing generalization of drugs. Increase in research and development activities and expansion of the distribution network by the leading players across regions are projected to boost the growth of the global triptans market. However, easy availability of generics and over-reliance on over-the-counter (OTC) pain killers and other drugs in developing and under-developed countries are anticipated to restrain the global market. Moreover, adverse effects associated with triptans therapy and contraindication of the drugs to be administered in patients with cardiovascular complications are the other restraints of the global triptans market.
The global triptans market can be segmented based on product type, route of administration, distribution channel, and region. In terms of product type, the market can be categorized into amlotriptan, electriptan, frovtriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan. Based on route of administration, the global triptans market can be classified into injectable, oral, and others (nasal sprays and transdermal patches). The oral segment is anticipated to dominate the global triptans market because of low cost and easy availability of orally administrable drugs. In terms of distribution channel, the market can be divided into hospital pharmacies, retail pharmacies, and online pharmacies. The hospital pharmacies segment is expected to dominate the global market during the forecast period.
Geographically, North America is projected to dominate the global triptans market owing to high incidence of migraine. According to the American Migraine Prevalence and Prevention Study, about 12% of the people in the U.S. suffers from migraine. Europe held the second largest market share in 2017. The market in Asia Pacific is likely to expand at the highest CAGR during the forecast period attributed to developing economy and rise in prevalence of migraine.
Key players operating in the global triptans market include Valeant Pharmaceutical International, Inc., Allergan plc, Teva Pharmaceutical Industries Ltd., AstraZeneca plc, GlaxoSmithKline plc, Pfizer, Inc., Eli Lilly and Company, Novartis AG, Merck & Co., Inc., Janssen Pharmaceutical Company (Johnson & Johnson), Endo Pharmaceuticals, Inc., Zosano Pharma Corporation, Alder BioPharmaceuticals, Inc., Avanir Pharmaceuticals, Inc., and Eisai Co., Ltd.
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