Transdermal drug delivery is gathering steam as an advanced drug delivery method, especially for administering macromolecules. Several advantages they have over parenteral routes account for the growing popularity of products in the transdermal drug delivery market. Clinicians aiming at improving the pharmacokinetic profiles of drugs find this delivery route a fit, in addition to non-invasiveness of the methodology. This aside, the market is seeing investment by pharmaceutical companies who see potential of the method in improving the patient compliance. A large avenue comes from vaccine manufacturers.
Epidermal layers prove to be clinically unique in paving way to an efficient vaccination route for administering therapeutic proteins and peptides. The scope is considerably expanded by the drive among healthcare providers and governments, especially in the developing world, to find cost-effective and needle-free options for vaccination process. The large surface of the skin presents itself to incredible scope for utilizing transdermal drug delivery methods. A growing body of research has continuously expanded scientists’ understanding of kinetics of skin permeation, expanding the horizon for players in the transdermal drug delivery market. The kinetics pertains to percutaneous absorption of the drug molecules. Advent of promising physical and chemical methods is expanding the potential of transdermal patches for drug delivery.
Transdermal drug delivery is a mode of drug administration in which drug is administered through patient’s skin. The drugs or medicine that needs to be administered to a patient are usually applied in the form of a plaster, patch, or ointment in this administration route such that the drugs are gradually absorbed into the systemic circulation. Transdermal drug delivery systems (TDDS) are generally comprised of five key components: the drug, polymer matrix, permeation enhancers, adhesives, and backing layers. Transdermal drug delivery system has several advantages such as:
- The delivery of drug is non-invasive which is very less painful to the patient as compared to other forms of drug administration
- Avoids first-pass metabolism thus increasing the bio-availability of drug
- Transdermal drug delivery have fewer side effects than oral medications or supplements
- Administration of complete dose of the drug is possible through TDDS
- Provides controlled plasma levels of very potent drugs
- Termination of therapy is easy at any point of time
- Reduction in healthcare costs due to higher compliance & more effective treatment
Factors that directly affect the quality, permeation and efficacy of transdermal drug delivery include morphology and physiology of skin and the combination of skin, penetrant and delivery system.
The transdermal drug delivery market is driven by the introduction of easy-to-use and effective transdermal drug delivery systems based on cutting-edge technology. The transdermal drug delivery market is increasing due to its rising demand as it is more convenient than conventional systems for administrating drugs. For example, patients that are fanatical to oral drug dosages or those patients in unconscious state can be administered drugs through the transdermal route.
Transdermal patches provides improved control over toxicity levels as these patches can be easily peeled off if the drug is scrutinized to render higher toxic effects. Drug permeation can be monitored and estimated more effectively through this method, which makes it convenient to maintain a constant level of drug serum. In view of these factors, the adoption rate of products in the global transdermal drug delivery market is high. By application, the global transdermal drug delivery market can be classified as hormone replacement therapy, pain management, contraception, neurological disorders, and smoking cessation. Transdermal drug delivery system is one of the fastest growing segments of the total drug delivery sector as it is the most convenient drug delivery system.
Geographically, the global transdermal drug delivery market is segmented into North America, Europe, Asia Pacific and Rest of the World. Nicotine patch is highly sold in the United States. This patch releases nicotine in controlled manner to help with the cessation of tobacco smoking. In Europe, the first commercially available vapour patch was approved in 2007 to reduce smoking habits. Transdermal patches are gaining share in the global transdermal drug delivery market penetration because primary care physicians and patients equally put more emphasis on easy to use drug delivery methods.
Some of the key global participants present in the transdermal drug delivery market include 3M Pharmaceuticals Inc., Actelion Pharmaceuticals Ltd, Bayer Crop Science Ltd., BioGel Technology Inc., Upsher-Smith Laboratories, Inc., Johnson & Johnson Limited, Mylan Pharmaceuticals Inc., GlaxoSmithKline plc, Novartis AG, Janssen Pharmaceuticals, Inc., Noven Pharmaceuticals, Inc., Boehringer Ingelheim GmbH and Actavis Inc.