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Tardive dyskinesia (TD) is a disorder caused by a prolonged use of antipsychotic drugs by patients suffering from schizophrenia and other neuroleptic disorders. It is characterized by involuntary and uncontrolled movements of body parts such as eyeballs, lips, and tongue. Although tardive dyskinesia commonly occurs in patients who have been treated with antipsychotic medication for long periods, it also occurs occasionally in other conditions such as fetal alcohol syndrome, developmental disabilities, and other brain disorders, even after receiving 1 dose of causative agent. However, there are new atypical antipsychotic agents, such as olanzapine and risperidone, which have lesser risk of developing tardive dyskinesia. The disorder is linked with polymorphism of dopamine receptor gene types. The commonly used antipsychotic agents that are associated with tardive dyskinesia are chlorpromazine (Thorazine), fluphenazine (Prolixin), haloperidol (Haldol), thioridazine (Mellaril), and trifluoperazine (Stelazine). The risk of developing tardive dyskinesia is higher in older patients, women, and African & African-American population receiving antipsychotic treatment. It is estimated that approximately 500,000 people in the U.S. are affected by tardive dyskinesia each year. Increasing incidences of schizophrenia, growing bipolar disorder patients, and increasing antipsychotic prescriptions are driving the tardive dyskinesia treatment market. However, side effects of drugs, lack of awareness about the disorder and its medication, and undiagnosed cases are restricting the market growth.

The global tardive dyskinesia treatment market can be segmented based on type of disorder, drug class, and region. Based on the type of disorder, the market can be segmented as bradykinesias and hyperkinesias. Bradykinesias involves slowing of motion and difficulty in starting any action whereas hyperkinesias is characterized by akathisia, chorea, dystonia, myoclonus, stereotypy, tic, and tremor. Based on drug class, the market is segmented as dopamine-depleting medications (e.g., tetrabenazine, reserpine, and amantadine), GABA receptor agonist medications (e.g., clonazepam, baclofen, and valproic acid), and anticholinergic medications (e.g., trihexyphenidyl). In 2017, the FDA approved valbenazine (Ingrezza) for the treatment of adults with tardive dyskinesia. Ingrezza is manufactured by Neurocrine Biosciences, Inc, which is the first approved therapy for the treatment of the disorder. In addition, a variety of medicines are used for the treatment of tardive dyskinesia such as clonidine; however, dose limiting hypotension and sedation are its restraining factors. Botox injections are tried for minor dystonia. Vitamin B6, vitamin E, and branched chain amino acids are reported to be helpful to minimize the symptoms of the disorder. Benzodiazepine (clonazepam) is an effective therapy for tardive dyskinesia, however the development of tolerance is limiting its market growth. TEVA’s Austedo was approved for the treatment of chorea associated with Huntington’s disease; however, it is also filed for the new indication, which is for the treatment of tardive dyskinesia. Austedo is likely to create competition for Neurocrine Biosciences' Ingrezza.

Geographically, the tardive dyskinesia treatment market is distributed over North America, Europe, Latin America, Asia Pacific, and Middle East & Africa. North America is leading the market due to high prevalence of schizophrenia, increasing health awareness, and growing research and development investment.  Middle East & Africa is the second largest market after the U.S., followed by Europe. The market in Asia Pacific is expected to grow with a decent pace during the forecast period due to increasing health awareness and growing number of schizophrenic, bipolar, and other neuroleptic disorder patients.   

Key players operating in this market are Neurocrine Biosciences, Teva Pharmaceutical Industries, Valeant Pharmaceuticals, Sterimax Inc, Sun Pharma Global FZE, Pharmascience Inc., Eon Labs, Inc., Novopharm Limited, Novartis, and Oceanside Pharmaceuticals.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Tardive Dyskinesia Treatment Market