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Dilated Cardiomyopathy Therapeutics Market

Dilated Cardiomyopathy Therapeutics Market [Drug Class: Aldosterone Antagonists, Angiotensin-Converting Enzyme (ACE) Inhibitors, Angiotensin II Receptor Blockers (ARBs) and Beta-Blockers] - Global Industry Analysis, Pipeline Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020

 
Dilated cardiomyopathy (DCM) is a significant cause of heart failure and a leading indication for heart transplant among children and adults across the globe. This condition is characterized by enlargement of ventricular chamber, thinning of heart walls and inability to sufficiently pump blood throughout the body. Dilated cardiomyopathy can develop at any age but is more common among people aged between 20 years to 60 years. Genetic inheritance is found to affect about 30% to 40% of the total DCM patients. Single gene mutations in either the structural proteins of the myocyte, such as dystrophin, metavinculin, and lamin, or of mitochondrial DNA are also a prominent cause of DCM. Other factors such as diabetes, thyroid disorder, alcoholism, viral infections of the heart and heart valve abnormalities can also lead to dilated cardiomyopathy. Moreover, according to the Pediatric Cardiomyopathy Registry, DCM occurs at a rate of 6 per million children. It is commonly diagnosed in younger children with an average age of diagnosis at 2 years. 
 
The global dilated cardiomyopathy therapeutics market is studied from two perspectives i.e. by drug class and by geography. Till date, there is no FDA approved drug specifically for dilated cardiomyopathy treatment. Owing to the aforementioned fact, the drug classes used in treatment of dilated cardiomyopathy are essentially the same as that for treatment of congestive heart failure. Some of the widely prescribed drug classes in dilated cardiomyopathy treatment encompass aldosterone antagonists, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs) and beta blockers. Angiotensin II receptor blockers acquired the largest market share by revenue in 2013, followed by beta blockers. This is attributed to high demand for block buster drugs in dilated cardiomyopathy treatment especially in the developed regions such as North America and Europe. Aldosterone antagonists recorded high growth rate due to the identified positive impact of aldosterone antagonists when used in combination with either ARBs or ACE inhibitors in reducing the progression of Duchenne muscular dystrophy (DMD). Approval for this indication would further accelerate the overall sales of aldosterone antagonists, which in turn would positively impact market growth. 
 
Rising incidences of congestive heart failure across the globe is a prominent growth driver for dilated cardiomyopathy therapeutics market as DCM is one of the leading causes of heart failure. Globally, dilated cardiomyopathy accounts for approximately 30% to 40% of the total congestive heart failure cases each year. Owing to the alarming rise in incidences of congestive heart failure, several companies have initiated clinical trial studies to develop therapeutics specifically for dilated cardiomyopathy. For instance, Array BioPharma in 2015 is conducting a phase II study for its drug candidate ARRY-371797 for DCM treatment. Additionally, Celladon Corporation in 2014 completed its phase II study of MYDICAR for dilated cardiomyopathy treatment. Success of these clinical studies will boost the growth and demand for dilated cardiomyopathy therapeutics market in forthcoming years. However, promising gene therapy and availability of implantable devices (implantable cardioverter defibrillators (ICDs), heart pumps and pacemakers) are major restraints to the DCM therapeutics market. 
 
Geographically, dilated cardiomyopathy therapeutics market is studied for four regions: North America, Europe, Asia Pacific and the Rest of the World. In terms of revenue, North America accounted for the largest market share in 2013 owing to rising incidences of congestive heart failure and high acceptance of branded drugs. In the U.S., DCM is prevalent in approximately five to eight people out of every 100,000 people. In Canada, heart failure affects over 1% of the total population and is responsible for about 9% of all the deaths. Asia Pacific and Rest of the World markets are the fastest growing markets due to rising economic standards, growing disposable income and high demand for generic drugs. Key players in the global DCM market include Array BioPharma, Inc., AstraZeneca plc, Celladon Corporation, GlaxoSmithKline plc, Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Novartis International AG, Pfizer, Inc., Sanofi S.A., Teva Pharmaceutical Industries Ltd., and Vericel Corporation.
     
    Chapter 1 Introduction
    1.1 Report Description
    1.2 Market Segmentation
    1.3 Research Methodology
         1.3.1 Secondary Research
         1.3.2 Primary Research
    1.4 List of Abbreviations
    1.5 Assumptions and Stipulations
     
    Chapter 2 Executive Summary
    2.1 Market Snapshot: Global Dilated Cardiomyopathy Therapeutics Market (2013 & 2020)
    2.2 Comparative Analysis: Global Dilated Cardiomyopathy Therapeutics Market Revenue, by Geography, 2013 & 2020 (Value %)
     
    Chapter 3 Global Dilated Cardiomyopathy Therapeutics Market Overview
    3.1 Market Definition and Overview
         3.1.1 Classification of Cardiomyopathies
         3.1.2 Market Drivers
    3.1.2.1 Increasing number of heart failure cases worldwide will lead to rise in demand for effective medications, thereby driving market growth
         3.1.3 Market Restraints
                 3.1.3.1 Side effects associated with DCM drugs could restrain market growth
                 3.1.3.2 Enhanced relief from use of devices without any side effects will restrain the dilated cardiomyopathy drugs market
         3.1.4 Promising gene and stem cell therapies for DCM treatment may hamper the DCM drugs market growth
         3.1.5 Market Opportunities
         3.1.7 Increasing genericization of DCM drugs
    3.2 Market Attractiveness Analysis: Global Dilated Cardiomyopathy Therapeutics Market, by Geography, 2013
    3.3 Epidemiology (Prevalence, Cause, Mortality Rate)
    3.4 Epidemiology Studies on Dilated Cardiomyopathy
    3.5 Causes and Mortality
    3.6 Event Impact Analysis
    3.7 Competitive Landscape, by Key Players, 2013 (Value %)
         3.7.1 Market share by key players, 2013 (Value %)
     
    Chapter 4 Global Dilated Cardiomyopathy Therapeutics Market, by Drug Class
    4.1 Introduction
         4.1.1 Global Dilated Cardiomyopathy Therapeutics Market Revenue, by Drug Class 2012 – 2020 (USD Million)
    4.2 Aldosterone Antagonists
         4.2.1 Global Aldosterone Antagonists Market Revenue, 2012 - 2020 (USD Million)
    4.3 Angiotensin-Converting Enzymes (ACE) Inhibitors
         4.3.1 Global Angiotensin-Converting Enzyme (ACE) Inhibitors Market Revenue, 2012 - 2020 (USD Million)
    4.4 Angiotensin II Receptor Blocker (ARBs)
         4.4.1 Global Angiotensin II Receptor Blockers (ARBs) Market Revenue, 2012 - 2020 (USD Million)
    4.5 Beta-Blockers
         4.5.1 Global Beta-Blockers Market Revenue, 2012 - 2020 (USD Million)
     
    Chapter 5 Pipeline Analysis of Global Dilated Cardiomyopathy Therapeutics Market
    5.1 Pipeline Analysis
         5.1.1 Pipeline Analysis : Dilated Cardiomyopathy Therapeutics Market
     
    Chapter 6 Global Dilated Cardiomyopathy Therapeutics Market, by Geography
    6.1 Introduction
         6.1.1 Global Dilated Cardiomyopathy Therapeutics Market Revenue, by Geography, 2012 - 2020 (USD Million)
    6.2 North America
         6.2.1 North America Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)
    6.3 Europe
         6.3.1 Europe Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)
    6.4 Asia Pacific
         6.4.1 Asia Pacific Dilated Cardiomyopathy Therapeutics market Revenue, 2012 - 2020 (USD Million)
    6.5 Rest of the World (RoW)
         6.5.1 Rest of the World Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)
     
    Chapter 7 Recommendations
    7.1 Dilated phase of hypertrophic cardiomyopathy
    7.2 Genetic Intervention
     
    Chapter 8 Company Profiles
    8.1 Array BioPharma, Inc.
         8.1.1 Company Overview
         8.1.2 Financial Overview
         8.1.3 Product Portfolio
         8.1.4 Business Strategies
         8.1.5 Recent Developments
    8.2 AstraZeneca plc
         8.2.1 Company Overview
         8.2.2 Financial Overview
         8.2.3 Product Portfolio
         8.2.4 Business Strategies
         8.2.5 Recent Developments
    8.3 Celladon Corporation
         8.3.1 Company Overview
         8.3.2 Financial Overview
         8.3.3 Product Portfolio
         8.3.4 Business Strategies
         8.3.5 Recent Developments
    8.4 GlaxoSmithKline plc
         8.4.1 Company Overview
         8.4.2 Financial Overview
         8.4.3 Product Portfolio
         8.4.4 Business Strategies
         8.4.5 Recent Developments
    8.5 Janssen Pharmaceuticals, Inc.
         8.5.1 Company Overview
         8.5.2 Financial Overview
         8.5.3 Product Portfolio
         8.5.4 Business Strategies
         8.5.5 Recent Developments
    8.6 Merck & Co., Inc.
         8.6.1 Company Overview
         8.6.2 Financial Overview
         8.6.3 Product Portfolio
         8.6.4 Business Strategies
         8.6.5 Recent Developments
    8.7 Novartis International AG
         8.7.1 Company Overview
         8.7.2 Financial Overview
         8.7.3 Product Portfolio
         8.7.4 Business Strategies
         8.7.5 Recent Developments
    8.8 Pfizer, Inc.
         8.8.1 Company Overview
         8.8.2 Financial Overview
         8.8.3 Product Portfolio
         8.8.4 Business Strategies
         8.8.5 Recent Developments
    8.9 Sanofi S.A.
         8.9.1 Company Overview
         8.9.2 Financial Overview
         8.9.3 Product Portfolio
         8.9.4 Business Strategies
         8.9.5 Recent Developments
    8.10 Teva Pharmaceutical Industries Ltd.
         8.10.1 Company Overview
         8.10.2 Financial Overview
         8.10.3 Product Portfolio
         8.10.4 Business Strategies
         8.10.5 Recent Developments
    8.11 Vericel Corporation
         8.11.1 Company Overview
         8.11.2 Financial Overview
         8.11.3 Product Portfolio
         8.11.4 Business Strategies
         8.11.5 Recent Developments
    List of Tables
     
    TABLE 1 Market Snapshot: Global Dilated Cardiomyopathy Therapeutics Market (2013 & 2020)
    TABLE 2 Classification of Cardiomyopathies
    TABLE 3 Global Dilated Cardiomyopathy Therapeutics Market Revenue, by Drug Class, 2012 - 2020 (USD Million)
    TABLE 4 Pipeline Analysis : Dilated Cardiomyopathy Therapeutics Market
    TABLE 5 Global Dilated Cardiomyopathy Therapeutics Market Revenue, by Geography, 2012 - 2020 (USD Million)

     List of Figures

     

    FIG. 1 Dilated Cardiomyopathy Therapeutics Market: Market Segmentation

    FIG. 2 Global Dilated Cardiomyopathy Therapeutics Market, by Drug Class, 2013 (USD Million)

    FIG. 3 Comparative Analysis: Global Dilated Cardiomyopathy Therapeutics Market Revenue, by Geography, 2013 & 2020 (Value %)

    FIG. 4 Market Attractiveness Analysis: Global Dilated Cardiomyopathy Therapeutics Market, by Geography, 2013

    FIG. 5 Market Share Analysis: Global Dilated Cardiomyopathy Therapeutics Market, by Key Players, 2013 (Value %)

    FIG. 6 Global Aldosterone Antagonists Market Revenue, 2012 - 2020 (USD Million)

    FIG. 7 Global Angiotensin-Converting Enzyme (ACE) Inhibitors Market Revenue, 2012 - 2020 (USD Million)

    FIG. 8 Global Angiotensin II Receptor Blockers (ARBs) Market Revenue, 2012 - 2020 (USD Million)

    FIG. 9 Global Beta-Blockers Market Revenue, 2012 - 2020 (USD Million)

    FIG. 10 North America Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)

    FIG. 11 Europe Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)

    FIG. 12 Asia Pacific Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)

    FIG. 13 Rest of the World Dilated Cardiomyopathy Therapeutics Market Revenue, 2012 - 2020 (USD Million)

    FIG. 14 Array BioPharma, Inc.: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 15 AstraZeneca plc: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 16 GlaxoSmithKline plc: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 17 Johnson & Johnson (Pharmaceutical Division): Annual Revenue 2011 – 2013 (USD Million)

    FIG. 18 Merck & Co., Inc.: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 19 Novartis International AG: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 20 Pfizer, Inc.: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 21 Sanofi S.A.: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 22 Teva Pharmaceutical Industries Ltd.: Annual Revenue, 2012 – 2014 (USD Million)

    FIG. 23 Vericel Corporation: Annual Revenue, 2011 – 2013 (USD Million)

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Dilated Cardiomyopathy Therapeutics Market

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