Platelet-rich plasma (PRP) is a blood product having autologous property. It has a large number of platelets in a very minute quantity of plasma. The platelets which are 2 mm diameter in size are the cytoplasmic fragments of megakaryocytes developed in the marrow. More than 30 bioactive proteins are present in the platelets. These bioactive proteins are equipped with a vital role in tissue healing or hemostasis. Platelet-rich plasma have three main proteins - fibrin, fibronectin, and vitronectin in blood which have an important role in cell adhesion molecules.
Differential centrifugation is a process used for the preparation of platelet-rich plasma. Acceleration force in differential centrifugation is used to centrifuge the constituents present in the blood to settle on different specific gravity. Centrifugation is acquired at different relative centrifugal time, force, and temperature. The two-step procedure yields the highest result.
Platelet-rich plasma functions as a fibrin tissue adhesive for hemostatic and tissue covering effects. It is not similar to fibrin glue or platelet-poor tissue adhesives as the platelets have an ability to heal wounds and nourish osteogenesis. Biological isolation of platelet-rich plasma from whole blood is obtained for enriched platelets. Tissue regeneration, inflammatory response, promotion of angiogenesis, and infection controlling are improved with the help of high concentration of platelets in plasma.
Acceleration of endothelial, epithelial, and epidermal regeneration, stimulation angiogenesis, development collagen synthesis, promotion of soft tissue healing, reduction of dermal scarring, development of hemostatic response to injuries, and adverse inhibition of wound healing caused by glucocorticoids are all processed by platelet-rich plasma. The higher the leukocyte concentration in platelet-rich plasma, the higher the antimicrobial effect. Platelet-rich plasma does not carry any risk of transmitting infectious disease.
Concentrated bone marrow aspirate (BMA) is obtained from a patient’s own bone marrow. Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) are very high in concentrated bone marrow aspirate. Bone marrow aspiration concentrate (BMAC) has a great effect on osseous and cartilage defect healing as it contains stem cells and multiple growth factors. Mesenchymal stem cells and bone marrow aspirates concentrates from bone marrow are used in development of rotator cuff tears and for the repair of damaged structures in clinical and preclinical studies as they are a good cell source. However, absence of these factors in sufficient amount may lead to rotator cuff tears. Presence of these concentrates in adequate amount is important in stem cell-mediated repair of tears, including rotator cuff tears. Marrow is an abundant source of “pluripotent” stem cells. It is extracted from the patient’s pelvis and processed. When an injury takes place, a number of regenerative cells are required for tissue regeneration. If regenerative cells are inadequate in the body due to blood loss or any other reason, it might hamper the process. Stem cells are undifferentiated; they replicate themselves as different types of tissues as needed. The concentrate of regenerative cells in bone marrow concentrate provides strong and healthy healing of the damaged tissue, allowing it to grow and repair by exceeding the body’s natural healing process. Bone marrow concentrate also relieves pain, reduces swelling, and boosts healing of articular cartilage and bone.
Bone marrow aspirate concentrate is a cost-effective method in delivering mesenchymal stem cells, helping in the repair and regeneration of cartilage defects. This is expected to drive the growth of the platelet-rich plasma and bone marrow aspirate concentrate systems market during the forecast period. Platelet-rich plasma provides immediate surgical hemostatic agent which is safe, biocompatible, and effective. The strong differences in platelet and growth factor concentrations among other blood products might affect the cell viability or gene expression. Platelet-rich plasma from male and female donors is expected to have significant differences in growth factor content between male and female platelet-rich plasma. This is anticipated to restrain the growth of the platelet-rich plasma and bone marrow aspirate concentrate systems market in the near future.
The global platelet-rich plasma and bone marrow aspirate concentrate systems market can be segmented based on type, origin, severity, and region. Based on type, the platelet-rich plasma and bone marrow aspirate concentrate systems market can be divided into pure platelet-rich plasma, Leucocyte and platelet-rich plasma, pure platelet-rich fibrin, Leucocyte and platelet-rich fibrin, and the bone marrow aspirate concentrate systems. In terms of origin, the platelet-rich plasma and bone marrow aspirate concentrate systems market can be categorized into allogeneic platelet-rich plasma, autologous platelet-rich plasma, homologous platelet-rich plasma, and bone marrow. Based on severity, the global platelet-rich plasma and bone marrow aspirate concentrate systems market can be bifurcated into orthopedic surgery, cosmetic surgery, and general surgery. The cost effective process of platelet extraction which has rich content of stem cells & leukocytes, and high efficiency to treat diseases such as tendons & ligament injuries and neurological diseases are the other factors fueling the growth of the Leucocyte and platelet-rich fibrin segment
Geographically, the global platelet-rich plasma and bone marrow aspirate concentrate systems market can be segmented into North America, Latin America, Europe, Middle East & Africa, and Asia Pacific. North America accounted for the leading share of the market in 2017, and is expected to retain its dominance on the platelet-rich plasma and bone marrow aspirate concentrate systems market during the forecast period.
Prominent players operating in the global platelet-rich plasma and bone marrow aspirate concentrate systems market are Zimmer Biomet Holdings, Inc., EmCyte Corporation, Cesca Therapeutics, AdiStem Ltd., ISTO Biologics, Inc., Stryker Corporation, Arthrex, Inc., Harvest Technologies Corp. (Terumo Corporation), DePuy Synthes, Regen Lab SA, Exactech, Inc., and Nuo Therapeutics, Inc.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
With a robust experience in creating exceptional market reports, Transparency Market Research has emerged as one of the trusted market research companies among a large number of stakeholders and CXOs. Every report at Transparency Market Research goes through rigorous research activity in every aspect. The researchers at TMR keep a close watch on the market and extract beneficial growth-boosting points. These points help the stakeholders to strategize their business plans accordingly.
TMR researchers conduct exhaustive qualitative and quantitative research. This research involves taking inputs from the experts in the market, focused attention on recent developments, and others. This method of research makes TMR stand out from other market research firms.
Here's how Transparency Market Research helps the stakeholders and CXOs through the reports:
Inculcation and Evaluation of Strategic Collaborations: The TMR researchers analyze recent strategic activities like mergers, acquisitions, partnerships, collaborations, and joint ventures. All the information is compiled and included in the report.
Perfect Market Size Estimations: The report analyzes the demographics, growth potential, and capability of the market through the forecast period. This factor leads to the estimation of the market size and also provides an outline about how the market will retrieve growth during the assessment period.
Investment Research: The report focuses on the ongoing and upcoming investment opportunities across a particular market. These developments make the stakeholders aware of the current investment scenario across the market.
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.