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Pigmented villonodular synovitis (PVNS) is a rare benign proliferative (overgrowth) form that affects the synovial membrane (also termed as stratum synoviale or synovium). Synovial membrane is a thin sheet of connective tissue that lines the inner surface of capsules of tendon sheath and synovial joints. The cell bulk or lump that results from overgrowth is not carcinogenic and does not spread to other parts of the body by metastasis. PVNS is a progressive disease that gradually becomes worse and can lead to arthritis and damage the bones. PVNS is mostly monoarticular (affects only one joint of the body or affects around 70% part of knee joint), but it can also be oligoarticular (affecting a few joints). The histology of PVNS are similar to some violent neoplasms (epithelioid sarcoma, synovial sarcoma, and rhabdomyosarcoma), therefore, has an important role in managing the pathologist. Radiographs show general characteristics such as bone erosions and joint effusion. Ultrasound and CT scan can also show the hypertrophic synovium as a slightly echogenic/hyper dense soft tissue bulk. MRI is the best method that shows the mass like synovial propagation with lobulated margins, with small signal intensity and “blooming” structure on gradient echo. These gradient echoes are due to deposition of hemosiderin (an iron-storage complex).

Mostly PVNS occurs in persons with starting of mid age. There is no gender predilection for intra articular disease, whereas extra articular disease has a minor female predominance. Symptoms in PVNS include joint dysfunction, pain, and sometimes joint inflammation. Mostly, symptoms have been exist for several months before the analysis is done. It is rare among children; however, it occasionally occurs and is more often polyarticular. It can also been defined in relation with: vascular lesions, Noonan syndrome, multiple lentigines syndrome, mandibular lesions, extremity lymphedema, and cherubism. Treatment includes surgery to eliminate the tumor (lumps) and the injured parts of the joint lining. When local PVNS has also injured a tendon, doctor will repair it by removing the tumor.

Rise in concerns and awareness related to health and increased prevalence of the disease are the major factors fueling the growth of the pigmented villonodular synovitis treatment market. Moreover, availability of advanced medications and surgical procedures are the other factors driving the market. However, unawareness about disease and less availability of advanced resources and medical facilities in underdeveloped countries restrain the market.

The global pigmented villonodular synovitis treatment market can be segmented based on type of treatment, end-user, and region. In terms of type of treatment, the market can be classified into drug therapy, radiation therapy, and surgical operation. The drug therapy segment can be sub-segmented into cabiralizumab, emactuzumab, mcs-110, nilotinib, and others. The surgical operation segment can be divided into arthroscopy, open surgery, combined arthroscopic and open surgery, and total joint replacement. Based on end-user, the global villonodular synovitis treatment market can be categorized into hospitals, surgical clinics, and others.

In terms of region, the global pigmented villonodular synovitis treatment market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is expected to dominate the global pigmented villonodular synovitis treatment market due to availability of advanced surgical procedures, medications, and other therapies such as radiation therapy. Awareness among the people about the diseases is another factor boosting the market in this region. The pigmented villonodular synovitis treatment market in Asia Pacific is anticipated to expand at a high growth rate due to increase in prevalence of the disease.

Key players operating in the global pigmented villonodular synovitis treatment market are Plexxikon, Inc., Novartis AG, F. Hoffmann-La Roche Ltd., and Bristol-Myers Squibb Company, among others.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Pigmented Villonodular Synovitis Treatment Market

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