The process of chaining or modification of biological molecules by conjugation with non-immunogenic polymer and nontoxic polyethylene glycol to improve or modify the physicochemical property of molecule is known as PEGylation. PEGylation improves stability and solubility of drug and decreases immunogenicity by changing the electrostatic binding, confirmation, and hydrophobicity of the molecule. PEGylation decreases the dose frequency by reducing renal excretion and proteolysis, and increases tension time of conjugates in blood and stability of drug. A variety of therapeutic peptides, proteins, and small drug molecules have been PEGylated to improve or alter pharmacokinetic parameters in order to benefit from various consequences.

The controlled releasable PEGs have been aimed to avoid any loss of efficacy by controlling the release of native protein from the conjugates into the blood. PEGylation of therapeutic proteins has enhanced the management of several chronic diseases, including cancer, leukemia, hepatitis C, rheumatoid arthritis, severe combined immunodeficiency disease, and Crohn’s disease. Pegaspargase, pegademase bovine, pegfilgrastim, certolizumab pegol, pegvisomant, pegaptanib, and interferons are the most important PEGylated drugs. Some of PEGylated products are in various development stages. The applications and rising adoption of PEGylation to treat various chronic diseases are likely to drive the PEGylated proteins market during the forecast period.

The PEGylated proteins market can be segmented based on product type, application, process, end-user, and region. In terms of product type, the market can be segmented into services and consumables. The services segment includes development, production, process developments, and feasibility study of PEGylate, and process of PEGylation. The consumables segment includes PEGylation kits and reagents.

In terms of application, the PEGylated proteins market can be segmented into hepatitis, hemophilia, cancer, multiple sclerosis, gastrointestinal disorder, and others. The others segment includes protein drug delivery and other diseases. Increasing prevalence of chronic diseases is likely to drive the PEGylated proteins market during the forecast period. PEGylated proteins increase the stability of drug in body and gives better action as compared with normal drug. Presently, PEGylation is used for chemotherapy due to its associated benefits.

Based on process, the market can be segmented into chemical PEGylation, enzymatic PEGylation, and genetic PEGylation. These are main techniques or processes used in preparation of PEGylated proteins. End-users of PEGylated proteins are pharmaceutical & biotechnology companies, contract research organizations, and academic research institutes. The pharmaceutical and biotechnology companies segment is expected to witness fastest growth during the forecast period led by increasing R&D spending in pharmaceutical and biotechnology sectors globally.

In terms of region, the PEGylated proteins market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America and Europe dominate the PEGylated proteins market. Countries in these regions are well developed and patients are highly aware about the disease and available therapies. Asia Pacific is most progressive market for PEGylated proteins. Increasing prevalence of lifestyle diseases in the region, rising health care spending, and growing medical tourism are expected to drive the market in Asia Pacific.

Rising adoption of protein based drugs over non-protein based drugs is the key factor likely to drive the PEGylated proteins market during the forecast period. PEGylated proteins have wide applications and advantages over traditional therapy, and hence the adoption is high. Other factors such as increasing research and development funding by governments of different countries, growth of biological sector, and increasing protein stability and solubility are attributed to the growth of the PEGylated proteins market. Factors such as failure of drug development and recall of products are expected to hamper the PEGylated proteins market during the forecast period.

Major players in the PEGylated proteins market are Merck Millipore, Thermo Fisher Scientific, Inc., JenKem Technology, Celares GmbH, Biomatrik, Inc., Laysan Bio, Inc., Laysan Bio, Inc., and Creative PEGWorks.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

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The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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