Global Opioid Tolerance Treatment – Overview:

Opioid treatment is massively noted in severe pain management and chronic cancer treatment. One of the reasons behind their extensive use is high efficacy. However, there are negative implication sometimes noted when these are used for a longer time. The effect in therapy reduces, and response to therapy becomes dull. Such patients require either higher doses or NMDA antagonists. Alpha2-adrenoceptor agonists are also put to work sometimes.

As per a comprehensive analysis by Transparency Market Research, the market for opioid tolerance treatment will record moderate growth in the market, expanding the opportunities landscape for market players. Valuation of the market would also see growth in the period 2019 to 2027 – the assessment period of the growth.

Some of the prominent factors leading to growth in the market are outlined below. These are molding the future of the market in a major way.

  • Drug abuse is gaining a firm foothold across countries and communities. Some of the regions that are facing a menace in terms of opium use are the countries falling in proximity to the Golden Crescent and the Golden Triangle – regions known for illicit opium production in the Asia Pacific region. Authorities and medical community is trying to fight this through research and development, and development of better therapeutics, paving way for growth in the market.
  • A robust pipeline exists in the market for tolerance treatment and a number of clinical trials are underway. This ensures growth for the global opioid tolerance treatment market over the forecast period. The use in healthcare will be a major factor of growth.

Global Opioid Tolerance Treatment Market - Snapshot

Opioids are effective analgesics prescribed to people with chronic cancer and severe pain. These opioids are generally used for short period of time. If these opioids are prescribed or taken for a longer period of time or more frequent daily doses, they create opioid tolerance in patients and hence, analgesia or desired therapeutic response is not received. In such conditions, higher doses of opioids are required to treating patients.

Opioid tolerant patients can be treated with other treatment options for opioid tolerance such as NMDA antagonists and alpha2-adrenoceptor agonists. These drugs provide the required therapeutic response to opioid tolerant patients or to treat opioid tolerance.

  • The global opioid tolerance treatment market was valued at around US $1,500 Mn in 2018. It is anticipated to expand at a CAGR of around 3.5% from 2019 to 2027. The alpha2-adrenoceptor agonists segment dominates the global opioid tolerance treatment market in terms of value and is expected to continue this trend during the forecast period.
  • The opioid tolerance treatment market is expanding at a significant pace due to rise in consumption of opioids for medical & non-medical purposes and rise in number of opioid prescriptions for therapeutic purpose, which leads opioid tolerance if taken for a long duration of time.
  • Additionally, ongoing clinical trials, various researches going on for opioid tolerant treatment by different research institutes & companies and growing drug abuse, drug overdose cases are some of the major factors responsible for the growth of opioid tolerance treatment market. 

The opioid tolerance treatment market has been segmented based on drug, type of opioid tolerance, route of administration, end-user, and region.

  • On the basis of drug, the global opioid tolerance treatment market has been divided into NMDA antagonists, alpha2-adrenoceptor agonists, and others.
  • The NMDA antagonists segment has been sub-segmented into ketamine, dextromethorphan, and others. The alpha2-adrenoceptor agonists segment is sub-divided into clonidine, tizanidine, and others.
  • The alpha2-adrenoceptor agonists segment dominated the global opioid tolerance treatment market during the forecast period and is expected to continue this trend during the forecast period owing to relatively fewer side effects and better efficacy to treat opioid tolerance.
  • Based on type of opioid tolerance, the global opioid tolerance treatment market has been bifurcated into innate tolerance and acquired tolerance. The acquired tolerance segment dominated the global opioid tolerance treatment market in 2018. The segment is anticipated to expand at a considerable CAGR during the forecast period owing to increase of drug dose & quantity and long term use of opioids.
  • In terms of route of administration, the global opioid tolerance treatment market has been categorized into enteral, parenteral, and others. The parenteral segment dominated the global opioid tolerance treatment market. Faster onset of action and high bioavailability are some factors driving this segment.
  • Based on end-user, the global opioid tolerance treatment market has been classified into hospitals & ASCs, rehabilitation centers, and others. The hospitals & ASCs segment dominated the global opioid tolerance treatment market due to higher number of patient admissions for cancer, chronic pain and better facilities available at these settings. 
opioid tolerance treatment market

In terms of region, the global opioid tolerance treatment market has been split into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.

  • North America dominated the global opioid tolerance treatment market in 2018 due to higher number of opioid prescriptions dispensed, high opioid consumptions, and well-established health care infrastructure in the region.
  • The opioid tolerance treatment market in Asia Pacific is expanding at a considerable CAGR during the forecast period due to large cancer patient pool, increase in health care expenditure, and high opioid consumption in the region. 

Key players operating in the global opioid tolerance treatment market include

  • Boehringer Ingelheim International GmbH
  • GlaxoSmithKline plc.
  • Teva Pharmaceutical Industries Ltd.
  • Mylan N.V.
  • Otsuka Pharmaceutical Co. Ltd.
  • Johnson & Johnson Services
  • Aurobindo Pharma
  • Pfizer Inc.
  • Acorda Therapeutics, Inc.
  • Zydus Cadila

Global Opioid Tolerance Treatment Market: Overview

The global opioid tolerance treatment market report comprises an elaborate executive summary, which includes a snapshot that provides information about various segments of the market. It also provides information and data analysis of the global market with respect to the segments based on drug, type of opioid tolerance, route of administration, end-user, and region.

A detailed qualitative analysis of drivers and restraints of the market and opportunities has been provided in the overview section. Additionally, the section comprises a competitive matrix and company profiles along with business overview to understand the competitive landscape in the market. This section of the report also provides market attractiveness analysis by region, thereby presenting a thorough analysis of the overall competitive scenario in the global opioid tolerance treatment market.

Global Opioid Tolerance Treatment Market: Key Segments

  • The opioid tolerance treatment market has been categorized based on drug, type of opioid tolerance, route of administration, end-user, and region.
  • In terms of drug, the global market has been segregated into NMDA antagonists, alph2-adrenoceptor agonists, and others. The NMDA antagonists segment has been sub-segmented into ketamine, dextromethorphan, and others. Similarly, the alpha2-adrenoceptor agonists segment has been divided into clonidine, tizanidine, and others.
  • In terms of type of opioid tolerance, the global opioid tolerance treatment market has been bifurcated into innate tolerance and acquired tolerance.
  • Based on route of administration, the global market has been segmented into enteral, parenteral, and others.
  • In terms of end-user, the global opioid tolerance treatment market has been classified into hospitals & Ambulatory surgery centers, rehabilitation centers, and others.
  • Each of the segments has been analyzed in detail for market trends, recent trends & developments, drivers, restraints, opportunities, and useful insights. The report provides current and future market size for each segment and sub-segments for the period from 2017 to 2027 in terms of revenue valued in US $ Mn, considering 2018 as the base year. The compound annual growth rate has been provided for each segment and market for the period of 2019 to 2027 with market size estimations. 

Global Opioid Tolerance Treatment Market: Regional Outlook

  • In terms of region, the global opioid tolerance treatment market has been split into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.
  • These regions have been further sub-divided into major countries and sub-regions. Current and future market sizes in terms of revenue (US$ Mn) of these regional markets and their major countries have been provided in the report for the period from 2017 to 2027, with their CAGR (%) for the period from 2019 to 2027. 

Companies Mentioned in Report

The global opioid tolerance treatment report concludes with the company profiles section that includes key information about the major players in the market. Key players identified in this report include

  • Boehringer Ingelheim International GmbH
  • GlaxoSmithKline plc.
  • Teva Pharmaceutical Industries Ltd.
  • Mylan N.V.
  • Otsuka Pharmaceutical Co. Ltd.
  • Johnson & Johnson Services
  • Aurobindo Pharma
  • Pfizer Inc.
  • Acorda Therapeutics, Inc.
  • Zydus Cadila 

Each of these players have been profiled in the report based on parameters such as company overview, financial overview, business strategies, product portfolio, business segments, and recent developments.

The global opioid tolerance treatment market has been segmented as follows:

Drug

  • NMDA Antagonists
    • Ketamine
    • Dextromethorphan
    • Others (including Guaifenisin)
  • Alpha2-adrenoceptor Agonists
    • Clonidine
    • Tizanidne
    • Others(including Lofexidine)
  • Others (including Endothelin Receptor Antagonists, NSAIDs, Opioid Combinations, and Multimodal Pain Management Drugs)

Opioid Tolerance

  • Innate Tolerance
  • Acquired Tolerance

Route of Administration

  • Enteral
  • Parenteral
  • Others (including Transdermal Route, Patches, and Cartons of Patches) 

End-user

  • Hospitals & ASCs
  • Rehabilitation Centers
  • Others (including Home Care Settings and Research Institutes) 

Region

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Rest of the Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

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