Oligonucleotide API Market: Overview

Pharmaceutical companies have harnessed oligonucleotide active pharmaceutical ingredients (APIs) popularly in solid solutions (powdered form) and recently in solution form. The drive for the oligonucleotide API market stems from the vast utilization of oligonucleotides in treating a wide range of diseases. The product devcamelopment has paved way to new therapeutic strategies in numerous therapies, notably in ophthalmologic indications, neuromuscular diseases, and as adjuvants for vaccine development.

Some of the key oligonucleotide classes are antisense oligonucleotides, micro-RNA, small/short interfering RNA, immunostimulatory oligonucleotides, splice-switching oligonucleotides, and aptamers. Some of the factors that have boosted the trend of oligonucleotide APIs in solution are solution stability, viscosity, concentration, end-to-end manufacturing, and packaging.

Progress made in industry associations sharing of CMC (chemistry, manufacturing, and control) strategies is boosting the prospect in the oligonucleotide APIs market. Growing demand for new drug classes for COPD (Chronic Obstructive Pulmonary Disease) and asthma has unlocked new avenues in the market.

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Oligonucleotide API Market: Key Trends

The growing percentage of oligonucleotide APIs in drug pipeline worldwide is a key factor underpinning the evolution of the market. Over the past 10 – 15 years, pharma companies have benefitted from the industry trend toward harmonization of oligonucleotide development and their commercialization. In this regard, the European Pharma Oligonucleotide Consortium (EPOC) has made concerted efforts with pharma companies around the world. A growing body of science-based recommendations has paved way to development of oligonucleotide therapeutics. Rise in research in biologic therapeutics has strengthened the drug pipeline of pharma companies in the oligonucleotide APIs market.

The market stakeholders have benefited from a comparative study on solution versus powder API. The several benefits associated with powder API produced by process of lyophilization has increased its preference. Several studies on preserving the stability of different classes of oligonucleotides have boosted the expansion of the oligonucleotide APIs market. Advances in methods aimed at concentration of the oligonucleotide API solution has led to gains to pharma companies. Further, the growing use of advanced chromatographic purification is boosting the oligonucleotide APIs market.

Antisense oligonucleotide (ASO) therapeutics have gained popularity in the expansion of the market. Key ones are Tegsedi, Waylivra, and Spinraza. In recent years, the increased focus on personalized medicine among various healthcare systems around the world has stimulated new avenues for stakeholders including industry players.

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Oligonucleotide API Market: Competitive Analysis and Key Developments

Research in utilizing oligonucleotides in infectious and genetic diseases has spurred new therapeutic strategies in the oligonucleotide APIs market. Several pharma companies over the past 10 years have rebuffed their efforts in utilizing the potential. To this end, they have been notably ramped up their investments in expanding their production capacities.

Corden Pharma GmbH, a German pharma company, has announced to make manufacturing capacity expansion in Colorado, U.S. The capacity expansion notably includes the synthesis and purification of the concentrate. The company has aimed at offering companies manufacturing services expanding their drug development programs in clinical trials.

As many as oligonucleotide programs are in development in 2019, moving from research through Phase III. This accounts for the vast investment potential for pharma companies in the oligonucleotide APIs market.

Some of the promising industry players in the oligonucleotide APIs market are Biogen, GE Healthcare Life Sciences, and Nitto Denko Avecia.

Oligonucleotide API Market: Regional Assessment

Expansion of commercially approved oligonucleotide therapeutics has attributed the rise in avenues in North America and Europe in the global APIs market. These regions have seen a few exciting paradigms in API manufacturing process taking place. Increasing focus on developing personalized medicine for cancer has also spurred product development in these geographies.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Oligonucleotide Api Market