NGS Sample Preparation Market Introduction

Next Generation Sequencing (NGS) is a genome analysis platform which is more affordable, rapid and accurate. NGS is built upon first generation sequencing technologies to generate accurate and cost-effective results of sequencing. Next generation sequencing is a powerful platform which has made it possible to simultaneously sequence thousands to millions of DNA molecules. This powerful tool is revolutionizing areas such as genetic diseases, personalized medicine, and clinical diagnostics by providing a high throughput option with the capability for sequencing multiple individuals at the same time.

All NSG platforms need a library which can be prepared by generating a collection of DNA fragments for the sequencing. NGS libraries are generally prepared by fragmenting a sample of genomic DNA and ligating both fragment ends with specialized adapters. These adapter sequences provide a universal priming site to sequence primers by allowing for library hybridization to the sequencing chips. An alternative process called tagmentation constitutes a combination of fragmentation and ligation reactions into a single step. These adapter-ligated fragments are later PCR amplified and gel purified. 

NGS Sample Preparation Market – Competition Landscape

Rise in adoption of genomics for developing innovative diagnostic tools and tests and development of precision & personalized medicines has led to surge in collaboration among NGS tools & service providers and diagnostic & pharmaceutical companies. For an instance, in June 2017, Bristol-Myers Squibb Company and QIAGEN entered into an agreement for development gene expression profiles (GEPs) using NGS technology for former’s immuno-oncology (I-O) therapies in cancer treatment. In 2017, Illumina partnered with China’s KingMed Diagnostics to use its NGS technology for oncology and genetic disease testing. 

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Illumina, Inc.:

The US based, Illumina, Inc. is a manufacturer and provider of life science solutions with focus on gene sequencing and analysis. It is one of the leading supplier for NGS sample preparation tools. Illumina, Inc. is pioneer in providing affordable NGS platforms for researchers.

Agilent Technologies, Inc.:

Company offers its NGS sample preparation solutions under its Diagnostics and Genomics Group. Agilent has adopted inorgcanic growth strategies to expand its NGS solutions portfolio, for an instance company has acquired Lasergen which was engaged in development of DNA sequencing technologies, in 2017, Agilent acquired molecular and sample barcoding patents from Population Genetics Technologies. In February 2019, Agilent Technologies launched its NGS library preparation systems designed specifically to run complex DNA sequencing assays. 

Other key players operating in the in the global NGS sample preparation market include Thermo Fisher Scientific, QIAGEN, BD, Pacific Biosciences of California, Inc., 10x Genomics, F. Hoffmann-La Roche Ltd., Oxford Nanopore Technologies, and Eurofins Scientific. These players have adopted strategies such as agreements, partnerships, new product development, and collaborations to gain competitive advantage in the global NGS sample preparation market. 

NGS Sample Preparation Market Dynamics

Increase in application of NGS in genomics and diagnostic research -

NGS tools manufacturers and service providing companies are collaborating on development of innovative and more precise diagnostic tools. Genetic testing is advancing its application in pre-diagnosis of various chronic and genetic diseases such as cancer, diabetes, certain neural disorders and others. As the demand for quality healthcare and preventive diagnostics is likely to surge it is anticipated to augment the use of NGS technique, thereby propelling the NGS sample preparation market. 

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Accurate, Rapid and Affordable Platforms for Gene Sequencing & Analysis -

NGS offers accurate and rapid gene sequencing and analysis for researchers. As the adoption for genetics in healthcare and other life sciences related industries is growing, more and more players are introducing their products and services for NGS sample preparation. With the surge in number of suppliers, the cost for NGS sample preparation is likely to decline. Further key players are striving to introduce more affordable and accurate NGS solutions. For an instance, in 2014 Agilent Technologies, Inc. launched its HiSeq X10 NGS platform which made NGS affordable to many researchers across the globe, its recent introduction of NovaSeq NGS platform is likely to revolutionize the NGS processes by further reducing the procedure costs.

Limited Availability in Emerging Markets & Lack of skilled operators hinders the market growth

Although costs related to NGS have reduced to an extent; however, it is not adopted across developing markets. Further lack of skilled workforce to operate and use advanced NGS tools and post sequencing analysis are likely to hamper the growth of the NGS sample preparation market in emerging markets such as Latin America, Asia Pacific and Middle East & Africa. 

NGS Sample Preparation Market Segmentation

Based on the product type, the NGS sample preparation market can be segmented into

  • Sequencer Systems
  • Consumables & Reagents

Based on the workflow, the NGS sample preparation market can be segmented into

  • Target Enrichment
  • Library preparation
  • Quality control

Based on the technology, the NGS sample preparation market can be segmented into

  • Ion semiconductor sequencing
  • Sequencing by synthesis (SBS)
  • Nanopore sequencing
  • Single-molecule real-time sequencing (SMRT)
  • Others

Based on the application, the NGS sample preparation market can be segmented into

  • Diagnostics
  • Drug discovery
  • Agricultural & animal research
  • Others

Based on the end-use industry, the NGS sample preparation market can be segmented into

  • Hospitals & Clinics
  • Pharmaceutical & Biotechnology Companies
  • Academic Institutes & Research Centers
  • Others 

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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