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Next-generation Immune Repertoire Sequencing Market: Introduction

  • Profiling of T- and B-cell receptor repertoires in an individual has led to a vast repository of information on acquired immunity against various microorganisms. Next-generation immune repertoire sequencing has allowed researchers to make sophisticated immuno-bioinformatics analyses. It has generated interest among the research community and biopharmaceutical industries in the clinical development of antibody engineering, vaccine design, and cellular immunotherapy. Rise in applications of nutritional and intestinal immunology drives the rapid evolution of next-generation immune repertoire sequencing. The innovative technology has provided unprecedented insights into host-microbiome immune homeostasis, and along with single-cell transcriptomics presents significant opportunities in the life sciences industries across the world.
  • Immune repertoire sequencing is utilized in biomarker discovery to enhance the success rate and cost-effectiveness of rational drug development. For instance, in November 2017, the Center for Commercialization of Cancer Immunotherapy (C3i) started offering T cell receptor-beta sequencing services in its Biomarker and Diagnostic unit in Canada. Rise in demand for personalized medicine is anticipated to support the immune repertoire sequencing market growth, as personalized medicine uses an individual’s genetic profile to guide decisions made with regard to the prevention, diagnosis, and treatment of diseases.

Key Drivers, Restraints, and Opportunities of Global Next-generation Immune Repertoire Sequencing Market

  • Rise in need of expanding the understanding of key processes in systems immunology is a key factor driving the demand for next-generation immune repertoire sequencing. Increase in applications of TCR repertoire sequencing in clinical settings is one of the key aspects in improving immune repertoire sequencing. Over the past several years, this has generated a groundswell of interest in this high-throughput sequencing in realms of nutritional and intestinal immunology. Its potential application in gaining insight into lymphocyte diversity has gained some traction, catalyzing the market’s growth. For example, next-generation immune repertoire sequencing has potential in detecting minimal residual disease in lymphoid malignancies post treatment. This helps in evaluating the effectiveness of vaccination.
  • Furthermore, increase in the role of next-generation immune repertoire sequencing for personalized immune modulation is a key trend in the global next-generation immune repertoire sequencing market. Rise in need of better anti-cancer treatment will galvanize research into immune therapy and vaccine development with the help of next-generation immune repertoire sequencing. New avenues in intestinal immunology will pave the way for new, exciting products in the market.

North America to Capture Major Share of Global Next-Generation Immune Repertoire Sequencing Market

Developed regions such as North America and Europe are expected to make significant progress and likely to account for substantial share of the global next-generation immune repertoire sequencing market in terms of revenue. The market in North America is driven by growing traction that immunotherapy has gained in the treatment of cancer and infectious diseases. Developments in Europe are expected to be driven by sizeable funding in biomedical research and rise in research in genomic and autoimmune disease.

North America is anticipated to dominate the global market during the forecast period due to the presence of key industry players in the region (including Thermo Fisher Scientific, Illumina Inc., Pacific Biosciences, and CD Genomics). These players are increasingly focusing on development of novel technologies for immune repertoire sequencing. For example, in 2017, 10x Genomics Inc., a U.S.-based company, added B-Cell and 5’Unbiased Enrichment Kit to its chromium immune repertoire profiling solution or immune repertoire sequencing.

The market in Europe is likely to grow at a rapid pace in the next few years. The market in the region is anticipated to gain momentum during the forecast period, due to increase in funding by the government bodies to assist international innovative projects and marketable innovative products, processes, and services, in order to cater to unmet medical needs. In July 2018, Eurostars (a joint program between EUREKA and the European Commission) granted US$ 495,000 to OSE Immunotherapeutic SA’s project titled: ‘Treatment Response Monitoring for Cancer Immunotherapies utilizing Immune Repertoire Analysis’.

 Key Players Operating in Global Next-generation Immune Repertoire Sequencing Market

The presence of several prominent players in developed regions has raised the intensity of competition in the global market in the past few years. These players make significant investments in research & development of immuno-bioinformatics analyses using next-generation immune repertoire sequencing.

Major players operating in the global next-generation immune repertoire sequencing market are:

  • Adaptive Biotechnologies
  • Atreca, Inc.
  • CD Genomics
  • Pacific Biosciences
  • Juno Therapeutics
  • Roche Holding AG
  • ArcherDX, Inc.
  • Illumina, Inc.
  • Abvitro (Now Juno Therapeutics)
  • Agilent Technologies
  • Bgi
  • Irepertoire, Inc.
  • Oxford Nanopore Technologies, Ltd.
  • Qiagen N.V.
  • Takara Bio, Inc.
  • Thermo Fisher Scientific
  • Others

Global Next-Generation Immune Repertoire Sequencing Market: Research Scope

Global Next-Generation Immune Repertoire Sequencing Market, by Product

  • Instrument
    • NGS
    • PCR
  • Assays, Kits, and Reagents
    • TCR Kits
      • Human TCR Kits
      • Mouse TCR Kits
    • BCR Kits
      • Human BCR Kits
      • Mouse BCR Kits
  • Analytical Software
    • TCR Analysis Solutions
    • BCR Analysis Solutions
    • TCR & BCR Analysis Solutions
  • Services
    • Pre-Sequencing Services
    • Sequencing Services
    • Data Analysis Services

Global Next-generation Immune Repertoire Sequencing Market, by Application

  • Biomarker Discovery
  • Autoimmune Diseases
  • Cancer Immunotherapy
  • Infectious Disease Research
  • Asthma and Allergy Research
  • Vaccine Development
  • Immunodeficiency Identification
  • Others

Global Next-generation Immune Repertoire Sequencing Market, by End-user

  • Diagnostic Labs
  • Pharmaceutical & Biotech Companies
  • Research Institutes
  • Others

Global Next-generation Immune Repertoire Sequencing Market, by Region

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

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The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

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Below is a snapshot of these quadrants.

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The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

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10. What will be the barrier to entry for new players in the market?

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Next Generation Immune Repertoire Sequencing Market