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Marfan syndrome is a genetic disorder that affects body’s connective tissues. Connective tissues are made up of proteins, especially fibrilin-1, which are responsible for holding the whole body, i.e. organs, tissues, and cells together. Marfan syndrome is caused by the mutation in FBN1 gene which makes protein fibrilin-1. A defect in the fibrilin protein can cause overgrowth in the bones. Moreover, Marfan syndrome primarily affects the cardiovascular system, skeletal system, skin, and the eyes of humans. The condition is mostly inherited; however, 25% of the time it is a new (de novo) mutation. According to the National Human Genome Research Institute, globally one in every 10,000 to 20,000 individuals develop Marfan syndrome. People with Marfan syndrome are very tall, with long, thin arms and legs, with spider like fingers, referred as arachnodactyly. Other symptoms include myopia, ectopia lentis, glaucoma, retinal detachment, and early cataract formation. Additionally, bone overgrowth, loose joints, curvature of the spine (scoliosis), mitral valve prolapse, aortic dissection, and tricuspid valve prolapse are also observed in affected individuals.

Marfan syndrome is difficult to diagnose because its signs and symptoms can vary from person to person. Diagnosis can be carried out through physical examination, medical history, eye examination, chest X-ray, MRI scan, genetic testing, prenatal testing, and preimplantation genetic testing. The Marfan syndrome cannot be cured, but patients can live long, full life with proper treatment and/or management. There is no medical treatment to reverse the fibrillin abnormality in people with Marfan syndrome. Medications that can decrease the pressure inside the aorta such as beta blockers and angiotensin blockers are mostly prescribed. Beta blockers such as propranolol, metoprolol, and atenolol decrease the strain on the aorta by reducing force of contraction. Angiotensin blockers act primarily by lowering blood pressure, which reduces the stress on artery walls.

Prevalence of Marfan syndrome is more common in infants as it is hereditary. Emergence of new technologies, favorable government initiatives, and availability of favorable reimbursement policies for high-cost therapies are projected to drive the global Marfan syndrome treatment market in the near future. However, high cost of drugs and availability of limited scientific data on the treatment and cure of Marfan syndrome are likely to restrain the global Marfan syndrome treatment market.

The global Marfan syndrome treatment market can be segmented based on treatment type, route of administration, distribution channel, and region. In terms of treatment type, the global market can be categorized into heart treatment such as aortic dilation, drugs treatment such as beta blocker, calcium channel blocker & ACE blocker, surgery, bone and joints treatment, eye treatment, and others. Based on route of administration, the global Marfan syndrome treatment market can be bifurcated into oral and injectable. In terms of distribution channel, the market can be divided into retail pharmacies, hospital pharmacies, and online pharmacies.

Geographically, the global Marfan syndrome treatment market can be segmented into North America, Europe, Latin America, Asia Pacific, and Middle East & Africa. North America is expected to account for the largest share of the global market due to high expenditure on health care and easy diagnosis and availability of drugs. Europe is expected to be the second largest market for Marfan syndrome treatment during the forecast period due to drug availability and adoption of new treatment methods. The Marfan syndrome treatment market in Asia Pacific is expected to expand rapidly during the forecast period. Growth of the market in the region can be attributed to rapidly developing health care infrastructure.

Key players operating in the global Marfan syndrome treatment market are Sanis Health, Inc., Novartis Pharmaceuticals Corporation, Baxter Healthcare Corporation, Sanofi, Merck & Co., Inc., ANI Pharmaceuticals, Inc., Validus Pharmaceuticals, Inc., and AstraZeneca, among others.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

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The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

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Marfan Syndrome Treatment Market

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