A knockout mouse is a laboratory mouse (a biological model) in which a target gene has been disrupted or inactivated. The loss of gene activity frequently results in changes in the mouse's phenotypic characteristics (behavior, appearance, and other observable biochemical characteristics). This, in turn, allows in vivo studies of gene function, disease research, and drug development. Knockout mice are a powerful tool for analyzing gene function during development and in disease process.
Emergence of CRISPR as a powerful tool in the field of biomedical research, rising burden of obesity, increasing prevalence of cancer, cardiovascular diseases, diabetes, autism, schizophrenia, and rare diseases are some of the pivotal factors that are anticipated to propel the demand of knockout mice models in the near future.
Incessant grants/funds supporting cancer research studies, agreements & collaborations strengthening cancer research, increasing biomedical research activities in prominent markets such as the U.S., Australia, rising pharmaceutical & biotechnology R&D activities in Korea, increasing translational and biomedical research in Singapore, international alliances for R&D activities, growing public and private investments in life sciences sector, upsurge in animal research in Malaysia, growing pharmaceutical, biotechnology & research industries in Brazil, Saudi Arabia and the UAE are other driving factors that are expected to provide impetus to the market.
Increasing focus of associations such as International Mouse Phenotyping Consortium (IMPC) & International Knockout Mouse Consortium (IKMC) on the development of knockout mice is likely to unlock new areas of biology and lead to novel drug target discovery. .
In terms of types, the knockout mice models market has been divided into conditional knockout, constitutive knockout, inducible knockout, and tissue-specific knockout. Conditional knockout mice models are made by engineering recombinase specific targets. This enables the deletion of a gene in a tissue- and time-specific manner. Constitutive knockout mice models are created to carry an inoperative gene. It permanently inactivates a target gene in every cell of the organism. Inducible knockout mice models are conditional biological models, in which target gene of interest can be inactivated at a given point of time. It inactivates gene expression in a time-controlled manner. Tissue-specific knockout mice models are conditional biological models, in which target gene can be inactivated in a specific tissue or tissues such as the brain, intestine, muscles, skin, and all the other tissues.
In terms of type of indications, the knockout mice model market has been further classified into obesity, cancer, cardiovascular diseases, diabetes, neurological disorders, and others. Knockout mice models for cancer, cardiovascular diseases, diabetes & neurological disorders segments are well-established and hence their availability for these indications is not a concern. However, the supply of knockout mice models for neurological disorders and rare diseases is low; therefore, their availability for these indications is a concern. The knockout mice models for obesity, cancer, cardiovascular diseases, diabetes are priced relatively lower than the knockout models for neurological disorders and rare diseases due to the demand-supply gap. Based on geography, the knockout mice model market is segment into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.
Key players operating in the global knockout mice model market are Charles River Laboratories, Inc., The Jackson Laboratory, ENVIGO (Harlan Laboratories, Inc.), Taconic Biosciences, Inc., genOway, Cyagen Biosciences, Inc., Horizon Discovery Group PLC (Sage Labs, Inc.), Deltagen (TRANS GENIC INC.), and Ozgene.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.