Histone Deacetylase Inhibitors Market: Overview
Histone deacetylase inhibitors (HDIs, HDAC inhibitors, HDACi) are chemical compounds that interfere with and inhibit histone deacetylases. Histone deacetylases inhibitors are a new class of anti-cancer agents. HDACs play an important role in non-epigenetic and epigenetic regulations including apoptosis, cell cycle, and death apoptosis. Histone deacetylase inhibitors are emerging compounds with potential application in prognosis, treatment, and diagnosis of cancer. Histone deacetylase inhibitors accumulate acetylated nuclear histone in normal tissues and tumors. Hence, the inhibition results in acetylation transcription factors including estrogen receptor-alpha, p53, and GATA-1. These enzymes are found in plants, animals, bacteria, and fungi. There are about 18 known human HDACs, which are classified into four classes based on their structures. Class I includes histone deacetylase 1, histone deacetylase 2, histone deacetylase 3, and histone deacetylase 8. Class II includes histone deacetylase 4, histone deacetylase 5, histone deacetylase 7, and histone deacetylase 9. Class III includes histone deacetylase 6 and histone deacetylase 10, whereas class IV includes histone deacetylase 11.
Histone Deacetylase Inhibitors Market: Key Trends
The global histone deacetylase inhibitors market is projected to grow at a rapid pace during the forecast period. Rise in prevalence of cancer across the globe resulting in the increase in the need for improved and effective therapies is a major factor anticipated to drive the global histone deacetylase inhibitors market during the forecast period. According to the World Health Organization, cancer is the second major cause of death globally. Cancer accounted for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths occurs due to cancer and about 70% of deaths occur in low and middle income countries. Additionally, increase in collaboration among histone deacetylase inhibitors manufacturers and research & development on treatment of cancer and other chronic diseases are expected to propel the global histone deacetylase inhibitors market. However, uncertainty issues and inadequate reimbursement for histone deacetylase inhibitors are likely to restrain the global market during the forecast period.
Histone Deacetylase Inhibitors Market: Segmentation
The global histone deacetylase inhibitors market can be segmented based on class, application and end-user. In terms of class, the market can be classified into class I HDACs, class II HDACs, class III HDACs, and class IV HDACs. Based on application, the global histone deacetylase inhibitors market can be categorized into neurology, oncology, and others. Oncology is expected to be a major segment of the market due to large patient population and increase in the need for newer therapies to treat cancer. FDA-approved products currently available in the market include Vidaza, orinostat (Zolinza), Dacogen, and Romidepsin (Istodax). However, pharmaceutical companies are investing in R&D and pre-clinical activities of histone deacetylase inhibitors for treatment of different diseases. In terms of end-user, the market can be divided into hospitals, specialty clinics, and research & academic institutes.
Histone Deacetylase Inhibitors Market: Regional Analysis
Based on region, the global histone deacetylase inhibitors market can be segmented into North America, Asia Pacific, Europe, Latin America, and Middle East & Africa. North America is projected to lead the global market during the forecast period, followed by Europe. Dominance of the two regions is attributed to high income of the population, high R&D spending capacity, early adoption of innovative therapeutics, and well-established health care infrastructure. Asia Pacific is expected to be the fastest growing market owing to improved health care infrastructure, increase in cancer patient population, and rise in government initiatives.
Histone Deacetylase Inhibitors Market: Competitive Landscape
Key players operating in the global histone deacetylase inhibitors market include Celleron Therapeutics Ltd., Novartis International AG, Pfizer, Inc., Celgene Corporation, Eisai Co., Ltd., Merck & Co., AstraZeneca plc, Acetylon Pharmaceuticals, Inc., and Envivo Pharmaceuticals.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
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The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
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The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
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