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Global Endothelial Dysfunction Market: Synopsis

Endothelium is an inert lining of the blood vessels which act as highly specialized and metabolically active interface between the blood and the underlying tissues. The basic activities of endothelium encompass mediation of coagulation, platelet adhesion, immune function and control of volume and electrolyte content of the intravascular and extravascular spaces. Endothelium dysfunction can be defined as partial or complete loss of balance between vasodilating and vasoconstricting substances produced by the endothelium.

Endothelium dysfunction can contribute to several disorders such as hypertension, diabetes, hypercholesterolaemia, Behcet's disease among others. Endothelium dysfunction is now regarded as an early pivotal event in atherogenesis and has been considered an important event in the development of micro vascular complications in diabetes. Nitric oxide reduction is regarded as one of the prominent features of the endothelial dysfunction. Nitric oxide has following physiological effect which contributes to the inhibition of atherosclerosis which include reduction in LDL oxidation, decrease in platelet aggregation to the endothelium, inhibition of smooth muscles cell proliferation and prevention of leukocyte adhesion and infiltration into the vessel.

Global Endothelial Dysfunction Market: Trends and Prospects

The testing and diagnosis method for endothelial dysfunction include angiography with acetylcholine injection, however due to complex and invasive nature of diagnosis till date it has never been used beyond research activities. The non-invasive method to measure endothelial dysfunction comprises percent flow mediated dilation method measured by Brachial Artery Ultrasound Imaging devices. Though the technique is simple yet the acceptance across globe is hampered due to variation in results. A negative correlation between percent flow mediated dilation and baseline artery size is recognized as a fundamental scaling problem, leading to biased estimates of endothelial function. In 2003, FDA approved device EndoPAT which works by measuring Reactive Hyperemia Index (RHI) during nits clinical trials has shown significant results and up to 80% sensitivity as compared to acetylcoline angiogram.  Endothelial function can be improved significantly by exercise, smoke cessation, weight loss in overweight or obese persons, and improved diet. In past few years there has been a significant inclination by leading towards development of variety of novel drugs for treating endothelial dysfunction.

Some of the pipelined and available drugs in the market include maxacalcitol, S-adenosyl methionine, MC-1575 and paricalcitol among others. Some of the prominent drivers to the market include exponential rise in number of obese population, reduced physical activities and diabetes leading to increase in chances of acquiring cardiovascular diseases. Such factors have effectively contributed towards the growth and acceptance of variety of drugs and other therapeutics in past will continue to drive the market in forthcoming years as well. Advances in recombinant and gene therapy are also favoring the growth of endothelial dysfunction drugs uptake and can be an opportunity area for new entrants in the market.

Global Endothelial Dysfunction Market: Regional Outlook

Geographically North America and Europe market is currently the leading market for the endothelial dysfunction products due to high involvement of research and development, advanced medical facilities and broad awareness related to cardiovascular diseases and other related diseases. Lack of government interventions and funds to conduct research and development have affected the growth and revenue share for emerging and developing nations. With the substantial rise in cardiovascular and diabetic case in the Asia-Pacific and Middle East countries in upcoming years the demand for endothelial dysfunction market is likely to grow in these regions in next 5-7 years.

Global Endothelial Dysfunction Market: Key Players

Some of the key players in the market include Abbott Laboratories, Chugai Pharmaceutical Co., Ltd., Johnson & Johnson, Glucox Biotech AB, Stealth Peptides Inc. among other prominent players in the market.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Endothelial Dysfunction Market