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Down syndrome is a rare chromosomal disorder that occurs when a person has a partial or total extra copy of chromosome 21. It is also known trisomy 21, characterized by lifelong mental retardation, muscular hypotonia, and poor muscle tone, often associated with a characteristic distinct facial appearance and other problems such as developmental delays, flattened facial features, short neck, small head, protruding tongue, and anomalies such as cardiac, gastrointestinal, or endocrine defects. The cause of the disease is still unknown. Development of the children with Down syndrome varies in severity; therefore, development problems range from moderate to serious. It is not possible to predict the future development of children with this syndrome. Children with Down syndrome may also have small, upturned, almond-shaped eyes, small facial features, large tongue, and broad, short hands with a single crease on the palm, poor muscle tone, relatively short fingers and excessive flexibility. According to the Centers for Disease Control and Prevention, in the U.S. nearly 1 in every 1,000 children and teenagers (0 to 19 years old) had Down syndrome in 2002. Around 83,000 children and teenagers were living with this syndrome in the U.S in 2012.

Increase in research & development, introduction of novel disease therapies, rise in demand for effective therapies among patients, and increase in prevalence of the disease are projected to fuel the global Down syndrome market during the forecast period. According to the European Down syndrome Association (EDSA), Down syndrome occurs at the rate of about 1 per 1000 births. Presently, the life expectancy of a person with this syndrome is around 60 to 65 years, with some living even beyond this age in Europe. In the U.S the average medical care costs were 12 times higher for Down syndrome children aged between 0 and 4 years as compared to children without Down syndrome of the same age with private insurance.

 The global Down syndrome market can be segmented based on disease type, treatment, and region. In terms of disease type, the Down syndrome market can be categorized into complete trisomy 21, translocation trisomy 21, and mosaic trisomy 21. Based on treatment, the Down syndrome market can be divided into occupational therapies, speech therapies, physical therapies, and others. No specific treatment is known that can cure this syndrome; however, seizures can be reduced with anticonvulsant drugs, and other medical problems can be reduced and controlled by certain therapies. As of March 2018, the Down syndrome treatment drugs pipeline comprises 14 drug candidates, which are in different stages of development. These pipelines include gene therapy, small molecules, vaccines, and others drug candidates that are developed as recombinant peptides and proteins. Most drug candidates for the treatment of this syndrome are in the clinical stage of development. This is expected to lead to more drug approvals for the treatment of this syndrome.  For instance, NN 351 exhibited positive results in the pre-clinical trial by reducing the overall hyperactivity and increasing learning and memory abilities in transgenic mice with Down syndrome.

In terms of region, the global Down syndrome market can be categorized into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America accounted for a major share of the global Down syndrome market. According to a Research Office Legislative Council Secretariat report, there are over 30 million people suffering from rare diseases in the U.S. Strong focus on R&D and government aid to promote R&D are projected to propel the Down syndrome market. Europe was the trailing region in terms of revenues in the rare disease treatment drugs sector in the world.

Players operating in the global Down syndrome market include Eisai Co Ltd, F. Hoffmann-La Roche Ltd, NeuroNascent, Inc., AC Immune, Aelis Farma SAS, QR Pharma, Inc., and ManRos Therapeutics. 

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

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3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

With a robust experience in creating exceptional market reports, Transparency Market Research has emerged as one of the trusted market research companies among a large number of stakeholders and CXOs. Every report at Transparency Market Research goes through rigorous research activity in every aspect. The researchers at TMR keep a close watch on the market and extract beneficial growth-boosting points. These points help the stakeholders to strategize their business plans accordingly.

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Here's how Transparency Market Research helps the stakeholders and CXOs through the reports:

Inculcation and Evaluation of Strategic Collaborations: The TMR researchers analyze recent strategic activities like mergers, acquisitions, partnerships, collaborations, and joint ventures. All the information is compiled and included in the report.

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Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Down Syndrome Market

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