Conjugated polymer nanoparticles (CPN) are fluorescence emitting entities, which find applications in bioimaging, research & development, and photo optics. CPNs comprise light emitting polymers at the core and are encapsulated with hydrophilic polymer coating. Fluorescent imaging allows real time structural and functional study and visualization of cellular and molecular entities, without interfering the biological processes. Moreover, these imaging and visualization techniques are highly sensitive and tunable as per requirements compared to conventional imaging techniques. These factors have lead to high expectation and preference for fluorescent imaging and visualization techniques. Fluorescent organic dye probes have been in use in bioimaging and R&D applications; however, these pose concerns such as low stability and photo bleaching. CPNs, on the other hand, offer high photoluminescence quantum yield often termed as brightness, better stability, rapid emission rate, and non-blinking behavior.
Conjugated polymer nanoparticles are available in various colors in the range of 450 nm to 680 nm. This wavelength augments deep penetration of light and high sensitivity. CPNs offer better luminance and bio-compatibility. These can be easily conjugated with biological or molecular entities such as antibodies, oligosaccharides, and peptides, which can aid in targeted imaging and visualization of cellular and molecular entities. Several suppliers are offering pre-conjugated CPNs with biological molecules such as antibodies. For instance, Stream Bio Ltd. has introduced streptavidin conjugated CPNs. These features have expanded the usage of CPNs in applications such as flow cytometry, cell imaging, immunohistochemistry, immunocytometry, ELISA, and Western Blotting. Certain CPNs are also available with iron oxide molecules at the core which helps visualization in magnetic resonance imaging (MRI). It further assists in manipulation and purification using magnets. However, adoption of conjugated polymer nanoparticles is low, owing to small number of suppliers, cumbersome production process, and lack of infrastructure. Increase in R&D expenditure for scientific studies by public and private sectors and rise in access to these advanced technologies are anticipated to fuel the uptake of CPNs in the near future.
The global conjugated polymer nanoparticles market can be segmented based on product, conjugate, application, end-user, and region. In terms of product, the conjugated polymer nanoparticles market can be bifurcated into pre-conjugated and customized CPNs. Owing to technical difficulties in conjugating the CPNs at end-user site, suppliers are likely to offer pre-conjugated CPNs in the near future. Based on conjugate, the global conjugated polymer nanoparticles market can be classified into antibody, streptavidin, biotin, protein A, and others. In terms of application, the conjugated polymer nanoparticles market can be categorized into bioimaging, in vitro diagnostics, and life sciences R&D. Based on end-user, the conjugated polymer nanoparticles market can be divided into hospitals, diagnostic centers, academic research institutes, pharmaceutical & biotechnology industries, and others.
In terms of region, the global conjugated polymer nanoparticles market can be segmented into North America, Europe, Asia Pacific, and Rest of the World. High adoption of technologically advanced clinical research tools and high R&D expenditure by the public and private sectors in the U.S. are anticipated to contribute to the growth of the conjugated polymer nanoparticles market in North America. Europe is projected to account for significant share of the global market owing to well-established health care infrastructure and large base of pharmaceutical and biotechnology industries. Increase in public and private sector investment in developing health care and R&D infrastructure in emerging markets such as China and India is expected to augment the market in Asia Pacific during the forecast period.
There are limited number of suppliers of conjugated polymer nanoparticles in the global market. Moreover, several public sector universities and research institutes invest in the development of new CPNs. Key players in the global conjugated polymer nanoparticles market include Stream Bio Ltd., Spherotech, Inc., and Bio Trend.
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