Complex regional pain syndrome is a debilitating chronic pain condition causing intense pain particularly in the arms, hands, legs, or feet. This syndrome is characterized by pain, swelling, vasomotor instability, limited range of motion, skin color changes and patchy bone demineralization. CRPS is often regarded to be caused as a result of malfunction of failure of peripheral and central nervous system and therefore also sometimes referred as reflex sympathetic dystrophy syndrome. Complex regional pain syndrome (CRPS) is classified into two similar forms termed as CRPS type 1 (Reflex Sympathetic Dystrophy or RSD) and CRPS type 2 (Causalgia). The former type mentioned has been used for individuals with confirmed nerve injuries while the latter type is used to refer patients without any confirmed nerve injury. 
 
It is noteworthy to mention that the disease prevalence is very low and therefore classified as an orphan disease. Furthermore, since the sympathetic nervous systems affect several systems simultaneously, development of drugs for treating complex regional pain syndrome had been painstaking task for the researchers. However, the expanding knowledge base in neurology and medicine provides unique and underserved market opportunity for drugs and products in complex regional pain syndrome disease.
 
Presently there is no cure for the disease but drug therapies help in alleviating the pain associated with the disease as wells reduce the progression of the disease. Multimodal therapy is prescribed for the treatment of chronic regional pain syndrome which includes psychotherapy, rehabilitation therapy and drug therapy. Drug therapy for CRPS includes non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen) used to treat moderate pain while corticosteroids such as prednisolone and methylprednisolone are prescribed to treat inflammation and edema in the early stages of CRPS. Drugs effective in neuropathic pain are also administered to patients with CRPS. 
 
These drugs include gabapentin, amitryptiline, nortryptiline and duloxetine. Other therapeutic drugs useful in complex regional pain syndrome (CRPS) include oxytocins, morphine, hydrocodone, vicodin, N-methyl-D-aspartate (NMDA) receptor antagonists (dextromethorphan) and botulinum toxin injections. Several emerging therapies are being evaluated for the treating CRPS which include intravenous immunoglobulin (IVIG), ketamine and hyperbaric oxygen therapy.
 
Administering of calcitonin subcutaneously or by intra-nasal spray over 3-4 weeks is being studied for benefits against CRPS disease. Similarly, the experimental therapies such as motor cortex and deep brain stimulation are also being studied which may provide breakthrough improvement in the CRPS treatment therapy. Recently, Neridronate (amino bisphosphonate) has been studied for its effects on CRPS and has demonstrated significant reduction in symptoms. This molecule has been awarded with orphan designation status by the FDA but has not yet approved. We can expect that this drug molecule may enter the market upon successful completion of clinical trials.
 
The National Institutes of Health (NIH) supports research on complex regional pain syndrome through funding for the National Institute of Neurogical Disorders and Stroke (NINDS). Some of the companies in the global complex regional pain syndrome (CRPS) therapeutics market which are engaged in the research and development of pain management products for treating CRPS disease include Abiogen Pharma S.p.A., AlgoRx Pharmaceuticals, Inc., Amgen Inc.,Bayer AG, Celgene Corporation, Cell Targeting Technologies, CeNeS Pharmaceuticals plc, Danish Pain Research Center, Eli Lilly & Co., Endo Pharmaceuticals, Forest Laboratories Inc., GlaxoSmithKline plc, Grünenthal GmbH Johnson & Johnson, Justus Liebig University Giessen, King Pharmaceuticals Inc., Lee\'s Pharmaceutical Holdings Limited, National Institute of Nursing Research (NINR), NeurogesX, Inc., Pfizer, Inc., Stichting Achmea Slachtofferhulp Samenleving, and University of California.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

Custom Market Research Services

TMR offers custom market research services that help clients to get information on their business scenario required where syndicated solutions are not enough.

REQUEST CUSTOMIZATION

Complex Regional Pain Syndrome Therapeutics

Pre Book