Carglumic acid is an orphan drug that is utilized for treatment of patients with hyperammonemia, which implies deficiency of N-acetylglutamate (NAG) synthase. Well known as N-carbamoyl-L-glutamic acid (NCGA) or Carbaglu, carglumic acid stimulates the initial enzyme in urea cycle, which helps in detoxification and removal of ammonia from blood cells. Carglumic acid is on the verge of becoming an indispensable therapeutic tool for managing life-threating & rare inborn metabolic disorders that affect the urea cycle.

Carglumic Acid holds Potential in Accelerating Cancer Cell Suppression and Promoting Apoptosis

Analysis of in vivo models have showcased carglumic acid to stimulate liver carbamoyl phosphate synthetase. Although carbamoyl phosphate synthetase has a relatively lower affinity for carglumic acid than N-acetylglutamate (NAG), carglumic acid has been represented in vitro to activate carbamoyl phosphate synthetase, being much more effective in preventing ammonia intoxication. This orphan drug is currently gaining huge traction in treating patients with hyperammonemia, a rare congenital disorder caused by genetic defects pertaining to urea cycle enzymes. Carglumic acid also holds potential in accelerating cancer cell suppression, thereby promoting apoptosis in various types of cancers such as lung cancer and pancreatic ductal adenocarcinoma. These Factors will determine the future expansion of the market for carglumic acid across the globe.

carglumic acid market

Researchers across the globe are working on the development of “whole exome sequencing” procedure, with an aim of preventing intellectual disability in children through the combination of metabolomics analysis of carglumic acid and genome sequencing. Carglumic acid is further being utilized for application in enhancing ammonia detoxification in patients with organic acidurias. Transparency Market Research’s new report states that the global carglumic acid market will reflect an impressive expansion through the forecast period (2017-2026). Worldwide sales of carglumic acid is estimated to reach revenues worth nearly US$ 190 Mn by 2026-end.

North America to Remain Dominant in Global Carglumic Acid Market

North America will continue to dominate the global carglumic acid market, accounting for more than one-third market revenue share during the forecast period. Carglumic acid has gained significant traction among North American healthcare professionals for treating hyperammonemia. Researchers in the region are focusing on adjunctive treatment and maintenance therapy associated with acute hyperammonemia and chronic hyperammonemia, which are caused by deficiency of N-acetylglutamate synthase (NAGS) in elder population and pediatric patients. Regulatory bodies and pharmaceutical companies in the region are also focusing on patient education concerned with dosage and use of carglumic acid, so as to prevent patients from any side effects.

Tablet for suspension is anticipated to remain the most lucrative delivery format of carglumic acid, with sales estimated to exceed US$ 100 Mn by 2026-end. This delivery format of carglumic acid will witness a robust expansion in sales through 2026. In addition, sales of carglumic acid in the delivery format of orally disintegrating tablets will exhibit an impressive expansion through 2026.

Although hospital pharmacies are expected to remain the largest distribution channels for carglumic acid, sales in e-commerce is likely to witness a relatively faster expansion through 2026. Retail pharmacies will witness a comparatively faster expansion than hospital pharmacies in the market, however market revenue share of the former will remain relatively lower than the latter throughout the forecast period.

Competition Landscape

The global market for carglumic acid is dominated by few well-established players, who are continuously working on developing new formulations for carglumic acid. This has further created challenges for new market entrants in terms of product differentiation and quality. Key players profiled by TMR’s report include Recordati S.p.A, Civentichem LLC, and Dipharma Francis S.r.l. These players are continuous working on developing new formulations of carglumic acid to stay at the market’s forefront. For example – Dipharma, s Swiss pharmaceutical company, has recently announced its development of new & fast-dissolving formulation of the carglumic acid tablets, which remain stable at room temperature. In addition, Recordati S.p.A has announced inclusion of its Canadian affiliate, named Recordati Rare Diseases Canada Inc, thereby expanding its market presence.

Transparency Market Research (TMR) has compiled a new comprehensive report on the global carglumic acid market for the forecast period 2017 to 2026. The report offers insightful forecasts on global carglumic acid market, and has examined the market in detail, providing key market dynamics inclusively. In addition to the provision of intelligence on latest trends, restraining factors, and fostering factors affecting the market expansion, the report includes analysis on data pertaining to multiple market parameters.

Report Structure

The report’s beginning chapter presents an executive summary of global market for carglumic acid. A précis of global carglumic acid market is delivered in this chapter. Additionally, important market numbers such as historical (2012-2016) & forecast (2017-2026) CAGRs have been rendered, regarding the market segments particularly. Based on sales expansion and revenues collected from carglumic acid sales globally, information about remunerative regions for growth of the carglumic acid market is delivered in the report.

A chapter titled overview proceeds after the global carglumic acid market’s executive summary, which incorporates the definition of “carglumic acid” that follows a succinct market introduction. Overview of the global carglumic acid market indicates a clear scenario of global carglumic acid market’s broad scope. The chapters subsequent to overview illuminate key dynamics impacting global demand for carglumic acid, and engulfs imperative points that include the global economy, the bottom line of enterprises, and the fiscal stimulus. The report’s following chapters comprise information on pricing analysis as well as cost structure of the carglumic acid market.

Market Taxonomy

Moving further the report propounds analysis on global market for carglumic acid with the help of a segmentation analysis. Global market for carglumic acid is divided into three key segments, which are distribution channel, delivery format, and region. Revenue comparison and Y-o-Y growth comparison, in addition to market share comparison of these segments are contained in the report, for offering most significant market numbers appertaining to the segmentation analysis. The global carglumic acid market has been characterized regionally into six key segments namely, Asia-Pacific excluding Japan (APEJ), Latin America, North America, Europe, Japan, and Middle East & Africa (MEA).

Region

Delivery Format

Distribution Channel

North America

Tablet, orally disintegrating

Hospital Pharmacies

Latin America

Tablet, for suspension

Retail Pharmacies

Europe

 

E-Commerce

Japan

 

 

APEJ

 

 

MEA

 

 

 Competition Landscape

A scrupulous analysis on global carglumic acid market’s competition landscape is provided in the report, incorporating information about active industries that are contributing significantly to the market expansion. Occupancy of major market participants is tracked by the report with an intensity map. Emphasizing on profiling key market participants rigorously, this chapter offers Insights about players based on the SWOT analysis, which elucidates strengths, weaknesses, opportunities, & threats affecting that specific market participant. In addition, information on key developments, key financials, company overview, and product overview pertaining to market players is also comprised in this chapter of the report. The competition landscape is a crucial chapter for this report’s readers, as it gives all necessary knowledge appertaining to companies, coupled with the novel strategies employed by them to stay at global carglumic acid market’s front edge.

Research Methodology

A research methodology, which is proven and tested, has been used by TMR’s analysts while developing the report on carglumic acid market, which has aided them in providing precise & accurate insights on the carglumic acid market. Research methodology adopted entirely depends on the primary and the secondary researches, for further gaining necessary information about global carglumic acid market. This information attained is then validated by the analysts several times, just to ensure its authenticity as well as for making it an authoritative reference for report readers.

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