Bone Substitutes Market - Introduction

Bone substitute is defined as a synthetic, biologically organic, or inorganic combination which is used in the treatment of bone defects. Various bone substitutes have been used in the past 50 years. Bone substitutes are primarily categorized into ceramics (TCP, hydroxyapatite, and calcium sulfate), bone grafts (xenograft, autograft, and allograft), and growth factors (PRP, DBM, BMPs). Ideal properties of a bone substitute include biocompatibility, thermally nonconductive, sterilizable, and should not evoke any adverse inflammatory response. Additionally, it should be osteoconductive, osteoinductive, and resorbable.

Bone substitutes are widely used in orthopedic surgeries for a number of applications. Bone grafting is the second most frequent tissue transplantation procedure performed across the world. Over two million bone graft procedures are performed every year, with more than 500,000 implanted in the U.S. alone. This is due to ease of use & handling, improved safety profiles, intraoperative cost & time advantages, and adaptability with a variety of clinical challenges.

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Bone Substitutes Market – Competitive Landscape

DePuy Synthes

Founded in 1895, DePuy Synthes is headquartered in Warsaw, Indiana. The company is the part of the Johnson & Johnson Family of Companies. DePuy Synthes offers comprehensive portfolio of orthopaedic and neuro products and services for joint reconstruction, trauma, spine, sports medicine, neuro, cranio-maxillofacial, power tools and biomaterials.


Founded in 1949, Medtronic is a leading medical devices company engaged in the development, manufacturing, and marketing of products for alleviating pain and restoring normal health of patients

The company operates through four business segments: cardiac & vascular group, minimally invasive therapies group, restorative therapies group, and diabetes group

The Medtronic Orthopedic Solution offering products for total joint replacement is a part of company’s Spine division within the Restorative Therapies Group.

Zimmer Biomet

Established in 1927, Zimmer Biomet is a one of the prominent player in the medical device market catering to customers present in musculoskeletal health care arena

The company manufactures and markets orthopedic reconstructive products; sports medicine, biologics, extremities & trauma products; spine, bone healing, craniomaxillofacial & thoracic products; dental implants and related surgical products

The company's offers its products to orthopedic surgeons; neurosurgeons; oral surgeons, dentists, hospitals, distributors, health care dealers and other specialists in orthopedic market

Its products are used to treat injuries, bone, joint, and soft tissue disorders

The company operates in more than 25 countries worldwide, and its products are distributed in more than a 100 countries through its wide distribution network

Zimmer Biomet has over 8,000 patents related to technologies incorporated in its products.


Founded – 1941, Kalamazoo, U.S. Stryker is a global medical device company offering its products in orthopedic implants, trauma, and replacement surgeries; endoscopic and communication systems; emergency medical equipment and intensive care disposable products; surgical equipment and surgical navigation systems; and other products.

The firm operates through three business segments: Orthopedics, MedSurg, and Neurotechnology and Spine. The orthopedic segment offers joint replacement products which includes brands like Mako Partial Knee, Mako Total Knee, and  Restoris MCK

As of December 2016, Stryker has registered over 2,184 U.S. patents and 3,454 international patents

The company offers its medical devices to customer in hospitals and other health care facilities in the U.S. It also offers products through subsidiaries and branches and other third-party dealers and distributors in more than 100 countries.

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Bone Substitutes Market – Dynamics

Increase in the number of cases of bone disorders across the world drives the global bone substitutes market

According to the International Osteoporosis Foundation, the global incidence of fractures is anticipated to increase by 240% in women and 310% in men by 2050. Moreover, increase in the geriatric population, rise in research & development expenditure, and surge in awareness among end-users contribute to the growth of the global bone substitutes market. The market is expected to witness significant demand during the forecast period. However, risk associated with immune response and disease transmission are the major factors hampering the growth of the global bone substitutes market. Moreover, stringent regulatory framework and high cost are the other factors restraining the market. Furthermore, ethical issues associated with bone harvesting hampers the growth of the global bone substitutes market in some regions

Asia Pacific to Remain a Forerunner in the Demand for Bone Substitutes

The market in Asia Pacific is projected to expand at a high CAGR during the forecast period, driven by large patient pool, increase in government initiatives, and developing health care infrastructure in India and China. The market in Latin America and Middle East & Africa is anticipated to be driven by increase in investments by leading players in these regions and rise in prevalence of orthopedic diseases.

Bone Substitutes Market – Segmentation

The Bone Substitutes market can be bifurcated depending upon:

  • Type
  • Application
  • End-use industry
  • Geography

Bone Substitutes Market Segmentation – By Type

Depending on the type, the Bone Substitutes market can be classified into:

  • Ceramics
  • bone grafts
  • Growth factors

Bone Substitutes Market Segmentation – By Application

Based on the application, the Bone Substitutes can be bifurcated into:

  • Oncologic surgery
  • Revision prosthetic surgery
  • Traumatology
  • Spine surgery

 Bone Substitutes Market Segmentation – By end-user

Depending on the end-use industry, the Bone Substitutes market can be fragmented into:

  • Hospitals
  • Orthopedic clinics
  • Others

The report on Bone Substitutes market is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The Bone Substitutes market report provides in-depth analysis of parent market trends, macroeconomic indicators and governing factors along with market attractiveness as per segments. The Bone Substitutes market report also maps the qualitative impact of various market factors on Bone Substitutes market segments and geographies.

Regional analysis for Bone Substitutes market includes:

  • North America
  • Latin America
  • Western Europe
  • Eastern Europe
  • Asia Pacific excluding Japan (APEJ)
  • Japan
  • Middle East & Africa (MEA)

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The study is a source of reliable data on:

  • Market segments and sub-segments
  • Market trends and dynamics
  • Supply and demand
  • Market size
  • Current trends/opportunities/challenges
  • Competitive landscape
  • Technological breakthroughs
  • Value chain and stakeholder analysis

The regional analysis covers:

  • North America (U.S. and Canada)
  • Latin America (Mexico, Brazil, Peru, Chile, and others)
  • Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
  • Eastern Europe (Poland and Russia)
  • Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
  • Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

  • A complete backdrop analysis, which includes an assessment of the parent market
  • Important changes in market dynamics
  • Market segmentation up to the second or third level
  • Historical, current, and projected size of the market from the standpoint of both value and volume
  • Reporting and evaluation of recent industry developments
  • Market shares and strategies of key players
  • Emerging niche segments and regional markets
  • An objective assessment of the trajectory of the market
  • Recommendations to companies for strengthening their foothold in the market   

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Bone Substitutes Market

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