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Reperfusion Injury Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2016 - 2024

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Reperfusion Injury Market: Description

Reperfusion injury is referred to as the tissue damage caused due to absence of blood supply or lack of oxygen such as damage to brain after stroke or heart post episodes of ischemia. Such kind of restoration of blood supply results into inflammation and oxidative damage through the induction of oxidative stress rather than normal functioning. Confined infarct size and reduced mortality can be achieved by prompt restoration of blood supply to myocardium. However, this restoration is also known to result in the cardiac damage and eventually reperfusion injury. A delay in reperfusion therapy has been attributed for such damage. 

Reperfusion of ischemic tissue is often associated with microvascular injury. The duration for which a tissue can survive deprived of oxygen varies, but eventually the tissue is rendered necrotic. The blood supply restoration usually minimizes the damage, but reperfusion of tissue post thrombolytic procedures demonstrated that the extent of injury often increased on restoration of the blood supply. The studies have also attributed this reperfusion injury, to the activity of free radicals.

Reperfusion Injury Market: Segmentation

The global reperfusion injury market can be segmented based on therapy type, injury type and geography. Drugs used for treating reperfusion injury are classified on the basis of mode of action, target site, route of administration and molecule type. Geographically, the global reperfusion injury market can be categorized into four major regions namely, North America, Europe, Asia-Pacific and Rest of the World. Primary percutaneous coronary intervention (PCI) and thrombolysis, form the primary reperfusion therapies and are often used for treating acute coronary syndromes.

Reperfusion Injury Market: Overview

Allopurinol, one of the drugs in clinical trials helps inhibit production of free radicals thereby known to reduce the size of infarct. However the drug has not been universally successful. An enzyme called recombinant superoxide dismutase has been under investigation as free radical scavenger that detoxifies oxygen. Various other drug molecules in clinical trials include cyclosporine, MTP-131, bucillamine, recombinant proteins, type 5 adenylyl cyclase inhibitors, and synthetic peptides amongst others. Agents that specifically target proteins, transcription factors or ion channels, including PPAR, PKC agonists/antagonists, Phosphodiesterase-5 inhibitors, the ATP-dependent potassium channel and 3-Hydroxy-3-methyl glutaryl coenzyme A reductase are also promising.

However, currently no agent has been clinically approved for treatment of reperfusion injury. Studies demonstrating success in the clinical use have been disappointing for last few years though successful results have been observed on animals. The unclear solutions and lesser potential therapies that limit the free radicals generation on reperfusion are also under investigation in several clinical trials. New avenues for investigation are recently opened due to studies demonstrating involvement of inflammatory cytokines and their effects on neutrophiles. Additionally, a combination of better techniques for rapid reperfusion and use of neutrophil inhibitors and anti-oxidants will help in reduction of the enormous cost associated with the clinical trials for treatment of reperfusion injury. Other options under study for treatment of reperfusion injury include hypothermia treatment, post conditioning such as mechanical and pharmacologic have shown success in few patients.

Larger experiments exploring the potential of various therapeutic options in order to influence clinically relevant endpoints are yet awaited for options which are currently insufficiently demonstrated in clinical use of these reperfusion injuries.

Reperfusion Injury Market: Companies Mentioned in the Report

Apeptico Forschung und Entwicklung GmbH, Eustralis Pharmaceuticals Ltd., NeuroVive Pharmaceutical AB, Nyken BV, Stealth Peptides, Inc., Scynexis, Inc., and Vasade Biosciences, Inc. are some of the key players contributing to the global reperfusion injury market.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The study is a source of reliable data on:

  • Market segments and sub-segments
  • Market trends and dynamics
  • Supply and demand
  • Market size
  • Current trends/opportunities/challenges
  • Competitive landscape
  • Technological breakthroughs
  • Value chain and stakeholder analysis

The regional analysis covers:

  • North America (U.S. and Canada)
  • Latin America (Mexico, Brazil, Peru, Chile, and others)
  • Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
  • Eastern Europe (Poland and Russia)
  • Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
  • Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

  • A complete backdrop analysis, which includes an assessment of the parent market
  • Important changes in market dynamics
  • Market segmentation up to the second or third level
  • Historical, current, and projected size of the market from the standpoint of both value and volume
  • Reporting and evaluation of recent industry developments
  • Market shares and strategies of key players
  • Emerging niche segments and regional markets
  • An objective assessment of the trajectory of the market
  • Recommendations to companies for strengthening their foothold in the market 

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.


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