Bipolar disorder, formerly known as manic-depression, is a brain disorder which causes unusual shifts in energy, mood, activity, and ability to perform everyday tasks. It is considered as a lifelong disorder with no complete cure and discontinuation of its treatment could reverse the condition. A person with manic depressive condition experiences alternate manic episode, characterized by extreme happiness, hyperactivity, extreme irritability than usual, and depressive episode, characterized by extreme sadness, lack of energy, and feeling of helplessness. Bipolar disorder statistics from the World Health Organization (WHO) indicates bipolar disorder as the 6th leading cause of disability in the world. As per a study conducted by the National Institute of Mental Health (NIMH), bipolar disorder reduces 9.2 years of expected life span of a person, and one in five patients with bipolar disorder commits suicide. As per the NIMH, bipolar disorder can affect the children of parents who are suffering the disorder. It has been studied that the risk to a child is 20% to 30% when one parent is with the disorder, and when both parents are suffering from the disorder, the risk increases from 50% to 70%.
Rise in number of bipolar disorder problems and highly unmet medical needs are the key drivers of the bipolar disorder treatment market. Technological advancements in this field, increase in government support, and rise in awareness about the bipolar disorder and its treatments globally are projected to further fuel the demand for bipolar disorder treatment in the near future. However, continued utilization of generic medicines, stringent regulations, and side-effects related to the products of the treatment are expected to hamper the growth of the bipolar disorder treatment market during the forecast period. In addition, there are presently only two products in phase III trial, which indicates that bipolar disorder is likely to remain a field of high unmet need during the forecast period.
The global bipolar disorder treatment market is segmented on the basis of treatment, mechanism of action, disease indication, and region. Based on the treatment, the market is categorized into mood stabilizers, anticonvulsants, atypical antipsychotics, antidepressant drugs, and anti-anxiety drugs. The mood stabilizers segment is sub-segmented into lithium, valproic acid, divalproex sodium, carbamazepine, lamotrigine, and others. The anticonvulsants segment includes olanzapine, risperidone, quetiapine, lurasidone, and other drugs. Symbyax, fluoxetine, and olanzapine drugs are considered under the antidepressant drugs segment. The mood stabilizers segment is expected to hold a significant share of the global bipolar disorder treatment market owing to high sale of lithium drugs around the globe.
On the basis of mechanism of action, the global market is distributed into selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, benzodiazepines, beta blockers, and others. Selective serotonin reuptake inhibitors therapy is recommended as first-line therapy owing to its safe and effective mode of action; hence, this segment is expected to hold a large market share during the forecast period. In terms of disease indication, the global market is divided into three types of manic disorders: bipolar I, bipolar II, and cyclothymic. High prevalence rate of bipolar I manic disorder globally and new products launch in this sector are projected to account for a large market share of the segment during the forecast period.
The global market for bipolar disorder treatment is distributed over North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. The North America region leads the market for bipolar disorder treatment and is closely followed by Europe. Large share of these regions are due to increased awareness about bipolar disorder. Japan, China, and India are expected to be a fast growing bipolar disorder markets in Asia as key players in the market are developing their manufacturing facilities in the region.
Key players operating in the market are GlaxoSmithKline plc, Abbott Laboratories Inc., Bristol-Myers Squibb Company, Alkermes, Allergan, AstraZeneca, Indivior, Johnson & Johnson, Eli Lilly and Company, Gedeon Richter PLC, Merck & Co., Inc., and Pfizer Inc.
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