Tooth regeneration is a stem cell-based regenerative medical procedure that is used in tissue engineering and stem cell biology sectors. The tooth regeneration procedure replaces the damaged or lost tooth by growing it from autologous stem cells. Somatic cells are collected and reprogrammed to induce pluripotent stem cells and dental lamina with the help of reabsorbable biopolymer. Dental stem cells and cell-

activating cytokines are expected to be an approach for tooth tissue regeneration, as they have the potential to differentiate into tooth tissues in in vitro form and in vivo form. Tooth replacement therapy is considered to be a highly attractive concept for the next generation regenerative therapy, which is also known as bioengineered organ replacement. The usage and availability of different types of tooth regeneration has been evolving since the last century; however, further research still continues to develop its more clinical applications and reduce the adverse effect associated with the usage of tooth regeneration during surgery.

A major factor driving the tooth regeneration market is the high incidence of dental issues, witnessed globally. Rise in incidence of periodontics among young adults and the rising demand for stem cell tooth regeneration techniques, especially among the geriatric population, are a few other factors that are anticipated to drive the tooth regeneration market. Favorable reimbursement policies such as coverage of Medicaid insurance for dental loss treatment and emergence of new technologies such as laser tooth generation techniques are expected to propel the global tooth regeneration market. According to the World Health Organization, complete loss of teeth affects approximately 30% of the geriatric population between the ages of 65 and 74. However, prevalence rates are increasing in low and middle income countries. However, some factors such as preference for endodontic treatment over tooth regeneration products in major dental surgeries and local inflammatory activity, which results in chronic complications to dental replacements, is projected to restrain the market during the forecast period.

The global tooth regeneration market can be segmented based on application, end-user, and regions. In terms of application, the tooth regeneration market can be segmented into dentin, pulp, enamel, and others. The dentin segment accounted for a prominent share of the global tooth regeneration market in 2016, due to the increasing prevalence of dental surgery and the rising demand for tooth regeneration in cosmetic surgery, especially from emerging economies such as China, Brazil, and India. In terms of end-user, the market can be segregated into hospitals, dental clinic, aesthetics, ambulatory care centers, and others.

In terms of regions, the global tooth regeneration market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is projected to dominate the global tooth regeneration market during the forecast period due to increase in demand for dental services and stem cell research. According to the Dental health services of Canada, in 2015, the total expenditures on dental services in Canada amounted to US$ 13.6 Bn. The private sector expenditure was estimated to be US$ 12.7 Bn, while the public sector expenditure was estimated to be US$ 846 Mn. In April 2017, Unilever launched an in-clinic remineralisation regime to regenerate professionally advanced enamel serum. The brand claimed 82% of the enamel mineral regenerated after 3 days. Furthermore, the increasing prevalence of dental cavities & periodontics, especially in developing countries such as China and India has led to the increasing demand for orthopedic & dental surgery. According to World Health Organization, nearly 60% to 90% of school children and nearly 100% of adults have dental cavities. However, Asia Pacific is witnessing an increase in the incidence of dental surgery, general prosthetic fixation, periodontal inflammation, and other dental diseases. This, in turn, is anticipated to fuel the demand for cost-effective aesthetic and dental surgery. These factors are projected to drive the tooth regeneration market in Asia Pacific between 2017 and 2025.

Key players operating in the global tooth regeneration market include Unilever, Ocata Therapeutics, Integra LifeSciences, CryoLife, Inc., BioMimetic Therapeutics, Inc. (Wright Medical Group, Inc.), Cook Medical, and StemCells Inc.

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