Tangential flow filtration, also known as cross-flow filtration, is a highly useful downstream processing technique used in bio-manufacturing and also in the upstream process of cell harvesting (separation of cells from fermentation broth). It involves the introduced solution passing tangentially along the surface of the filter, with the pressure difference guiding constituents smaller than the pores through the filter. Tangential flow filtration is utilized in the separation and purification of a wide range of biomolecules such as antibodies, nucleic acids, and recombinant proteins. One advantage rendered by this technique is its ability to be applied to a wide range of biological fields such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology, besides its adaptability to a range of volumes for separation and purification. 

Tangential flow filtration is used to concentrate and desalt sample solutions ranging from 10ml up to thousands of liters. It offers several advantages such as easy scale-up and scale-down, effortless set-up and running, and conservation of time and money. This market is motivated by factors such as a rise in the manufacture of biologics, investments by major pharmaceutical companies and CMOs into newer facilities to accommodate the growing demand for biologics, and a requirement for efficient and economical technologies in downstream processing in bio-manufacturing. However, the market is also likely to be curbed by the presence of competing technologies such as centrifugation, direct flow filtration, and pre-coat filtration. The present market dynamics have shaped the need for new manufacturing facility designs which are flexible and exhibit high productivity to enable low-cost scale variations in a smaller footprint. This could be readily addressed by disposable single-pass tangential flow filters. Thus, newer products such as disposable technologies have tremendous potential to augment the development of tangential flow filtration during the forecast period. 

The tangential flow filtration market has been segmented on the basis of type of technology, type of product, end-user, application, and geography. Its technology-based divisions are ultrafiltration and microfiltration, while the product-centered ones are disposable tangential flow filtration systems, multi-use tangential flow filtration systems, and TFF filters (cassettes and cartridges), accessories, & spares. In terms of end-user, the market is divided into the following categories: biopharmaceutical organizations, academic & research institutes, CROs, and CMOs. The CMO segment is likely to progress due to the increasing outsourcing activities with respect to the manufacture of biologics. The primary revenue contributor, however, is anticipated to be biopharmaceutical organizations. Based on geography, the market is distributed over the following regions: North America, Europe, Latin America, Asia Pacific, Latin America, and Middle East & Africa. The market in North America is projected to be the leader, owing to the adoption of cutting edge technologies coupled with a favorable clinical trial scenario here. The single-use tangential flow filtration systems typically find widespread usage in start-ups and CMOs engaged in the production of biologic molecules for clinical studies. Asia Pacific represents a pharma emerging market which is progressively recording sound growth in the production of biologics, especially biosimilars, and is anticipated to be attractive for the business of tangential flow filtration systems. New products are also estimated to play a role. For instance, in January 2016, Sartorius Stedim launched a tangential filtration system suitable for scaling studies and low volume ultrafiltration over a wide range of surface areas. The system displayed the advantage of applicability to a wide range of bioprocessing domains such as purification of vaccines, monoclonal antibodies, recombinant proteins, and other cell derived components. Moreover, its ability to be used for scale-down models leads to a cost-efficient approach to R&D optimization and cGMP production. Such TFF solutions positively propel the market. 

Key players operating in the tangential flow filtration market include Danaher Corporation (Pall Corporation), Merck KGaA, GE healthcare, Spectrum Inc., Parker Hannifin Corp., Novasep,  TangenX Technology Corporation, and Sartorius AG.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Tangential Flow Filtration Market

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