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Small interfering RNA (siRNA) is a type of genetic medicine, which has potential to silence or knock down any over-expressed gene in a disease. It is also called short interfering RNA. These RNAs are widely used to evaluate the specific contribution of genes to a variety of cellular phenotypes including apoptosis, insulin signaling, cytokinesis, and cell differentiation. They are employed to recognize novel pathways and have a meaningful impact in validating targets for several diseases (such as AIDS, cancer, and hepatitis) and cellular processes. The mechanism of action of siRNA involves its introduction into a cell. The sequence of siRNA is designed in such a way that it matches with a short area of the targeted gene. Small interfering RNA is processed by a cell’s own enzymes to abolish mRNA of the target gene, thereby preventing the over-expression of the disease-causing gene. It is based on natural response of cells when they detect genetic abnormality or infection. It has certain advantages over different types of therapies available currently, for example, target-specificity, reduced secondary effects, and high specificity. The pre-clinical development of small interfering RNA compound is of shorter duration (around 15 to 24 months) than that of monoclonal antibodies (around 27 to 50 months) or other traditional small molecules (around 42 to 66 months). This shortening of the pre-clinical stage is attributable to the rational design of RNAs. This design comprises mathematical algorithms assembled in software in order to select the most suitable RNA sequence to silence a specific gene target. They usually act longer than other traditional medicines.

The small interfering RNA (siRNA) therapeutics market is expected to expand significantly during the forecast period, as only a few products are currently available in the market. For example, Britena is a product approved for skin de-pigmentation. Most of the small interfering RNA therapeutics is currently under clinical development. It would be marketed in the next few years. There exist more than 15 companies developing over 85 small interfering RNA therapies. Small interfering RNA is being studied for various disease areas. However, most of the studies are focused on the oncology area with 27 siRNA therapies under development by major pharma companies, followed by 14 therapies for infectious diseases and eight therapies for ophthalmology. Two of the most popular methods of delivering siRNA therapies are liposome-based systems and nanoparticle-based systems. Liposome-based systems are associated with liver-targeted pharmacokinetics, a phenomenon that restricts the therapeutic potential of siRNA therapies to other common diseases of the liver such as hepatocellular carcinoma, hepatitis, and hypercholesterolemia.

In terms of geography, the global small interfering RNA (siRNA) therapeutics market has been segmented into North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America dominates the market, followed by Europe. This can be attributed to the large number of ongoing clinical trials, increase in the expenditure on research and development, and availability of developed health care infrastructure in North America. Asia Pacific is an emerging market for siRNA therapeutics, due to the developing health care infrastructure and rising government expenditure on the health care industry in the region. On the other hand, lack of developed health care infrastructure and limited research and development activities in Middle East & Africa restrain the siRNA therapeutics market in the region.

Major players operating in the global small interfering RNA (siRNA) therapeutics market are GE Dharmacon, OPKO Health, Inc., Alnylam Pharmaceuticals, Arrowhead Research Corp, Sanofi Genzyme, Genecon Biotechnologies Co., Ltd., Arbutus Biopharma Corp, Silence Therapeutics AG, and Sylentis S.A.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Small Interfering Rna Therapeutics Market

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