Positive Allosteric Modulators Market: Introduction

  • Positive allosteric modulators (PAM) increase agonist affinity and/or efficacy. Affinity is the ability of a substance to bind to a receptor and efficacy is the ability of a substance to activate a receptor. If efficacy is zero, the substance is considered an antagonist.
  • GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that raise the activity of the GABAA receptor protein in the vertebrate central nervous system. GABAA receptor PAMs used as drugs have primarily sedative and anxiolytic effects.
  • Allosteric modulators can also stabilize one of the normal configurations of a receptor. Examples of positive allosteric modulators are benzodiazepines and barbiturates. Benzodiazepines are used to treat anxiety, panic attacks, seizures, insomnia, etc.
  • Positive allosteric modulators are particularly advantageous for neurotransmitter receptors
  • A positive allosteric modulator only activates receptors when the endogenous agonist is present
  • Allosteric modulators are helpful to the understanding of the structural and physicochemical properties of substances, which could provide the principles and rationale for allosteric drug discovery
  • Allosteric modulators offer a number of theoretical advantages compared to their competitive counterparts

Global Positive Allosteric Modulators Market: Key Drivers and Restraints

  • Globally, over 10 million people are living with Parkinson's disease (PD)
  • According to the World Health Organization (WHO), schizophrenia is a chronic and severe mental disorder affecting 20 million individuals across the world. This is projected to boost the growth of the global positive allosteric modulators market.
  • There are several diseases that lack drug therapy because of the difficulty in designing drugs to interact with the orthosteric sites. Therefore, use of allosteric modulators can provide better alternatives to the discovery of new drugs to treat these disorders. This factor is anticipated to fuel the growth of the global market.
  • However, side effects of medicines are expected to hamper the growth of the global positive allosteric modulators market during the forecast period. Severe side effects of barbiturate are lack of coordination, headache, vomiting, confusion, respiratory arrest, and death.

North America to Capture Major Share of Global Positive Allosteric Modulators Market

  • North America is projected to dominate the global positive allosteric modulators market during the forecast period due to increase in Parkinson's disease cases
  • According to the Parkinson's Foundation, in the U.S., around 930,000 people were suffering from Parkinson's disease in 2020, and the number is anticipated reach 1.2 million by end of 2030.
  • In the U.S., around 5.5 million people are affected with Alzheimer disease, and the global prevalence is estimated to be as high as 24 million
  • Rise in prevalence of Alzheimer disease is expected to drive the global positive allosteric modulators market during the forecast period
  • The prevalence of Parkinson’s disease in the U.K. is about one in 500 people, with around 127,000 people living with the disease presently. Rise in prevalence of Parkinson's disease is likely to augment the global market during the forecast period.

Key Players Operating in Global Positive Allosteric Modulators Market

  • F. Hoffmann-La Roche Ltd.
  • Pfizer, Inc.
  • Taj Pharmaceuticals Limited
  • Explicit Chemicals Pvt. Ltd.
  • Shaanxi Rebecca Bio-Tech Co., Ltd.
  • Zydus Cadila
  • ACADIA Pharmaceuticals, Inc.
  • M Somerset Pharmaceuticals, Inc.
  • Vertical Pharmaceuticals, LLC

Global Positive Allosteric Modulators Market: Research Scope

Global Positive Allosteric Modulators Market, by Disease Type

  • Parkinson’s Disease
  • Schizophrenia
  • Alzheimer’s Disease

Global Positive Allosteric Modulators Market, by Drug Type

  • Benzodiazepines
    • Diazepam
    • Clonazepam
    • Lorazepam
    • Oxazepam
  • Barbiturates
    • Methohexital
    • Phenobarbital
    • Secobarbital
  • Amantadine
  • Donepezil
  • Galantamine
  • Rivastigmine
  • Levodopa
  • Carbidopa

Global Positive Allosteric Modulators Market, by End-user

  • Hospitals
  • Clinics
  • Diagnostic centers
  • Others

Global Positive Allosteric Modulators Market, by Region

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • U.K
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

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Positive Allosteric Modulators Market