Humanized mouse models are used for basic research, safety assessment for large molecule therapeutics, modeling of certain human-specific infectious diseases, and efficacy testing of immunotherapy approaches. The human protein is expressed while the mouse protein is suppressed in all cells and tissues. Humanized mouse models are important tools required to conduct preclinical research, mimic human pathological conditions, test compound efficacy, and measure its effects on human proteins. The model requires accurate risk assessment and thorough analysis to preserve the physiological expression and regulation of the human gene inserted into the mouse genome. In order to determine the optimal expression and functionality of the human protein in a mouse environment, the genes and proteins of both, the mouse and human, are analyzed for accuracy and structure. Humanized mouse models are used in biomedical research including cancer biology, regenerative medicine, human hematopoiesis, infectious diseases, transplantation, and autoimmunity. They enable better understanding of disease pathways and ultimately improve the translational value of preclinical studies. 

Technological advancements, growing prevalence of cancer, research & development activities, and the rising adoption of personalized medicines are factors predicted to drive the global humanized mouse model market. According to the World Health Organization, cancer is the second leading cause of death globally and was responsible for 8.8 million deaths in 2015. Globally, nearly 1 in 6 deaths is caused by cancer. Government investment too plays a key role in motivating the market. On the other hand, regulations & laws formulated for ethical use of animals and increased use of rat models may hinder the global humanized mouse model market. 

The market has been segmented by model type into the genetic and cell-based varieties. The latter is further segmented into the PBMC, BLT, and CD34 categories. The growing application of CD34 models is expected to trigger the demand for them in the near future. In terms of application, the humanized mouse model market is classified into the following groups: oncology, immunology, infectious diseases, neuroscience, hematopoiesis, toxicology, and others. Based on end-user, the humanized mouse model market is categorized into the following sections: contract research organizations (CROs), pharmaceutical & biotechnology companies, and academic & research institutions. 

Geographically, the humanized mouse model market is distributed over North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America dominated the market due to preclinical activities by CROs, pharmaceutical R&D activities in the U.S., availability of support for research, growing monoclonal antibody production, increasing stem cell research in Canada, and government support for development of protein drugs. Europe is the second leading market for humanized mouse models owing to the increasing number of research and development activities. Asia Pacific is likely to grow at a higher rate on account of the burgeoning biomedical and medical research industries, increasing investments from the government & private sector, rising pharmaceutical & biotech R&D activities, and growing presence of global players in India. The availability of target patient pool as well as low-cost clinical trials are also important factors which are projected to propel the humanized mouse model market in Asia Pacific. 

Key players operating in this market include The Jackson Laboratory, Taconic Biosciences, Inc., Vitalstar Biotechnology Co., HuMurine Technologies, Ltd., Crown Bioscience Inc., Ingenious Targeting Laboratory, Axenis S.A.S, Trans Genic Inc., Harbour Antibodies BV, and GenOway S.A. 

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Humanized Mouse Model Market

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