Genetic engineering is a branch of biotechnology that deals with gene modifications or changes in genetic makeup. By using prolonged tissue culture in genetic engineering, viruses can be attenuated or modified. This results in the growth of a virus strain that is incapable to cause disease. This process is generally difficult to accomplish and reversion to virulence is a constant risk. Molecular genetic methods currently make promise to alter the genes or modify the genetic makeup of an organism, so that it converts irrevocably attenuated. Intentional removal of genes with a code for proteins associated with virulence is an interesting procedure. For instance, in swine with pseudorabies virus (PRV), a herpesvirus of swine, gene-deleted vaccines were first used. In this case, the herpesvirus, thymidine kinase gene was removed from pseudorabies herpesvirus. Thymidine kinase is highly important for latency of herpesvirus. Viruses from which the thymidine kinase gene has been removed can infect neurons. However, these viruses are incapable to replicate. Also, they cannot cause any disease. Similar genetic modification can be employed to limit the capability of bacteria to grow in vivo.
For instance, an altered live vaccine that comprises streptomycin-dependent Pasteurella multocida and Mannheimia haemolytica is available. These mutants depend on the existence of streptomycin for growth. Absence of streptomycin ultimately results in death of bacteria, when these mutants used in the vaccine, but not before a defensive immune response is generated. In addition, it is feasible to modify the appearance of additional antigens so that the vaccine prompts an antibody response different from that produced by wild strains. This gives rise to a method to differentiate diseased animals from vaccinated animals (referred to as Differentiating Infected from Vaccinated Animals (DIVA) or Segregation Infected from Vaccinated Animals (SIVA)). Chances of reversion to virulence can also be reduced if two, dissimilar and specially disjointed genes are mutated or deleted. Considering all these factors, these new engineered vaccines can be considerably harmless than conventionally developed live vaccines.
These genetically engineered vaccines can also be used as marker vaccines. By deleting a vital gene, replication-incompetent vaccines can be developed. These are extremely harmless, as they cannot be discharged into the environment. Another benefit of live vaccines is that they can frequently be carried through the mucosal route, which is a natural path of infection, thereby inducing mucosal immunity with systemic immunity. By increasing mucosal immunity, development of a disease can be stopped at the beginning of infection itself. The global gene-deleted vaccines market is expanding at a significant pace, due to technological developments and emergence of new diseases. Increasing the genetic mutation by using different types of radiation and new diseases development are also augmenting the market. However, high cost of the technology and low success rate are major restraints for the gene-deleted vaccines market. Moreover, several issues surround the use of vaccines, for example, prevalence of a disease in a specific environment, government regulations, and safety. These factors are also restraining the market.
The global gene-deleted vaccines market can be segmented based on type of product, application, end-user, and geography. Based on type of product, the market has been classified into DNA vaccines, sub-unit vaccines, vector vaccines, Brucella abortus recombinant mutants, and others. Based on application, the market has been categorized into cattle, sheep, pigs, and others. Based on end-user, the market has been divided into veterinary hospitals, veterinary clinics, and animal care centers. Based on geography, the global gene-deleted vaccines market has been segregated into North America, Europe, Asia Pacific, and Rest of World.
Major players operating in the global gene-deleted vaccines market are Protein Sciences Corporation, Virbac SA, Merck Animal Health, Merial Ltd., Zoetis Inc., Boehringer Ingelheim GmbH, Ceva, Bayer AG, Biogenesis-Bago, Indian Immunologicals Ltd., and Heska Corporation.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.