Enzymes are molecules that perform catalytic functions in various biochemical reactions that occur in the body. Lysosomal Storage Disease (LSD) occurs due to deficiency of enzymes in the body and leads to malfunction of body organs. Enzyme replacement therapy is the process of replacement of enzymes with artificial enzymes in patients who are suffering from deficiency of enzymes. The therapy is carried out by administering intravenous infusion or by oral administration of enzyme containing preparation. Enzyme replacement therapies are intended to increase the concentration of enzymes but not for modifying underline root of the diseases. Enzyme replacement therapy is currently available for diseases such as Hunter syndrome, Fabry disease, digestive diseases, and Gaucher disease
The global enzyme replacement therapy market is expected to register high growth over the forecast period owing to factors such as wider availability of therapy, ease of guidelines for approval of enzyme replacement therapy, and advantages such as fewer side effects. Additionally, factors such as ease of access of enzyme replacement therapy and government support for treatment are expected to drive the growth of the market. However, reimbursement issues in various countries, and fewer side effects of therapy can significantly affect the growth of enzyme replacement therapy.
The enzyme replacement therapy market is segmented by enzyme type, indication, route of administration, and end user. On the basis of enzyme type, the market is segmented into imiglucerase, agalsidase beta, taliglucerase, velaglucerase alfa, laronidase, alglucosidase alfa, galsulfase, idursulfase, pancreatic enzymes, pegademase, and others. By indication, the market is segmented as Gaucher disease, Fabry disease, Scheie syndrome, Pompe disease, Hunter disease, combined immunodeficiency disease digestion (SCID), and others. By indication, the Gaucher disease segment is expected to expand at a high CAGR over the forecast period. Gaucher disease develops with the deficiency of an enzyme called glucocerebrosidase. This enzyme helps to break down fatty constituents in the body. When the enzyme levels are too low, fatty elements build up in parts of the body and cause damage.
On the basis of route of administration, the global enzyme replacement therapy market is segmented into two categories, oral route and parenteral route. By end user, the market is segmented as hospitals, homecare settings, and infusion centers. Among them, hospitals segment accounted for major shares in 2016, and infusion segment is expected to register high growth over the forecast period.
The global market for enzyme replacement therapy is also driven by some other factors such as financial help to patients by numerous non-profit organizations such as the National Gaucher CARE Foundation which makes easy accessibility of enzyme replacement therapy to patients.
Geographically, the global enzyme replacement therapy market is segmented as North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America is expected to register significant share in the global enzyme replacement therapy market owing to increasing acceptance of newer therapies as well as increasing prevalence of enzyme deficiency in the region. Moreover, favorable reimbursement policies, drug availability, and advanced healthcare infrastructure are expected to drive the market growth in North America and Europe. Asia Pacific is expected to register high CAGR during the forecast period owing to low cost of enzyme replacement therapies and rising awareness about enzyme replacement therapy in the region.
Key players in the global enzyme replacement therapy market are Shire plc. Genzyme Corporation, Pfizer Inc., Sigma-Tau Pharmaceuticals Inc., BioMarin Pharmaceutical, Inc., Merck KGaA, Essential Pharmaceuticals Limited, and AbbVie Inc .among others. Rising competition among small and large players in the global enzyme replacement therapy market is expected to drive the market during the forecast period.
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.
The study is a source of reliable data on:
- Market segments and sub-segments
- Market trends and dynamics
- Supply and demand
- Market size
- Current trends/opportunities/challenges
- Competitive landscape
- Technological breakthroughs
- Value chain and stakeholder analysis
The regional analysis covers:
- North America (U.S. and Canada)
- Latin America (Mexico, Brazil, Peru, Chile, and others)
- Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
- Eastern Europe (Poland and Russia)
- Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
- Middle East and Africa (GCC, Southern Africa, and North Africa)
The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.
A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.
Highlights of the report:
- A complete backdrop analysis, which includes an assessment of the parent market
- Important changes in market dynamics
- Market segmentation up to the second or third level
- Historical, current, and projected size of the market from the standpoint of both value and volume
- Reporting and evaluation of recent industry developments
- Market shares and strategies of key players
- Emerging niche segments and regional markets
- An objective assessment of the trajectory of the market
- Recommendations to companies for strengthening their foothold in the market
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.