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Enzymes are molecules that perform catalytic functions in various biochemical reactions that occur in the body. Lysosomal Storage Disease (LSD) occurs due to deficiency of enzymes in the body and leads to malfunction of body organs. Enzyme replacement therapy is the process of replacement of enzymes with artificial enzymes in patients who are suffering from deficiency of enzymes. The therapy is carried out by administering intravenous infusion or by oral administration of enzyme containing preparation. Enzyme replacement therapies are intended to increase the concentration of enzymes but not for modifying underline root of the diseases. Enzyme replacement therapy is currently available for diseases such as Hunter syndrome, Fabry disease, digestive diseases, and Gaucher disease

The global enzyme replacement therapy market is expected to register high growth over the forecast period owing to factors such as wider availability of therapy, ease of guidelines for approval of enzyme replacement therapy, and advantages such as fewer side effects. Additionally, factors such as ease of access of enzyme replacement therapy and government support for treatment are expected to drive the growth of the market. However, reimbursement issues in various countries, and fewer side effects of therapy can significantly affect the growth of enzyme replacement therapy.

The enzyme replacement therapy market is segmented by enzyme type, indication, route of administration, and end user. On the basis of enzyme type, the market is segmented into imiglucerase,  agalsidase beta, taliglucerase, velaglucerase alfa, laronidase, alglucosidase alfa, galsulfase, idursulfase, pancreatic enzymes, pegademase, and others. By indication, the market is segmented as Gaucher disease, Fabry disease, Scheie syndrome, Pompe disease, Hunter disease, combined immunodeficiency disease digestion (SCID), and others. By indication, the Gaucher disease segment is expected to expand at a high CAGR over the forecast period. Gaucher disease develops with the deficiency of an enzyme called glucocerebrosidase. This enzyme helps to break down fatty constituents in the body. When the enzyme levels are too low, fatty elements build up in parts of the body and cause damage.

On the basis of route of administration, the global enzyme replacement therapy market is segmented into two categories, oral route and parenteral route. By end user, the market is segmented as hospitals, homecare settings, and infusion centers. Among them, hospitals segment accounted for major shares in 2016, and infusion segment is expected to register high growth over the forecast period.

The global market for enzyme replacement therapy is also driven by some other factors such as financial help to patients by numerous non-profit organizations such as the National Gaucher CARE Foundation which makes easy accessibility of enzyme replacement therapy to patients.

Geographically, the global enzyme replacement therapy market is segmented as North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America is expected to register significant share in the global enzyme replacement therapy market owing to increasing acceptance of newer therapies as well as increasing prevalence of enzyme deficiency in the region. Moreover, favorable reimbursement policies, drug availability, and advanced healthcare infrastructure are expected to drive the market growth in North America and Europe. Asia Pacific is expected to register high CAGR during the forecast period owing to low cost of enzyme replacement therapies and rising awareness about enzyme replacement therapy in the region.

Key players in the global enzyme replacement therapy market are Shire plc. Genzyme Corporation, Pfizer Inc., Sigma-Tau Pharmaceuticals Inc., BioMarin Pharmaceutical, Inc., Merck KGaA, Essential Pharmaceuticals Limited, and AbbVie Inc .among others. Rising competition among small and large players in the global enzyme replacement therapy market is expected to drive the market during the forecast period.

This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.

Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:

  • Customer Experience Maps
  • Insights and Tools based on data-driven research
  • Actionable Results to meet all the business priorities
  • Strategic Frameworks to boost the growth journey

The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.

The following regional segments are covered comprehensively:

  • North America
  • Asia Pacific
  • Europe
  • Latin America
  • The Middle East and Africa

The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.

Below is a snapshot of these quadrants.

1. Customer Experience Map

The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

2. Insights and Tools

The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.

3. Actionable Results

The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.

4. Strategic Frameworks

The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Enzyme Replacement Therapy Market

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