Global Distraction Osteogenesis Devices Market: Introduction
Distraction Osteogenesis (DO) is defined as the formation of a new bone between the vascular surfaces of the osteotomized bone segments, separated gradually by distraction forces. It is a process employed in orthopedic and some other surgeries. Distraction Osteogenesis is carried out by surgical simulation of bone fractures via osteotomy of the deficient bone. Normal fracture healing occurs through a cascade of molecular and cellular events triggered in response to an injury. Formation of hematoma, followed by chondrogenesis and angiogenesis, eventually leads to formation of the hard callus by means of intramembranous and endochondral ossification. Distraction Osteogenesis proves advantageous over other conventional methods used for the management of bone defects, particularly bone grafting, wherein it provides simultaneous expansion of the functional soft tissue matrix, referred to as distraction histogenesis. During distraction Osteogenesis, however, the application of mechanical forces to the bone segments alters the repair process of the osteotomized bone segments, which is a characteristic feature of fracture healing, to a regenerative process. Evaluation of mechanotransduction mechanisms has demonstrated that tensile forces increase the expression of bone morphogenic proteins by osteoblasts and stimulate intramembranous bone formation.
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Global Distraction Osteogenesis Devices Market: Competitive Landscape
Johnson & Johnson Services, Inc.
Johnson & Johnson is engaged in R&D, manufacture, and sale of a broad range of health care products. The company operates through three business segments: pharmaceutical, medical devices, and consumer. The pharmaceutical segment focuses on five therapeutic areas: cardiovascular & metabolic diseases, immunology, neurosciences, oncology, and infectious diseases & vaccines. Under its medical devices segment, the company offers a wide range of products used in the fields such as surgery, cardiovascular, orthopedics, diabetes, and vision care. The consumer segment comprises baby care, oral care, women’s health care, wound care, and OTC (over-the-counter) pharmaceutical products.
Zimmer Biomet Holdings, Inc.
Zimmer Biomet is a leading global player that operates in the field of musculoskeletal health care. The company operates in more than 25 countries worldwide. It primarily engages in the design, manufacture, and marketing of orthopedic reconstructive products, biologic drugs, sports medicines, dental implants, surgical products, and spine, craniomaxillofacial and thoracic products. Its products are used to treat injuries and disorders of the bones, the joints, and the soft tissues. The company markets and sells its products to health care institutions, dental practitioners, and dental laboratories directly or distributes them through distributors and dealers. Zimmer Biomet caters to customers in over 100 countries across the globe.
Stryker is a global medical devices company offering products such as orthopedic implants for trauma and replacement surgeries; endoscopic and communication systems; emergency medical equipment and intensive care disposable products; and surgical equipment and surgical navigation systems. The company operates through three business segments: orthopedics, MedSurg, and Neurotechnology & spine. Through its orthopedics segment, the company offers joint replacement products under the brands such as Mako Partial Knee, Mako Total Knee, and Restoris MCK. As of December 2016, Stryker had registered over 2,184 U.S. patents and 3,454 international patents. The company provides medical devices to hospitals and other health care facilities in the U.S. It also offers products through subsidiaries and branches and other third-party dealers and distributors in more than 100 countries.
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Global Distraction Osteogenesis Devices Market: Dynamics
Rising prevalence of pediatric bone defects
The skeleton is continuously renewed through bone remodeling. Bone remodeling is a lifelong process wherein a mature bone is broken down by osteoclasts and a new bone is formed by osteoblasts. Bone formation on the outer periosteal surface increases the bone size, while resorption expands the marrow cavity and sculpts the outer surface of the bone. In children, linear growth occurs through strictly regulated, site-specific uncoupling of bone formation and resorption, which is termed as bone modeling.
Advancements in distractor devices such as miniaturized internal and external devices, easy placing, and easy handling
Lengthening of underdeveloped bones inclusive of the maxillofacial complex is attained by distraction Osteogenesis. Devices used for distraction Osteogenesis must have a minimum of two important features: they should be able to transfer distraction forces directly to the bone and, secondly, they should offer adequate rigidity for osseous consolidation to occur. The design of completely internalized custom-made appliances has opened new avenues in the field of oral & maxillofacial surgery. Indigenous internal devices are also economical and locally available.
Development of innovative solutions by manufacturers of distraction Osteogenesis devices
Recent studies have revealed that distraction Osteogenesis (DO) performed by using an automatic continuous distractor. Distraction force with high-resolution positioning control, along with a small-sized distractor placed in the oral cavity, can help in improving the result of the reconstruction operation, leading to a successful distraction Osteogenesis procedure in a short period of time.
The high cost of the entire treatment, and requirement for a second surgical procedure for removal of internal distractors are factors expected to hamper the global distraction Osteogenesis devices market during the forecast period.
Global Distraction Osteogenesis Devices Market: Segmentation
Based on device type, the global distraction Osteogenesis devices market can be segmented into:
- Mandibular Distraction Devices
- Palatal Distraction Devices
- Alveolar Distraction Devices
- Cranial Distraction Devices
- LeFort Distraction Devices
- Small Bone Distraction Devices
In terms of placement, the global distraction Osteogenesis devices market can be divided into:
- Internal Distractors
- External Distractors
The internal distractors segment can be sub-divided into:
- Tooth-borne Distractors
- Bone-borne Distractors
- Hybrid Distractors
The external distractors segment can be sub-classified into:
- Unidirectional Distractors
- Bidirectional Distractors
- Multiplanar Distractors
Based on age, the global distraction Osteogenesis devices market can be categorized into:
In terms of application, the global distraction Osteogenesis devices market can be segregated into:
Based on end-user, the global distraction Osteogenesis devices market can be segmented into:
- Orthopedic Clinics
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