Dendritic cells (DCs) are one of the major antigen-presenting cells found in lymphoid organs. Main function of the dendritic cells is antigen display and activation of T-cells. Antigen display presents the identity of pathogen to T-cells for their identification and elimination from the body. These cells have proficiency of capturing and processing tumor antigens, which activates expression of lymphocyte co-stimulatory molecules. Consequently, it results in secretion of cytokines to initiate immune response. In 1868, Paul Langerhans discovered dendritic cells. He thought they were a part of the nervous system cells due to their branched structure. Therefore, their identity was mistaken until the 1970s. In 1973, Zanvil Cohn and Ralph Steinman recognized them as a new type of white blood cells (WBC) with distinctive nature, features, concentration, and function in immunity.
Cancer is an enormously complex disease and researchers are still trying to understand the variety of factors responsible for its origin, transmission, metastasis, etc. According to report on cancer vaccines by the World Health Organization (WHO), in 2016, an anticipated 1.7 Mn new cancer cases were reported in the U.S. alone. Furthermore, the report mentioned that the annual incidence of cancer, worldwide, is projected to increase to 24 Mn by 2035. Presently, there is significant requirement for advanced and efficient treatments for cancer. Current standard approaches include radiation therapy, chemotherapy, and surgery. However, there are some risks and side effects associated with these methods. Different kinds of cancers have various sources of origin and have unique mechanisms which presents different complications in front of researchers to develop wide-ranging therapeutic treatments. Dendritic cells are adaptable in nature. Therefore, they can be modified depending on the cancer under examination, a dendritic cells vaccine can be formulated based on type of tumor accompanying antibodies. This vaccine can be expressed to target multiple cancers, which makes them effective for multiple objectives. Many of the clinical trials are investigating dendritic cell cancer vaccines which has the ability to help numerous patients. Currently, a steady supply of dendritic cells is necessary to develop novel cancer vaccines. Genetically modified dendritic cell cancer vaccines are grander tools for directing intractable cancers such as brain cancer therapy.
Many studies have shown dendritic cells have the potential ability in combinational therapies to restrict the growth of the cancer. The assured curable effect of therapeutics, which also includes these vaccines, has not been proven; however, they are anticipated to perform far better than its contenders in the same category. The rise in investments in research and development activities, together with positive results in clinical trials, are anticipated to drive the expansion of the market for global dendritic cell cancer vaccine. Others factors fuelling the expansion of this market include the ability of dendritic cells to target multiple cancer antigen capability, rise in geriatric population, and technological advancements. Computer technology is assisting oncologists to plan and run replications on hypothetical vaccines to check their consequences on cellular forms, before going to lab tests and utilizing costly resources.
However, the results of dendritic cell cancer vaccines remain mysterious in clinical trials. More than 70% of these vaccine candidates are currently in clinical trial phases of development. The global dendritic cells vaccines market has accomplished to capture the attention of many strategic investors and stakeholders due to a lucrative development in pipeline. More than USD 1.5 billion has already been invested in this area in the last five years. Oncologists believe that this market is likely to present considerable lucrative opportunities due to existing unmet demand for safe and effective cancer treatments with less side effects and the innate advantages of dendritic cells.
Currently, the three marketed cancer vaccines commercially available in different geographies are Provenge (U.S.), CreaVax-RCC (South Korea), and Tumor Antigen Presenting Cells i.e. TAPCells (Chile). Provenge, is the first marketed dendritic cell vaccine available in the market. They are targeted to treat prostate cancer, metastatic renal cell carcinoma, melanoma, and prostate cancer. In April 2010, the FDA approved the first cancer treatment vaccine. This vaccine, sipuleucel-T (Provenge), is approved for usage in some men with metastatic prostate cancer.
Key players operating in this market include 3M Company, Batavia Bioservices, Activartis, Dendreon, Merck KGaA, GlaxoSmithKline plc, Northwest Biotherapeutics, Tella Incorporation, Creagene, and ImmunoCellular Therapeutics.
This study by TMR is all-encompassing framework of the dynamics of the market. It mainly comprises critical assessment of consumers' or customers' journeys, current and emerging avenues, and strategic framework to enable CXOs take effective decisions.
Our key underpinning is the 4-Quadrant Framework EIRS that offers detailed visualization of four elements:
- Customer Experience Maps
- Insights and Tools based on data-driven research
- Actionable Results to meet all the business priorities
- Strategic Frameworks to boost the growth journey
The study strives to evaluate the current and future growth prospects, untapped avenues, factors shaping their revenue potential, and demand and consumption patterns in the global market by breaking it into region-wise assessment.
The following regional segments are covered comprehensively:
- North America
- Asia Pacific
- Latin America
- The Middle East and Africa
The EIRS quadrant framework in the report sums up our wide spectrum of data-driven research and advisory for CXOs to help them make better decisions for their businesses and stay as leaders.
Below is a snapshot of these quadrants.
1. Customer Experience Map
The study offers an in-depth assessment of various customers’ journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touchpoints. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.
2. Insights and Tools
The various insights in the study are based on elaborate cycles of primary and secondary research the analysts engage with during the course of research. The analysts and expert advisors at TMR adopt industry-wide, quantitative customer insights tools and market projection methodologies to arrive at results, which makes them reliable. The study not just offers estimations and projections, but also an uncluttered evaluation of these figures on the market dynamics. These insights merge data-driven research framework with qualitative consultations for business owners, CXOs, policy makers, and investors. The insights will also help their customers overcome their fears.
3. Actionable Results
The findings presented in this study by TMR are an indispensable guide for meeting all business priorities, including mission-critical ones. The results when implemented have shown tangible benefits to business stakeholders and industry entities to boost their performance. The results are tailored to fit the individual strategic framework. The study also illustrates some of the recent case studies on solving various problems by companies they faced in their consolidation journey.
4. Strategic Frameworks
The study equips businesses and anyone interested in the market to frame broad strategic frameworks. This has become more important than ever, given the current uncertainty due to COVID-19. The study deliberates on consultations to overcome various such past disruptions and foresees new ones to boost the preparedness. The frameworks help businesses plan their strategic alignments for recovery from such disruptive trends. Further, analysts at TMR helps you break down the complex scenario and bring resiliency in uncertain times.
The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:
1. What can be the best investment choices for venturing into new product and service lines?
2. What value propositions should businesses aim at while making new research and development funding?
3. Which regulations will be most helpful for stakeholders to boost their supply chain network?
4. Which regions might see the demand maturing in certain segments in near future?
5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?
6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?
7. Which government regulations might challenge the status of key regional markets?
8. How will the emerging political and economic scenario affect opportunities in key growth areas?
9. What are some of the value-grab opportunities in various segments?
10. What will be the barrier to entry for new players in the market?
Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.