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Antibody Fragments Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2016 - 2024

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Whole antibodies have grabbed a significant share of the global sales revenue as well as the volume of the biopharmaceuticals market. But with recent research and development efforts, it has come to light that the whole or full-length antibodies may always not be needed, or sometimes may not be desirable even for therapeutic use. Antibody fragments come in the picture at this point. For example, anti-tumor antibodies are larger in size and therefore can’t penetrate the tumor, thus affecting their therapeutic value in tumor suppression. Antibodies are also inappropriate for intracellular targeting sites because of their comparatively larger size. In this case, antibody fragments having specific sequences for the target site is used. Antibody fragments show enhanced penetration due to their smaller size. Antibody fragments can bind at highly specific sites and they can be manufactured or designed without the Fc region thus eliminating immunogenicity. Also, the antibody fragments have low manufacturing cost, high yield in production and extended therapeutic uses.

Antibody Fragments Market: Segmentation

On the basis of product type, the antibody fragments market can be segmented into,

  • F(ab) fragment
  • F(ab’)2 fragment

On the basis of disease indication, the antibody fragments market can be segmented into,

  • Cancer
  • Immunodeficiencies
  • Others

On the basis of region, the antibody fragments market can be segmented into,

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East Africa

Firstly, antibody fragments are segmented into F(ab) fragment and F(ab’)2. A papain digestion of an antibody will yield two F(ab) fragments. F(ab) fragment is a monovalent antibody structure devoid of the Fc region but has an antigen binding site. The F(ab) fragments are used to block the endogenous Ig's-immunoglobulins. However, F(ab’)2 fragments are obtained through the pepsin digestion of IgG antibody. This digestion will remove most of the Fc region but will keep some of the hinge region intact. This fragment has two antigen binding sites which are attached by disulfide bonds. The F(ab’)2 fragments are smaller in size and thus have better penetration. This antibody fragment also has a better antigen recognition feature, as these antibody fragments avoid unspecific binding. Both of these antibody fragments provide better results in the immunohistochemistry applications. Antibody fragments have a very vast range of therapeutic applications. The field of antibody fragments applications is just the revised or advanced version of monoclonal antibody therapeutic applications. Antibody fragments are very useful in medical diagnostics; specific antibody fragments are used for disease diagnosis. In some cases, multiple antibody fragments are used to spot antigens specific to cause a particular infectious disease. Antibody fragments are used to treat many immune deficiencies, central nervous system disorders, and cardiovascular diseases. Many antibody fragments are used to treat colorectal cancer and breast cancer.

Antibody Fragments Market: Market Dynamics

With increasing incidences of various types of cancers, infectious diseases and in turn immune deficiencies, there is going to be an increasing demand for antibody fragments. Also, an increase in geriatric population has been observed worldwide. Therefore, looking at the application prospects of antibody fragments, the market is likely to boom over the forecast period. Antibody fragments are also expected to be preferred compared to full-chain antibodies as the manufacturing and purification costs of antibody fragments are less. Strict ICD-10 guidelines may restrain the use of some antibody fragments for the treatment of a particular disease. However, new developments in the clinical development of antibody fragments for some of the deadliest diseases can give a massive opportunity for the antibody fragments market over the forecast period.

Antibody Fragments Market: Region-wise Outlook and Key Players

The occurrence of cancer and other immunodeficiencies are observed at a higher rate in North America compared to other regions. North America and Europe spend a significant amount of money on drugs and therapies related to cancer. It is estimated that North America is the largest market for antibody fragments, followed by Europe, trailed by Asia-Pacific, Latin America and the Middle East and Africa. The key players in the antibody fragments market are Novartis AG, F. Hoffmann-La Roche Ltd., Johnson & Johnson Services, Inc., Amgen Inc., Bristol-Myers Squibb Company, AbbVie Inc., Takeda Pharmaceutical Company Limited, Sanofi, Biogen Inc. and Eli Lilly and Co.

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The regional analysis covers:

  • North America (U.S. and Canada)
  • Latin America (Mexico, Brazil, Peru, Chile, and others)
  • Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
  • Eastern Europe (Poland and Russia)
  • Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
  • Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

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  • Important changes in market dynamics
  • Market segmentation up to the second or third level
  • Historical, current, and projected size of the market from the standpoint of both value and volume
  • Reporting and evaluation of recent industry developments
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  • Emerging niche segments and regional markets
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