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Alipogene Tiparvovec Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023

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Alipogene Tiparvovec is a gene therapy developed for the treatment of Lipoprotein Lipase Deficiency (LPLD), very rare inherited condition that is coupled with increased levels of fat in the blood which can cause severe pancreatitis.  It is a first therapeutic cure available for LPLD patients. Earlier, patients were predominantly treated with severe dietary fat restriction and the use of medium-chain triglycerides with persisting risk of disease progression or pancreatitis. Alipogene Tiparvovec is marketed under the trade name Glybera. Alipogene tiparvovec was developed by Amsterdam Molecular Therapeutics (AMT), which was acquired by uniQure in April 2012. In October 2012, uniQure received marketing authorization approval for Glybera from the European Commission (EC) for treating patients with LPLD who have chronic and acute pancreatitis attacks. Alipogene tiparvovec is the first gene therapy to be licensed in Europe and is administered intramuscularly into the leg muscle. Glybera is a significantly expensive treatment costing approximately USD 1.6 million.

 

Lipoprotein lipase deficiency prevalence is estimated at one to two per million. It is the most ordinary cause of hyperchylomicronaemia, a situation in which triglycerides are not offloaded from chylomicrons because of dysfunctional LPL, causing continuous and extremely high levels of plasma chylomicrons and severe hypertriglyceridaemia. Alipogene Tiparvovec has been tested in three interventional clinical studies conducted in Netherlands and in Canada, in which a total of 27 LPLD patients participated. In all three clinical trials, Glybera was well tolerated, with no relevant safety issues observed. Data from these clinical trials show that a single dose administration of Glybera resulted in a long-term biological activity of the LPL protein and reduction in the episodes of acute pancreatitis. Interventional studies have always shown that alipogene tiparvovec is well tolerated without dose-limiting toxicity. 

 

The most common side effect reported with Glybera was pain in the legs, tiredness, headache, and hyperthermia (high body temperature). Glybera must not be used in patients with increased risk of bleeding and muscle disease, immunodeficiency (weakened immunity), along with anti-coagulant medicines, which can increase bleeding. Patients must also not use oral contraceptives along with Glybera.

 

There are certain government organizations which provide funding for research and development of alipogene tiparvovec which acts as a driving factor for global gene therapy market. The UCLA Center for Pancreatic Diseases (CPD) is one of them. The clinical arm of the UCLA Center for Pancreatic Diseases applies a multidisciplinary approach to the evaluation and treatment of patients with pancreatic diseases. However, the high cost associated with research activities and sunk costs involved in research & development activities are restraining the immune checkpoint inhibitors market.

 

Geographically, the global alipogene tiparvovec market is segmented into North America, Europe, Asia-Pacific (APAC) and Rest of the World. The European Medicines Agency (EMA) has approved Glybera, for sale across Europe. Glybera is the first gene therapy to be approved in Europe and North America and offers an effective therapeutic treatment for people with LPLD.  LPLD is more prevalent in Canada and South Africa according to a published study by Elsevier Ireland Ltd. in 2010. Thus major market for alipogene tiparvovec lies in the Canada and African region where the prevalence of LPLD is high. 

 

The marketing authorization holder of alipogene tiparvovec drug is UniQure biopharma B.V. Other major market players involved in the research and development of alipogene tiparvovec drug are, International Antiviral Therapy Evaluation Center, the Clinical Trial Company Limited and ICON.

 

This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. Geographies analyzed under this research report include 

  • North America 
  • Asia Pacific 
  • Europe
  • Rest of the World  

 

This report provides comprehensive analysis of 

 

  • Market growth drivers 
  • Factors limiting market growth
  • Current market trends 
  • Market structure
  • Market projections for upcoming years 

 

This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porter’s five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis. 

 

Reasons for Buying this Report

  • This report provides pin-point analysis for changing competitive dynamics
  • It provides a forward looking perspective on different factors driving or restraining market growth 
  • It provides a six-year forecast assessed on the basis of how the market is predicted to grow 
  • It helps in understanding the key product segments and their future
  • It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors
  • It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments 
  • It provides distinctive graphics and exemplified SWOT analysis of major market segments 


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